NFIB Vermont discusses importance of shopping local on Small Business Saturday, Nov 30

Vermont Business Magazine NFIB State Director Shawn Shouldice is urging Vermonters to support local shops and restaurants this weekend on Small Business Saturday, Nov. 30th. “In addition to creating good-paying jobs and strengthening the local economy, small businesses shape our communities by volunteering their time and financially supporting charitable organizations,” said Shouldice. “A recent NFIB report highlights how small business owners and their employees benefit their communities, beyond operating their businesses.” 
“Every dollar people spend at a local small business helps sustain and strengthen our hometowns,” continued Shouldice. It’s estimated that 67 cents of every dollar spent at a small business stays in the community. As we kick off the holiday season, I encourage all Vermonters to shop small, especially on Small Business Saturday, and thank a small business owner for how they enrich your community.”
Background:
Sandwiched between Black Friday and Cyber Monday, Small Business Saturday began in 2010 as a way to help local stores and restaurants recover from the Great Recession. It has quickly transformed into a Thanksgiving weekend tradition, becoming one of the busiest sales seasons for small business owners nationwide.
CLICK HERE to view the 2024 Small Businesses’ Contribution to the Community report.
About NFIB:
For more than 80 years, the National Federation of Independent Business (NFIB) has been the voice of small business, advocating on behalf of America’s small and independent business owners, both in Washington, D.C., and in all 50 state capitals. NFIB is nonprofit, nonpartisan, and member driven. Since our founding in 1943, NFIB has been exclusively dedicated to small and independent businesses and remains so today. For more information, please visit www.NFIB.com.
Source: MONTPELIER, VT (Nov. 27, 2024) – NFIB
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‘Securing someone of Sean’s calibre, with his extensive experience and passion for customer excellence, is a significant win for our business’

Watch more of our videos on ShotsTV.com and on Freeview 262 or Freely 565Visit Shots! nowSelling over 5,000 new and used cars annually, Shelbourne Motors employs more than 160 highly skilled staff across its award-winning dealerships in Portadown and NewryNorthern Ireland vehicle retailer Shelbourne Motors has strengthened its senior management team with the appointment of Sean McCormick as aftersales manager at its award-winning Kia, Renault, and Dacia, franchises in Newry.With 13 years of extensive experience in the motor industry, including 12 years in managerial roles, Sean is a proven leader renowned for delivering exceptional customer service and operational excellence.Sean’s career began with the Renault and Dacia franchises, where he quickly progressed from CRC advisor to service manager, showcasing his ability to lead high-performing teams and exceed customer expectations.He then moved to the premium vehicle sector as aftersales manager for Jaguar Land Rover, where he demonstrated his expertise in optimising operations and enhancing the customer experience.Read More£15m investment in refurbished Stewartstown Road store and new anchor store at C…In his new role, Sean will bring a wealth of expertise and innovative leadership to Shelbourne Motors’ Newry site, driving forward a best-in-class aftersales operation across its Kia, Renault, and Dacia franchises, while also delivering exceptional servicing solutions for all makes and models.His focus on operational efficiency, team development, and a commitment to customer satisfaction will ensure that Shelbourne Motors continues to build on its reputation for excellence and drive forward its ambitious growth strategy.Shelbourne Motors has strengthened its senior management team with the appointment of Sean McCormick as aftersales manager at its award-winning Kia, Renault, and Dacia, franchises in Newry. Pictured with Sean McCormick is Alan Thompson, chief operating officer at Shelbourne MotorsAlan Thompson, chief operating officer at Shelbourne Motors, said: “We’re delighted to welcome Sean to the Shelbourne Motors team as aftersales manager. Securing someone of Sean’s calibre, with his extensive experience and passion for customer excellence, is a significant win for our business.“Shelbourne Motors has a proud reputation for delivering exceptional aftersales service, and Sean’s leadership and expertise will play a key role in ensuring we continue to set the standard for best-in-class customer care.”Founded by the Ward Family in 1973, Shelbourne Motors is one of Northern Ireland’s leading vehicle retailers, renowned for its commitment to excellence. Selling over 5,000 new and used cars annually, the business employs more than 160 highly skilled staff across its award-winning dealerships in Portadown and Newry.Shelbourne Motors, winner of Dealer of the Year at the 2024 Northern Ireland Motor Industry Awards, represents a portfolio of top-tier franchises, including Toyota, Renault, Nissan, Kia, Dacia, and MAXUS.The company also offers a comprehensive range of services through its own premium used car brand, Autoselect, its industry-leading contract hire and leasing division, fleet4u, and its cutting-edge vehicle rental brand, SVRgo.

