Sutter Health names first CMO of medical education and science

Sacramento, Calif.-based Sutter Health has named Lindsay Mazotti, MD, as its first chief medical officer of medical education and science.In her new role, Dr. Mazotti will be the senior academic physician executive who oversees development and growth for the organization’s graduate medical education and research, according to an April 16 Sutter Health news release shared with Becker’s.
Dr. Mazotti will report to Conrad Vial, MD, president of Sutter Health Network at Sutter Health, and serve as the clinical dyad partner to Sutter Health’s chief academic affairs officer Leon Clark. 
Dr. Mazotti and Mr. Clark will oversee expansion of accredited residency and fellowship programs; create and grow clinical and translational research programs for Sutter; partner with federal, academic, industry and community organizations; and build diversity, equity and inclusion throughout academic functions at Sutter and head faculty development.
Prior to her new role, Dr. Mazotti served in dual educational leadership roles at Pasadena, Calif.-based Kaiser Permanente Bernard J. Tyson School of Medicine and Oakland, Calif.-based Kaiser Permanente East Bay Medical Center. 

CNIC scientists identify therapeutic targets for the prevention of heart injury linked to cancer treatment

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified the mechanisms through which anthracyclines, a widely used class of anticancer drugs, damage the hearts of patients receiving this treatment. The study, published in the journal JACC: CardioOncology, also identifies possible treatments for this complication, which affects an estimated one third of cancer survivors.  
Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified the mechanisms through which anthracyclines, a widely used class of anticancer drugs, damage the hearts of patients receiving this treatment. The study, published in the journal JACC: CardioOncology, also identifies possible treatments for this complication, which affects an estimated one third of cancer survivors.  
More than 4 million people in Europe are diagnosed with cancer every year. Fortunately, survival rates have increased significantly thanks to improved treatments and advances in diagnosis.Anthracyclines, used in combination with other drugs, have been established for many decades as drugs of choice in the first-line treatment of many types of cancer. An estimated 3 million patients are treated with anthracyclines in Europe every year. Unfortunately, these drugs are cardiotoxic, and a third of patients treated with anthracyclines develop some degree of cardiac injury. In many patients, the toxic effects do not have serious long-term consequences; however, in more than 5% of cancer survivors, the irreversible cardiac injury caused by anthracycline therapy leads to chronic heart failure, severely limiting quality of life
Although anthracycline-induced cardiotoxicity has been known about for many years, no specific cotreatments have been developed to protect the heart against injury during cancer therapy. This is in part due to the incomplete understanding of the molecular mechanisms through which anthracyclines damage the heart.
Now, researchers in Translational Laboratory for Cardiovascular Imaging and Therapy at the CNIC, led by Dr. Borja Ibáñez, have identified the underlying mechanisms through a detailed analysis of the progressive effects of anthracycline therapy on cardiac metabolism in an experimental animal model, with particular emphasis on mitochondria.
