NH Gov. Chris Sununu Lauds ePropelled for Creating New Opportunities in Aerospace 3.0 and High-Tech Manufacturing

LACONIA, NH –  ePropelled, Inc., a leading innovator in advanced electric power and propulsion for efficient, sustainable, and high-performance uncrewed systems across air, land, and sea, hosted New Hampshire Gov. Chris Sununu on Dec. 13 in Gilford, NH for a far-ranging demonstration of its USA-manufactured unmanned aerial vehicle (UAV) propulsion solutions.

Gov. Sununu lauded the success of ePropelled as an important contributor to high-technology manufacturing in the aerospace sector in the Granite State. “New Hampshire has always been strong in aerospace,” said Gov. Sununu. “But this is next-generation aerospace. This is like aerospace 3.0, if you will. High-tech manufacturing is our economic driver. Tourism and high-tech manufacturing work hand-in-hand. But our high-tech manufacturing has always worked around the aerospace field, and now right here in Laconia.”

After seeing the high-performance, brushless UAV electric motors and controllers in action, Gov. Sununu said: “To see what’s coming out of ePropelled right now is just awesome. Homegrown, great ideas, and real technology that has a real-world use. Not something theoretical; theoretical stuff is fine. But this is really happening on a world-wide stage. It’s a huge market and this is just the ground floor.”

ePropelled propulsion solutions are designed to provide global makers of UAVs with a high-quality alternative to Chinese drones and components. The commercial and defense drone industries worldwide have been reliant on China-made UAV technologies, but ePropelled’s motors, generators, and intelligent controllers – assembled in New Hampshire – provide an immediate option to replace them.

ePropelled offers compact UAV propulsion systems engineered to deliver enhanced thrust efficiency from 2.2 kg to 4.8 kg, longer drone flight ranges, and reduced operational costs. Sununu saw all three Series of ePropelled’s high power drone motors Sparrow Series and Falcon Series along with the Hercules Series of UAV starter generators.

ePropelled Sparrow UAV Motor APM40

“I’m a little bit of a nerd, and I nerd out over this really advanced technology,” said Gov. Sununu. “And it’s not something that isn’t applicable, whether you’re talking about a home use in a done that kids are using, or something on the world stage with military applications.”

ePropelled has been rapidly expanding its new manufacturing facility, located at 144 Lexington Drive, Laconia, NH 03246, to meet the surging demand for UAV systems. The global UAV propulsion systems market is expected to grow from $6.17 billion in 2024 to $8.19 billion by 2029, reflecting a CAGR of 5.84 percent, according to a recent report by Mordor Research.

ePropelled UAV propulsion system water resistence demo

“ePropelled is going after these markets, and the markets are responding, which is just so cool,” said Sununu. “ePropelled is a young company that is cash-flow positive, that’s doing so well, and that’s hiring like crazy. So, if you’re interested in the next generation of real-world technology, it’s happening right here in Laconia. I love it, I couldn’t be more proud. Congratulations.”

Nick Grewal, CEO of ePropelled, said: “Our Sparrow product line exemplifies ePropelled’s commitment to innovation and excellence in USA-based propulsion technology. As the global regulatory landscape shifts, ePropelled provides cutting-edge drone solutions that not only meet the most stringent industry requirements, but also help our customers stay ahead of compliance challenges with products fully assembled in the USA.”

By boosting the local economy and expanding the manufacturing base of the Lakes Region, Gov. Sununu expressed enthusiasm for ePropelled’s decision to establish and expand its manufacturing hub in New Hampshire. Gov. Sununu highlighted the strategic benefits of the state’s business environment, skilled workforce, and commitment to innovation in emerging technologies.

“New Hampshire as a whole – you see people coming in. Families want to be here, not just for our incredible quality of life, but for the high-tech experiences that used to be only reserved down in Cambridge and Boston; not anymore. We’re the tax-free suburb of high-tech manufacturing and that’s what Laconia is providing,” said Gov. Sununu. “You can have the incredible high-quality, low-cost of living, and have the high-tech experience right here. That’s the new world of opportunities that people like Nick Grewal and ePropelled are bringing.”