These 22 Children’s Movies Are So Beyond Devastating, They’re Borderline Unwatchable As Adults

“E.T. is terrifying and sad. Saw it once when I was a kid, and will never watch it again. Very upsetting movie.”—rhonda20″I think it’s worth watching again (or at least finishing it for those who didn’t). it does end on a happy note. And I do still cry every time when E.T. is sick, so I get it, and I know it ends well, but I still cry, LOL, but that shows how good of a movie it is to me, that it still has that effect on me. JMO, of course, but I’ve seen it many, many times and still like it. it ends happily, so I guess it’s worth the crying, LOL.I was 12 the first time I saw it, when it came out.”—pikakats”I still remember being terrified during that scene where E.T. is sick, and the government scientists — or whatever they’re supposed to be — are experimenting on him and Elliott. I was probably a preschooler when I saw it, and I’ve never seen that movie all the way through again!”—leslies22

School of Engineering to host defense technology seminar

MACON —Mercer University’s School of Engineering will host a Defense Technology Seminar, featuring a presentation by retired U.S. Air Force pilot Lt. Col. Glenn Baugher, on Wednesday, Dec. 6, at 8 p.m. in the Peyton Anderson Auditorium in the Science and Engineering building on the Macon campus.

Lt. Col. Baugher is currently teaching future aviators how to fly at ground school courses through Eastern Mennonite University in Lancaster, Pennsylvania, and he volunteers with the U.S. Air Force Civil Air Patrol. He graduated from the U.S. Air Force Academy with a B.S. in electrical engineering and computer science.

He has more than 3,400 total flying hours, including 1,300 hours flying the T-38 aircraft and more than 900 hours in the A-10 and the F-117 Nighthawk Stealth Fighter aircraft. While on active duty, he served as program manager at the U.S. Air Force Pentagon. After he retired, Lt. Col. Baugher spent 20 years as a defense contractor in the Washington D.C., area.

The event is free and open to the public and will be followed by an awards ceremony for Mercer’s software engineering students and a showing of the 1955 Jimmy Stewart film “Strategic Air Command.”

School of Engineering to host defense technology seminar

MACON —Mercer University’s School of Engineering will host a Defense Technology Seminar, featuring a presentation by retired U.S. Air Force pilot Lt. Col. Glenn Baugher, on Wednesday, Dec. 6, at 8 p.m. in the Peyton Anderson Auditorium in the Science and Engineering building on the Macon campus.

Lt. Col. Baugher is currently teaching future aviators how to fly at ground school courses through Eastern Mennonite University in Lancaster, Pennsylvania, and he volunteers with the U.S. Air Force Civil Air Patrol. He graduated from the U.S. Air Force Academy with a B.S. in electrical engineering and computer science.

He has more than 3,400 total flying hours, including 1,300 hours flying the T-38 aircraft and more than 900 hours in the A-10 and the F-117 Nighthawk Stealth Fighter aircraft. While on active duty, he served as program manager at the U.S. Air Force Pentagon. After he retired, Lt. Col. Baugher spent 20 years as a defense contractor in the Washington D.C., area.

The event is free and open to the public and will be followed by an awards ceremony for Mercer’s software engineering students and a showing of the 1955 Jimmy Stewart film “Strategic Air Command.”