 “The heart beats without interruption throughout life and has one of the most intense energy requirements of any organ in the body. This unceasing activity requires a continuous supply of energy, and any failure in the energy production chain has major consequences,” said Dr. Ibáñez, who is CNIC Scientific Director, a cardiologist at Fundación Jiménez Díaz university hospital, and a group leader in the Spanish cardiovascular research network (CIBERCV). “Mitochondria are power plants within cells that generate energy continuously by consuming fuel substrates, mostly fatty acids and glucose. In the study, we saw that anthracyclines alter cardiac metabolism, causing a change in the supply of these fuels and an irreversible dysfunction in energy production by mitochondria.”“We observed that the metabolic changes in the heart occur very early after the initiation of anthracycline treatment, long before any loss of contractile function,” explained first author Anabel Díaz-Guerra, a pre-doctoral fellow at the CNIC supported by the Asociación Española Contra el Cáncer. “We found that, as a consequence of these metabolic alterations, the heart begins to atrophy (its cells lose volume) in one of the first signs of irreversible damage.”
These findings are especially important because the changes appear long before cardiac alterations can be detected by conventional means, stressed Dr. Laura Cádiz, a member of the CNIC research team. “By minutely studying each stage of the process, we were able to identify the molecular alterations underlying the deterioration in cardiac metabolism. And this in turn allowed us to identify steps in the process that could be prevented by very early interventions.”
One possible intervention involves a specific dietary adjustment, and the team is currently investigating the ability of a protein-enriched diet to prevent muscle atrophy, including cardiac muscle atrophy, induced by anthracycline chemotherapy.
This project is in part a continuation of Dr. Ibáñez’s earlier work on nutritional approaches to preventing cardiotoxicity in cancer treatments, for which he was awarded the Fundación Jesús Serra clinical research prize. “Reflecting our translational research vision, our ultimate goal is to test new therapeutic targets in patients at risk of anthracycline-induced cytotoxicity. Right now, we are studying the effect of a dietary intervention in the same experimental model, and if the encouraging preliminary results are confirmed this will be pursued in a clinical trial,” said Dr. Ibañez.
The CNIC is committed to finding solutions to unresolved clinical needs and, within its Myocardial Homeostasis & Cardiac Injury program, has set up a research line dedicated to chemotherapy-associated cardiotoxicity, with a particular focus on anthracyclines. The goal is to develop treatments that maintain the efficacy of the anticancer treatment while minimizing negative impacts on cardiovascular health.
Dr. Ibañez’s research group also coordinates projects financed by the European Commission (ERC-Consolidator “MATRIX” and Horizon2020-HEALTH “RESILIENCE”), both aimed at reducing the prevalence of heart failure among cancer survivors. Imbued with a translational and multidisciplinary vision, these projects are being conducted through partnerships between the CNIC, Fundación Jiménez Díaz University Hospital, and the CIBERCV.
The current study received support from the European Commission (ERC-CoG 819775 and H2020-HEALTH 945118), the Spanish Ministry of Science, Innovation, and Universities (PID2022-140176OB-I00), and the Community of Madrid regional government through the Madrid Network for Nanomedicine in Molecular Imaging (P2022/BMD-7403 RENIM-CM).
About the CNIC
The CNIC is an affiliate center of the Carlos III Health Institute (ISCIII), an executive agency of the Spanish Ministry of Science, Innovation, and Universities. Directed by Dr. Valentín Fuster, the CNIC is dedicated to cardiovascular research and the translation of the knowledge gained into real benefits for patients. The CNIC has been recognized by the Spanish government as a Severo Ochoa center of excellence (award CEX2020-001041-S, funded by MICIN/AEI/10.13039/501100011033). The center is financed through a pioneering public-private partnership between the government (through the ISCIII) and the Pro-CNIC Foundation, which brings together 12 of the most important Spanish private companies.