The new and growing Laconia facility is designed to support the surging demand for ePropelled’s industry-leading electric propulsion systems for UAVs, serving customers across sectors like defense, aerospace, and logistics. The facility features advanced manufacturing processes and the latest automation technology, ensuring high-quality, efficient production to meet the increasing demand for clean energy propulsion systems.

“The expansion of our Laconia facility represents an important milestone in our company’s mission to revolutionize electric propulsion,” said Grewal. “We are excited to be part of New Hampshire’s vibrant innovation ecosystem and look forward to driving growth in both the UAV industry and the local economy. Our investment in Laconia will create new job opportunities and contribute to the region’s growing prominence in advanced manufacturing.”

With this facility, ePropelled aims to create a sustainable future for aviation by providing high-performance, energy-efficient electric motors that reduce the carbon footprint of UAVs and in other aerospace applications. The Laconia facility is expected to generate significant local employment, further strengthening New Hampshire’s position as a hub for innovation in advanced aerospace technology. Additionally, the company plans to collaborate with local educational institutions to support the development of a skilled workforce in the aerospace and advanced manufacturing sectors.

About ePropelled

Based in Laconia, NH, USA, ePropelled, Inc. delivers advanced electric power and propulsion, delivering efficient, sustainable, and high-performance solutions for autonomous systems across air, land, and sea. ePropelled is Uncrewed, Unlimited: Powering the Future of Multi-Domain Autonomous Systems. Founded in 2018, ePropelled serves more than 40 customers worldwide and operates from its New Hampshire headquarters, test facility, and manufacturing center, supported by R&D and operations facilities in the United Kingdom and India.

ePropelled products are engineered to optimize performance, reduce energy consumption, and support the speedy transition to a sustainable future. For more information, contact ePropelled at [email protected], call 603-236-7444, or visit https://epropelled.com.

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John Krull: Books and the pages of time

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One of life’s underrated pleasures is that of reading an old, old book.For the past few days, I’ve been working my way through an aged copy of Ralph Waldo Emerson’s “Representative Men.”This particular volume I picked up at a used bookstore in Concord, Massachusetts. Its artfully ribbed spine caught my eye when it sat on the shelf. When I plucked it from its spot, its decorated leathery cover and pleasing heft seduced me.
It was published as part of a set of Emerson’s works by a London house, George Routledge and Sons, Limited, in 1899. On the inside of the front cover, there is a bookplate—presumably from the original owner, one Elisha Rhodes Brown.A little bit of research told me that Brown was born in Providence, Rhode Island, on March 28, 1847. He was part of the family that helped build Providence and lent its name to Brown University.He migrated to Dover, New Hampshire, late in his adolescence. He worked for a short time as a printer, then briefly clerked in a store before becoming a teller at the Stafford National Bank.From that perch, he climbed the ladder until he became president of the bank when he was 50, a position he held until he died on Christmas Day, 1922, when he was 75.The most prevalent photo of him shows a severe-looking gentleman wearing wire-rim glasses and a dark suit of material that looks as heavy as a tarp. His hair is parted in the middle, and he has a trimmed Lincoln-style beard with no moustache.He looks every inch the sober 19th-century man of business.He must have been a bookish fellow, too. Emerson’s writing never has been the stuff of light diversion.I haven’t read Emerson since my graduate school days decades ago.Back then, I didn’t care much for Transcendentalism’s sage. His almost promiscuous use of semi-colons made his prose seem distant and affected, so arch that it made it difficult for me to engage with his thinking.Now, though, that I’ve moved to a later season of my life, I find Emerson’s style less dense and more inviting. This makes it easier to appreciate his insights, the movement of his agile mind at work and at play.His breakthrough thought, of course, was a sense that the divine was not something separate from us, but something all around us and part of us. In other words, God was transcendent, embodied in every aspect of creation.Thus, he elevated a walk in the woods to being a spiritual act. A hike became an ambulatory form of prayer.Emerson’s inclusive theology sparked a kind of revolution in the 19th century, one that spread across the faith traditions and lingers to this day.