Scientists Uncover Hidden RNA Structure That Triggers Parkinson’s Disease

Researchers discovered that G4 RNA structures drive harmful protein aggregations linked to neurodegeneration, suggesting new treatment possibilities. Credit: SciTechDaily.com
Researchers have identified that G-quadruplexes promote harmful protein aggregation in neurodegenerative diseases. Blocking G4s with 5-ALA stopped Parkinson’s-like symptoms in mice, suggesting a promising path for early disease intervention.
Researchers at Kumamoto University have discovered a groundbreaking mechanism behind the formation of harmful protein aggregates that contribute to neurodegenerative diseases like Parkinson’s Disease.
The team, led by Professor Norifumi Shioda and Associate Professor Yasushi Yabuki, identified for the first time that unique RNA structures called G-quadruplexes (G4s) play a central role in promoting the aggregation of α-synuclein, a protein associated with neurodegeneration. By demonstrating that inhibiting G4 assembly could potentially prevent the onset of synucleinopathies, this discovery positions G4 as a promising target for early intervention in these diseases.
In a healthy state, α-synuclein typically regulates neuronal function. However, in neurodegenerative diseases, it aggregates together, leading to cell damage and motor symptoms.
The trigger for neurodegeneration is the assembly of G4 structures driven by increased intracellular calcium ions (Ca2+) due to cellular stress. α-Synuclein binds directly to G4, shifting into an aggregate-prone structure that employs G4 as a scaffold to form harmful clusters. Therefore, inhibiting G4 assembly can prevent α-synuclein aggregation, helping to protect against neuronal function loss. Credit: Norifumi Shioda, Yasushi Yabuki, Kumamoto University
The researchers identified that G4s, four-stranded RNA structures that form in response to cellular stress, function as a “scaffold” that facilitates α-synuclein aggregation. Elevated calcium levels, often seen under stress, trigger G4 assembly, which then attracts α-synuclein, converting it into a harmful, aggregate-prone state.
A Novel Intervention: 5-ALA Treatment
The team went a step further, demonstrating a new approach to prevent this process. They administered 5-aminolevulinic acid (5-ALA), a compound that blocks G4 formation, to model mice exhibiting Parkinson’s-like symptoms. Impressively, 5-ALA treatment not only prevented α-synuclein aggregation but also halted the progression of motor symptoms, a promising sign for potential therapies targeting early-stage neurodegeneration.
This breakthrough could significantly advance treatments aimed at neurodegenerative diseases by focusing on G4 regulation. Since G4s are also implicated in other diseases such as Alzheimer’s Disease, this discovery may broaden the impact of such treatments beyond Parkinson’s Disease. These findings also shed new light on preemptive strategies to combat neurodegeneration and improve the quality of life for aging populations.
Reference: “RNA G-quadruplexes form scaffolds that promote neuropathological α-synuclein aggregation” by Kazuya Matsuo, Sefan Asamitsu, Kohei Maeda, Hiroyoshi Suzuki, Kosuke Kawakubo, Ginji Komiya, Kenta Kudo, Yusuke Sakai, Karin Hori, Susumu Ikenoshita, Shingo Usuki, Shiori Funahashi, Hideki Oizumi, Atsushi Takeda, Yasushi Kawata, Tomohiro Mizobata, Norifumi Shioda and Yasushi Yabuki, 18 October 2024, Cell.DOI: 10.1016/j.cell.2024.09.037
Funding: Japan Agency for Medical Research and Development, Japan Society for the Promotion of Science, Fusion Oriented REsearch for disruptive Science and Technology, MEXT Promotion of Development of a Joint Usage/Research System Project: Coalition of Universities for Research Excellence Program (CURE), Pharmacological Research Foundation, Tokyo, Kowa Life Science Foundation, Narishige Neuroscience Research Foundation, Mochida Memorial Foundation for Medical and Pharmaceutical Research, Astellas Foundation for Research on Metabolic Disorders, the Foundation of SBI Pharmaceuticals Co., Ltd., Takeda Science Foundation