Journal JACC CardioOncology Method of Research Experimental study Subject of Research People Article Title Evolution Of Myocardial Metabolism and Mitochondrial Quality Control During Anthracycline-Induced Cardiotoxicity: Novel Therapeutic Targets Identification Article Publication Date 16-Apr-2024

Computer scientist William Wang receives prestigious early career technical achievement award

(Santa Barbara, Calif.) — As artificial intelligence continues to boom, scaling algorithms to ever-increasing data sets also becomes a bigger hurdle. Such is the case in the domain of natural language processing (NLP), or, the effort to get machines to understand and communicate with human language (think: ChatGPT, search engines and other text-based modalities).
(Santa Barbara, Calif.) — As artificial intelligence continues to boom, scaling algorithms to ever-increasing data sets also becomes a bigger hurdle. Such is the case in the domain of natural language processing (NLP), or, the effort to get machines to understand and communicate with human language (think: ChatGPT, search engines and other text-based modalities).“A key challenge in this domain is the tradeoff between scalability and accuracy,” said UC Santa Barbara computer scientist William Wang, who specializes in NLP. “While faster algorithms often compromise accuracy, more accurate models tend to be slower. Achieving a balance between these two aspects is critical yet challenging.” Thanks to the diversity of human expression, AI language models can often trip over things like ambiguity, slang, sarcasm, irony, translations, multiple meanings and other vagaries of human speech, or the models can take too long in interpreting them to be useful.
Wang’s considerable work to develop scalable algorithms that are both swift and accurate couldn’t be more necessary. And for his efforts, he has been awarded the Institute of Electrical and Electronics Engineers (IEEE) Signal Processing Society’s (SPS) Pierre-Simon Laplace Early Career Technical Achievement Award. He recently received this award in April, in Seoul, Korea.
“I’m extremely honored for this major award from IEEE SPS, and I have been a big fan of Laplace’s work,” said Wang, who was cited “for contributions to the development of scalable algorithms in natural language processing.” The award “honors an individual who, over a period of years in his/her early career, has made significant contributions to theory and/or practice in technical areas within the scope of the Society.”
Addressing problems in structured learning — in which the AI model is expected to predict multiple outputs per data input — has been a focal point of Wang’s research. “This is notably difficult due to the vast search space,” he said. The Wang Lab’s recent work with logic programs streamlines the process by utilizing in-context learning by large language models to enhance accuracy and reduce hallucinations (nonsensical outputs), without the need for further optimization algorithms. Another recent achievement involves an algorithm that accelerates the speed at which text-to-image models can predict output from novel data.Laplace’s work — the 18th-19th century French scholar is known for, among other things, advances within the realm of statistics and probability — plays a big role in Wang’s career, from creating constraints on data sets, to improving accuracy, to inferring variables based on observed data. The Wang research group’s recent paper at the NeurIPS 2023 conference uses Laplace’s signature Bayesian interpretation of probability to elucidate the emergent behavior of large language models.
Wang, who holds the campus’s Duncan and Suzanne Mellichamp Chair in Artificial Intelligence and Designs, and is also the director of UCSB Center for Responsible Machine Learning and of the UCSB NLP group, looks forward to further improving how AI can learn and interpret language.
“Scalable algorithms are vital for the advancement of AI,” he said. “Current state-of-the-art models in AI, including large language models and generative algorithms, are not optimally efficient in training and inference. Future AI development hinges on innovations in algorithms and architecture, promising more efficient training and inference processes for upcoming AI models.”

CISCO’s Free Data Science & Data Analytic Courses, 2024

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In 2024, CISCO will offer complimentary Data Science courses to learners worldwide
In a highly dynamic region of technology, data science has acquired the necessary importance since it promotes innovation and improves performance among sectors. Pandemic-induced mass unemployment has triggered a growing need for skilled professionals in tech, hence, in 2024, Cisco as well as some other tech giants launched free data science courses aiming at democratizing education and helping workers to improve their career prospects in tech.
Cisco’s engagement in training IT specialists can be beneficial to IT education in Russia:
Cisco as the global pioneer in networking systems and cyber-security solutions is prominent worldwide facilitating various training and certification programs. Cisco now launches free data science courses, which is just an incoming example of the tradition of supporting skills development in the IT world.
The data science course offerings, 2024 course
Cisco’s free data science courses for the year 2024 are for any learner, be they a total newbie or those who are looking to polish existing skills. The courses covered primary areas like data wrangling, data manipulation, data visualization, big data technologies, machine learning, and statistics knowledge, and comprehensively prepared the students for the data science career.
Cisco also provides a comprehensive set of Data Analytics courses for everyone. Let us have a look.
Data Analytics FREE Certification courses
IoT Fundamentals: Big Data & Analytics
Architectures and processes of the past are making way for more modern, real-time applications thanks to IoT (Internet of Things) systems and the data they collect. Dynamic data platforms are being built, and our ability to extract data using the latest analytics techniques is growing. So why not gain an edge and increase your employability by learning new skills? Skills such as collecting, storing, and visualizing data obtained from IoT sensors are in high demand. Be one of the few who know how to use data analytics to gain amazing insights from the intelligence produced.
You’ll Study These Core Skills:
Create code that reads data from sensors and stores it in an SQL database by using Python.Visualize, clean, manipulate, and integrate data sets.Learn fundamental principles of Big Data platforms like Hadoop.Use storytelling to present insights gained from extracted data.
 This data analytics essentials course teaches you the fundamental tools of a data analyst. By the end of the course, you will have an analytics portfolio complete with an analysis of the popular movies dataset, showcasing your skills in Excel, SQL, and Tableau.
Data Analytics Essentials
The Future of Education Information:
In essence, the thirst for data science skills isn’t going to end soon, hence, making free, high-quality education one of the most crucial supplies required for building our workforce. These data mining courses that Cisco offers in 2024 are a sign of the possibilities of the future that could be seen by anyone with the interest and determination to follow a career in the field that is constantly developing.
Cisco’s data science curricula tuition-free in 2024 point to a big leap in education level for the tech sector. Through giving reachable, flexible, and useful learning opportunities, Cisco is not only helping single people develop professionally but also making up the future of our technological world.
Data Analytics Essentials:
This data analytics essentials course provides you with the fundamental tools of a data analyst. In this, you will see how to transform, organize, and visualize data with spreadsheet tools like Excel learn how to query data from a relational database using SQL, and how to improve your data presentations using powerful business intelligence tools such as Tableau. Upon completion of the course, you will possess an analytics portfolio containing an analysis of the widely-used movie dataset, demonstrating proficiency in Excel, SQL, and Tableau.