Andrew Garfield says he filmed ‘most embarrassing sex scene of all time’ with Florence Pugh

Andrew Garfield and Florence Pugh experienced “the most embarrassing” sex scene ever together while filming We Live in Time. The romantic comedy follows the story of a couple’s ten year relationship from their surprise meeting, to the unconventional journey they embark on together. Told in a non-linear format, the tale of their relationship shows the…

Americans are reading less — and smartphones and shorter attention spans may be to blame. 7 tips to help you make books a joyful habit.

There’s something special, even magical, about getting lost in a good book. But for a growing number of Americans, both adults and adolescents alike, interest in reading books — and the stamina it can take to finish them — is waning.An Economist/YouGov poll of 1,500 Americans found that 46% didn’t finish any books last year, and it’s part of an ongoing trend: A 2023 National Endowment for the Arts report called out the “sharp decline” in reading over the last decade. Americans now read an average of 12.6 books per year, according to a 2022 Gallup poll — “a smaller number than Gallup has measured in any prior survey dating back to 1990.” The biggest shift is in “the most voracious readers” — college graduates, women and older Americans — who are still reading, but the amount of books has dwindled.As writer Jeremy Anderberg, who reviews books on his Substack Read More Books, puts it: “We’re reading more words than ever before, but we’re reading fewer books.”AdvertisementAdvertisementAdvertisementNewsletter: The YodelTrusted news and daily delights, right in your inboxSee for yourself — The Yodel is the go-to source for daily news, entertainment and feel-good stories.That doesn’t mean people aren’t buying books — in fact, Barnes & Noble is making a comeback, opening more than 60 new locations, and Publishers Weekly is reporting a 7% increase in industry-wide sales this year — but they aren’t necessarily reading them. (There’s even a Japanese name for people who buy books and never get around to reading them: tsundoku.) In trying to understand it, one writer quipped: “Our eyes have been bigger than our attention spans.”Teachers are also seeing a generational shift in the reading habits of students, including some Gen Z-ers who reportedly don’t view reading as important. Younger students are impacted too: An Education Week Research Center survey asked educators how the reading stamina of students in third through eighth grade has changed since 2019. The survey found that 53% reported that reading stamina in students decreased a lot and 30% said it decreased a little, compared to only 10% saying it increased a little or a lot. Meanwhile, professors are saying that students are arriving at college unprepared, baffled and overwhelmed by having to read multiple books cover-to-cover.Why are people reading less?There are several reasons why reading books is on the decline. But a big part of the problem is likely staring you in the face right now: your smartphone. Along with TV, smartphones unlock a constant stream of dopamine-inducing content and allow you to immediately switch to something else the second whatever you’re doing gets remotely boring. It’s often too tempting to resist — and along with the constant notifications, it’s impacting our attention spans. Even the mere presence of a smartphone is distracting. “We’re a country addicted to our smartphones and we all know it,” Anderberg tells Yahoo Life.Jen Miller, a middle school librarian who talks about books to her more than 670k followers on TikTok, agrees. “In a time when there is so much for us to consume and it’s all right at our fingertips, usually on our phones, it is easy to opt for the immediate gratification of scrolling on social media or streaming a show,” she tells Yahoo Life.AdvertisementAdvertisementAdvertisementIt doesn’t start out that way, though. Kathryn Starke, a national literacy consultant, reading specialist and founder of Creative Minds Publications, says that every young child is “naturally excited” about learning to read. “However, if a child struggles to learn to read or is not presented with a variety of engaging and interesting books, they often stop reading,” she tells Yahoo Life. “I believe that fewer adolescents and adults are reading books because of the above points, which begin in elementary school. I also believe that you have to make time to read books, and many people — especially adolescents — put their time elsewhere.”What counts as actual reading is also changing. “I think both adolescents and adults think reading something quickly on your phone, tablet or social media is equivalent to reading a book when, in fact, it’s actually often skimming and scanning information or stories,” says Starke. Shorter attention spans cause more people to want to read quickly, she says, which only makes sustaining longer books more of a struggle.Students are increasingly using individual computers at school where, she says, they’re reading a variety of short digital texts and not entire novels or books. “Reading stamina must be