Liver acid could be ‘elixir’ to extend life, scientists say

Your support helps us to tell the storyFrom reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it’s investigating the financials of Elon Musk’s pro-Trump PAC or producing our latest documentary, ‘The A Word’, which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story.The Independent is trusted by Americans across the entire political spectrum. And unlike many other quality news outlets, we choose not to lock Americans out of our reporting and analysis with paywalls. We believe quality journalism should be available to everyone, paid for by those who can afford it.Your support makes all the difference.CloseRead moreA type of bile produced by the liver has similar effects as the commonly followed method of calorie restriction in promoting longevity, Chinese scientists have found.In a new study, published in the journal Nature on Thursday, the scientists assessed the effects of lithocholic acid, or LCA, in genetically modified mice with human tissues and compared them to calorie restriction.They found that LCA, which is naturally produced by the liver, can boost muscle regeneration and enhance grip strength and running capacity. Previous research has shown that mammals accumulate LCA during calorie restriction and it activates a key molecule involved in metabolism called AMP-activated protein kinase, or AMPK.AMPK, which is activated when the glucose levels drop, is key to ageing as it regulates processes like inflammation and nerve degeneration. In experiments on fruit flies and a nematode called C elegans, the scientists found LCA activates AMPK and induces anti-ageing effects in a manner similar to calorie restriction. Since these animals do not synthesise LCA naturally, the research indicates that they gain the effects of LCA once administered.Nematode worm C elegans

The best of Hell World 2024

Man 2024 was a great year! No not any single thing that happened in the world, I mean all the writing and reporting from our talented lineup of Hell World contributors. Today I thought we’d take a look back at the best stuff written here over the past year by people who are not me.…

The global rise of the far-right is coming home to Canada

As governments across Europe and the United States have been taken over by far-right parties, it becomes increasingly clear that centrist and progressive politics have failed to address the expanding inequality of the last four decades. This inequality has been effectively documented by scholars, including Thomas Piketty and Mark Blyth.  Here in Canada, the centrist Liberals are struggling in…

First trailer for James Gunn’s new Superman movie released

The first trailer for James Gunn’s much-anticipated Superman movie has been released.Starring David Corenswet as Superman/Clark Kent and Rachel Brosnahan as Lois Lane, the film is being heralded as a significant reset for the DC movie universe (DCU), of which Gunn became joint CEO in 2022.Opening with a sequence featuring Krypto, the Man of Steel’s hallowed superdog, the trailer gives little away in terms of plot – other than that Lex Luthor (played by a shaved-head Nicholas Hoult) is heavily involved, as well as a fire breathing dragon. Superman also appears to incur the wrath of the civilian population, with one disgruntled citizen beaning him on the back of the head with a disposable cup.Having outlined his ambitious plans for the newly minted DCU in 2023, Gunn’s film – originally entitled Superman: Legacy – is to be the first instalment of a series entitled Chapter One: Gods and Monsters, which is also due to include movies centring on Supergirl, Clayface and Swamp Thing.Superman is due for release on 10 July in Australia, and on 11 July in the US and UK.

Superman fans delighted as beloved character features in new movies first trailer

Your support helps us to tell the storyFrom reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it’s investigating the financials of Elon Musk’s pro-Trump PAC or producing our latest documentary, ‘The A Word’, which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.At such a critical moment in US history, we need reporters on the ground. Your donation allows us to keep sending journalists to speak to both sides of the story.The Independent is trusted by Americans across the entire political spectrum. And unlike many other quality news outlets, we choose not to lock Americans out of our reporting and analysis with paywalls. We believe quality journalism should be available to everyone, paid for by those who can afford it.Your support makes all the difference.CloseRead moreThe first trailer for the highly anticipated new Superman film from director James Gunn has arrived and fans of the comic book hero are ecstatic that a beloved character was included in the preview. The new film, which is just called Superman, will see David Corenswet take up the mantle of the Man of Steel as DC Studios looks to reboot its movie output under the vision of Gunn.The first snippet was shared on Thursday (19 December) and sees Corenswet in action for the first time as the Last Son of Krypton. Although the trailer doesn’t give much away about the story nearly all the key characters are shown including Lois Lane (Rachel Brosnahan), Lex Luthor (Nicholas Hoult), Guy Gardner (Nathan Fillon), Hawkgirl (Isabela Merced) and Mr Terrific (Edi Gathegi).However, the one character that everyone is talking about is Krypto the Superdog, Superman’s pet dog, who has many of the same powers as his owner. In the trailer, Krypto is seen rescuing Superman as he’s seen lying bloodied in the snow, presumably near Superman’s base in the Arctic, otherwise known as the Fortress of Solitude.Gunn wrote in his post about the trailer: “Here you go: the Superman trailer. Krypto, take us home.”Soon enough Krypto’s name was trending, with many fans expressing their delight at seeing the four legged friend in the teaser trailer. Clerks and Mallrats director, Kevin Smith said: “Good boy, Krypto! Great boy, @JamesGunn!”DC Comics writer Tom King, simply added: “Hell yeah”.Another enthusiastic fan wrote: “THEY GOT KRYPTO IN THIS? I have got the biggest smile on my face right now.”A third person wrote: “I truly don’t know why anyone ever doubts James Gunn. The #Superman trailer feels every bit like the triumphant new era for DC that this movie needs to be. David Corenswet exudes Big Superman Energy. And you just know Gunn is going to make you fall in love with Krypto. Excellent.”Watch Apple TV+ free for 7 daysNew subscribers only. £8.99/mo. after free trial. Plan auto-renews until cancelledTry for freeWatch Apple TV+ free for 7 daysNew subscribers only. £8.99/mo. after free trial. Plan auto-renews until cancelledTry for freeMeanwhile, a fourth person joked: “Let’s be real the best part of that trailer was Krypto. THAT’S MY BOYYYYYYYYYY”Krypto the Superdog in ‘Superman’