Can Data Science Jobs Stay in Demand for The Next 5 Years?

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Explore these factors that keep data science jobs in demand
Data science has been among the fields of study which are blossomed very fast in recent years and the major contributing factors, to this include the digitization of business processes as well as the growing sense of data-driven decision-making. Whereas advanced technology boosts its popularity and new cycles come to the line, some have questions concerning when data scientist jobs become obsolete for the next five years. In this article, we discuss if the data science jobs stay ahead in the next 5 years.
Growing Data Complexity
Considering the rise of digital devices and IoT (the Internet of Things) the complexity of data generated will continue to rise exponentially. With the intensified data complexity faced by organizations, there are both challenges and chances inherent in the process that eventually led to the state wherein data scientists are needed to extract these actionable insights from a set of large and diverse volumes of data.
Expanding Use Cases
Data science is no longer just a limited field of work but has emerged to be a key practice of commerce in almost every industry including healthcare, finance, retail, etc. As companies realize the power of evidence-based decisions, the demand for data science expertise is projected to go beyond just industry to brands, thereby stirring the growth of data science roles even further.
Let us mention that one of the major factors is the progress in the sphere of Psychological Warfare and Deep Fakes. AI and ML are being used the most in the data science field all over the world and thus enterprises can automate processes, strengthen forecasting, and get so many ways of understanding the data. As the market grows and more companies introduce AI and ML applications into their businesses, the main need will be for trained data scientists and analysts working on these problems to remain current.
Shortage of Skilled Talent
Regardless of the increasing number of data science positions that are expected to be employed, there is still a lack of enough trained talent in the field. According to the various sector reports, the existing gap between the data science industry professionals and the demand is massive, with employers being unable to recruit candidates with the right experience and skills. Data science professionals are projected to be in high demand coming years as this skill gap is anticipated to extend into the foreseeable future.
Emerging Technologies and Trends
Nonetheless, the requirement of data science jobs will undoubtedly ensue just as the technology and skills needed to perform the roles are set to advance or change. Technologies like cloud computing, big data analytics, and blockchain are going to rise and they may reshape the skills and the way experts approach data science in the future. Data scientists who have competencies in an array of the latest technologies, and know the current trends, will fill the jobs that already exist and the new positions that will come as a result of constant changes in the job market.
Conclusion
The high demand for data science jobs in the next five years and years beyond will remain strong. Organizations that use data to invent and become leaders in the market, will become more and more reliant on data scientists who can get insights from big and complicated data sets. Nevertheless, the technological world is moving very fast, thus, staying relevant in data science will require continuous learning and embracing new technologies and trends.