Thanksgiving travel snarled by coast-to-coast storm bringing rain and snow

With Thanksgiving holiday travel well underway, many have reached their destinations — but for everyone else, a storm tracking from the Rockies to the Midwest and Northeast into tomorrow will bring rain and snow, likely impacting flights and packed roads.Just shy of 3 million people are expected to be screened by TSA today, and a record 71.7 million are expected travel by car over Thanksgiving — over 1 million more than last year. The storm, already dropping snow over the Rockies Wednesday morning, is forecast to race east throughout today to the Midwest and Northeast through Thanksgiving.It’ll bring rain that will intensify in the evening from St. Louis to Indianapolis and into Pittsburgh.Airports in Denver, Kansas City, St. Louis are expected to see impacts of that weather today, NBC News’s Al Roker said on the “TODAY” show Wednesday, with slowdowns possible in Nashville, Dallas, Houston and Austin. As of Wednesday morning, air travel was running relatively smoothly with nearly 500 delayed and 20 cancelled flights, according to FlightAware.A ground delay at Newark Liberty International Airport in New Jersey, due to a shortage of air traffic controllers, lifted at 1 a.m. Wednesday. For road travelers, I-80, I-64, I-75 will be impacted by rain Wednesday, and I-25 and I-70 with snow in the Rockies. Thanksgiving Day will bring a mess of rain for the I-95 corridor from Florida to Maine, and accumulating snow for the interior Northeast and northern New England. Points north of the Hudson Valley in upstate New York and interior New England can expect 1 to 3 inches of wet snow, with localized totals of over 6 inches at highest mountain peaks.The iconic Macy’s Thanksgiving Day Parade will go on rain or shine, as the Big Apple is forecast to see soaking rain with temperatures in the 40s. Winds are forecast to be less than 10 mph, which will allow balloons to fly. The parade’s beloved balloons cannot fly if maximum sustained winds hit 23 mph or greater or if gusts exceed 34 mph.East Coast cities including Baltimore, Washington DC, New York, Hartford, and Boston can expect a cold rain, with rainfall totals between .50 to 1 inch. Road travel will be slick as far south as Virginia and Maryland, including through the I-95 corridor into Maine. By the overnight hours into Friday morning, travel will settle to mostly normal conditions as the system pushes out of the New England area. However, a lake effect snow event starts up around the Great Lakes and will continue through Sunday.Airport hubs to watch Thursday include Atlanta, Charlotte, Washington D.C., Philadelphia, NYC, Boston, Pittsburgh, and Buffalo.People enter LaGuardia Airport in New York City on one of the busiest travel days of the year on Tuesday.Spencer Platt / Getty ImagesOn Sunday — typically the busiest travel day of Thanksgiving week as people return home from holiday trips — the cold will continue across swaths of the country, as well as lake effect snow around the Great Lakes and Northeast. A total of 3 million people are predicted to pass through TSA on Sunday, nearing the record of 3.01 million that was set the Sunday following the Fourth of July holiday this year. Chicago and Detroit may see some problems at their airports on Sunday, but the East and West Coast look favorable for road and air travel.All the while much of the northern Plains and upper Midwest will see bitter cold to close out the week, with temperatures forecast to be 10 to 20 degrees below average starting on Thanksgiving Day. From Thursday to Sunday, Chicago will see highs in the 30s and 20s and lows in the teens, New York will see highs in the 40s and lows dip to around 28F, and D.C. will see highs in the 50s and 40s and lows in the 30s and high 20s. Minneapolis will see lows into the single digits over the weekend. As travelers take the skies to join loved ones, authorities are warning people who leave their cars in airport parking lots to take caution due to vehicle thefts.Over 300 cars were stolen from the nation’s busiest airport, Hartsfield-Jackson Atlanta International Airport, this year — nearly three times as many as last year, Atlanta Police said.“Suspects can program key fobs to vehicles and that has gotten us here where we are now,” Maj. Kelley Collier, the Atlanta Airport precinct commander said. This year, police are adding cameras, motorcycle patrols, and new fencing to curb crime across its 30,000 parking spaces. More than 50 vehicles were also stolen from Dallas Fort Worth International Airport this year, as police said a car theft ring targeting airports across multiple states was responsible. DFW Airport Police arrested the alleged ringleader last month.A woman named Katy told NBC News she and her husband had went on a work trip and returned to Columbus International Airport to find their car was gone.“In complete disbelief that we had parked attached to an airport and came out and our car was gone. We just assumed it was more safe and secure in that type of an environment,” she said. Police later found it abandoned and completely stripped. “I’m hoping that the airports will beef up their security so that we can travel and come back and have your car there,” she added.