Florida is prone to floods. Where is our protective tech? 

As Florida recovers from another devastating hurricane season, recovery and rebuilding are top priorities for many residents. However, there is one important step in the process that many home and business owners continue to overlook at their own expense – flood mitigation.Neglecting flood mitigation perpetuates a continuous cycle of flood loss and recovery. To give you an example of how serious the problem is in Florida, a Jacksonville home holds the record for most federally funded rebuilds with 21 claims.Flood mitigation is a relatively new industry and much of the nation is stuck in a “sandbag” mentality when it comes to protecting their homes from flooding. Over the past 20 years, the flood mitigation industry has experienced exponential growth and innovation. The sandbags of yesteryear have been replaced with professionally engineered and thoroughly tested flood mitigation systems – many of them manufactured in Florida, including at the Jupiter-based Flood Panel. Such systems are designed to protect everything from family homes and small businesses to hospitals, power plants and schools.National Weather Service doesn’t mention flood mitigationThe industry is so new that the National Weather Service doesn’t mention flood mitigation in its advice on what to do to strengthen your home before a tropical storm or hurricane, instead providing tips to board up your windows, bring your patio furniture inside, and keep trees around your home trimmed — all good tips, but none to keep floodwaters from damaging your home.Opinion:Florida isn’t alone in its home insurance crisis. We must reimagine the system.Flooding causes more damage annually than any other natural disaster, equating to billions of dollars in property damage. Building structures that are properly protected from flooding costs slightly more, but the additional expense will ultimately benefit communities in case of future flooding events. According to the National Institute of Building Sciences, every dollar invested in flood mitigation will save you $6 compared to the cost of recovery.In Jacksonville, Palm Beach and Miami, flood mitigation systems protect businessesIn Jacksonville, Palm Beach, Miami, the Keys and everywhere in between, I have met with home and business owners whose properties were protected from the flooding following hurricanes. Those businesses that invested in effective flood mitigation systems reopen to customers as quickly as the next day. Those businesses not protected face weeks or months planning their next steps or awaiting federal dollars to rebuild and losing revenue each day that they are closed. The devastation is heartbreaking, even for someone who has witnessed it hundreds of times.   So, why don’t more property owners use modern flood mitigation systems? One issue is a lack of awareness of the range of flood mitigation solutions available and their effectiveness in protecting their most significant investment. Another reason is a reluctance to invest in protection. Flood mitigation is a lot like preventative care in medicine – those who get regular check-ups, immunizations, and screening are likely to catch issues before they become serious problems. Proper flood mitigation is like immunization for your home or business. Lastly, there is “flood amnesia,” a tendency for communities to forget about the impacts of flooding over time.Opinion:The connection between hurricanes and investment in FloridaAn important step in this process is educating lawmakers and changing the policy mindset that emphasizes flood recovery rather than flood mitigation. How many hurricane seasons will it take before Florida lawmakers realize that investing in flood mitigation now will protect communities, safeguard our infrastructure, and save taxpayer money? Florida’s economy is the fourth largest in the United States, roughly equivalent to the gross domestic product of Spain, which makes it critical to the financial well-being of our country.Clearly, hurricanes and tropical storms are becoming increasingly frequent and more severe, which makes flood mitigation even more important in the future. We owe it to Florida home and business owners, our state, and our nation to break this cycle of devastation and recovery and be more forward thinking in protecting our vital assets.Christopher Rodriguez is a flood mitigation specialist and a territory manager for Floodproofing.com in Jupiter.

How China’s Antitrust Tactics Undermine U.S. Tech Leadership

Argument

An expert’s point of view on a current event.

How China’s Antitrust Tactics Undermine U.S. Tech Leadership

U.S. firms are caught in China’s regulatory crossfire, with billions at stake.

By Ruby Scanlon, a research assistant at the Center for a New American Security, where she researches U.S.-China technology competition, artificial intelligence, and national security.

A photo of the Nvidia headquarters in Santa Clara, California. A black and green sign with the word Nvidia on it is in the foreground.

A photo of the Nvidia headquarters in Santa Clara, California, on on May 21, 2024 in . Justin Sullivan/Getty Images