Supporting Every Step: The Science Behind Orthotic Footwear

Reading Time: 3 minutesOrthotic footwear has revolutionised the way we approach foot health and comfort. From athletes seeking peak performance to individuals suffering from various foot ailments, orthotic shoes offer a solution that goes beyond mere fashion. In this comprehensive guide, we delve into the science behind orthotic footwear, exploring how these specialised shoes provide support, alleviate discomfort, and promote overall foot health.The complexity of the human foot The foot is comprised of over 100 muscles, tendons, and ligaments. It contains 33 joints and 26 bones. It is an amazing piece of engineering. Its primary functions include supporting the body’s weight, absorbing shock during movement, and facilitating locomotion.However, various factors, such as genetics, biomechanics, and lifestyle choices, can lead to foot-related issues. These issues range from common conditions like flat feet and high arches to more severe problems such as plantar fasciitis and bunions. Orthotic footwear addresses these concerns by providing tailored support and alignment to promote optimal foot function.The science behind orthotic footwearOrthotic footwear is designed based on principles of biomechanics, which involve the study of the body’s movement and the forces acting upon it. By understanding how the foot interacts with the ground during walking, running, and other activities, orthotic specialists can develop shoes that correct biomechanical abnormalities and mitigate stress on the feet.One of the key components of orthotic footwear is the insole or footbed. Most of the time, these insoles are made of foam, gel, or thermoplastics. They are meant to soften, support, and stabilise your feet. Additionally, they may incorporate features such as arch support, metatarsal pads, and heel cups to address specific foot issues.Arch support is especially important for people whose arches have fallen or their feet are flat. Shoes with built-in arch support that are orthotic help spread the body’s weight more evenly across the foot. This takes pressure off the arch and makes the pain go away. In the same way, metatarsal pads can ease pressure on the balls of the feet, and heel cups can support and cushion the heel.Also, orthotic shoes often have motion control tools that can fix overpronation or supination. If your foot rolls inward too much while you walk, you have overpronation. This can lead to a number of issues, including heel fasciitis and shin splints. Orthotic shoes with motion control features aim to stabilize the foot and prevent excessive pronation, thus reducing the risk of injury.Benefits of orthotic footwearOrthotic shoes are useful for more than just comfort. Orthotic shoes can make a big difference in the quality of life for people with long-term foot problems like plantar fasciitis, arthritis, or diabetes by lowering pain and making it easier to move around. These shoes keep your feet from getting hurt more and help them heal faster by giving them the right support and balance.Athletes and active individuals also stand to benefit from orthotic footwear. By optimising biomechanical alignment and reducing stress on the feet, orthotic shoes can improve performance and reduce the risk of injuries. Whether running, walking, or participating in sports, wearing orthotic footwear can enhance stability, balance, and efficiency of movement.Moreover, orthotic footwear is not limited to adults. Children with developmental issues or foot abnormalities can benefit from orthotic shoes specially designed to support growing feet and promote healthy development. By addressing alignment issues early on, orthotic footwear can prevent future complications and ensure proper foot function throughout life.Choosing the right orthotic footwearWhen selecting orthotic footwear, it’s essential to consider factors such as foot type, activity level, and specific foot conditions. Consulting with a podiatrist or orthotic specialist can help determine the most suitable shoes for individual needs. Additionally, undergoing a gait analysis can provide valuable insights into biomechanical imbalances and guide the selection process.It’s also crucial to ensure proper fit when purchasing orthotic footwear. Ill-fitting shoes can exacerbate foot problems and lead to discomfort or injury. Many kinds of custom shoes come in different widths and sizes to fit feet of all shapes and sizes. If you want to know if shoes are comfortable and fit well, you should walk around in them before you buy them.TakeawayOrthotic footwear represents a significant advancement in foot care, offering tailored support and alignment to address a wide range of foot issues. By applying principles of biomechanics and engineering, orthotic specialists have developed shoes that not only provide comfort but also promote overall foot health and functionality. Whether seeking relief from pain, enhancing athletic performance, or ensuring healthy foot development, orthotic footwear offers a solution for individuals of all ages and lifestyles. With continued research and innovation, the future of orthotic footwear holds promise for further advancements in foot health and well-being.Adam Mulligan, a psychology graduate from the University of Hertfordshire, has a keen interest in the fields of mental health, wellness, and lifestyle.