built often, so if students aren’t learning how to read entire books at home or school, that habit often carries into adulthood,” she says.The surprising benefits of reading booksNot reading means missing out on a slew of benefits, beyond boosting language skills and vocabulary: It’s basically a workout for your brain. Engaging in reading keeps your memory and critical thinking skills sharp and fosters problem-solving. It also lowers your heart rate, reduces stress and eases muscle tension. Curling up with a book before bed can help you sleep better. It can even help you live a longer life; one study found that book readers had a 20% lower risk of dying over the next 12 years compared to non-book readers thanks to the cognitive engagement books provide.AdvertisementAdvertisementAdvertisementAnd that’s just scratching the surface. “It broadens our horizons,” Nadia Odunayo, founder and chief executive officer of the StoryGraph, which offers personalized recommendations based on your reading history, tells Yahoo Life. “It teaches us things. It makes us more empathetic, as we step into different characters’ shoes. It provides an escape from our day-to-day, so it’s good for our mental health and well-being.”Miller echoes that sentiment: “Reading is an escape and a time to relax.”She quotes Dr. Rudine Sims Bishop’s metaphor of reading as a mirror, window and sliding glass door: “Reading helps the reader see themselves in books, which is empowering and validating. Reading also allows the reader to build empathy while reading about others’ life experiences that are much different than their own. It provides a window into someone else’s world. And reading also allows for that escape to enter another world for a time, letting the world they are in disappear for a little while.”7 tips on how to read more booksWant to try reading more? “The obvious answer is to put down your phone and pick up a book,” says Anderberg. “It’s easy to say, but it’s very hard.” Instead, putting a few strategies in place makes it more likely that you’ll actually reach for a book — rather than your smartphone or TV remote — and carve out some time to read. Here are some suggestions that experts swear by:Find your matchThink you’re not much of a reader? It’s more likely that you just haven’t found the right book. “When I have a reluctant reader approach me about getting a book, I try to find their match,” says Miller. “My thought is that individuals that do not like to read just have not found the right book for them.”AdvertisementAdvertisementAdvertisementMiller knows that firsthand. Her students are typically “shocked” to learn that she didn’t find books she liked and that resonated with her until she graduated from school. “I think people assume that as a librarian, I have always loved to read, when in fact, I did not start reading for pleasure until I was an adult,” she shares. “It just took the right book to start me down a path of reading and then ultimately the path to librarianship.”It’s harder for adolescents who are mainly reading what’s assigned to them in school. But when students have the opportunity to choose their books and read for pleasure, Miller says that increases the chances that they’ll find genres they click with and ultimately enjoy reading. “Finding that joy in reading is so important for keeping readers and avoiding the drop-off in reading that occurs for many young people after elementary school,” she says.Anderberg agrees, explaining that if you can learn to cultivate your love for reading, then you won’t have to discipline yourself to read. “You’ll want to pick up a book because you’re interested and want to turn the page to find out what happens next,” he says.Starke says that “there is the perfect book for every reader.” So how to begin finding it? She recommends starting by figuring out your favorite genre or topic of interest and visiting the library to check out at least three to five books that match. Most libraries give you two to four weeks to read a book, so Starke says the time crunch can help motivate readers who want to know the ending of a book before having to hand it in.AdvertisementAdvertisementAnderberg also recommends sampling a whole bunch of books. “Find those airport bestsellers — try out pop history, murder mysteries or rom-coms — to find what you like,” he says. “You’ll know it when you find it because you’ll want to sit down and read it.”For seasoned readers who find themselves in a slump, return to a book you loved in the past. “Curl up with an old favorite,” Suzanne Skyvara, vice president of marketing and editorial at Goodreads, tells Yahoo Life. “It’s like comfort food for your brain.”And don’t be afraid to ditch a book you don’t likeNo reading strategy will stick if you’re slogging through an unenjoyable book — and really, unless you’re a student on assignment and have no choice, life’s too short for that. “Stuck on a book that’s just not clicking? Don’t let it derail you,” says Skyvara. “It’s totally OK to put it down and try something else. There are so many amazing stories out there waiting for you.”Anderberg’s rule of thumb before quitting a book: “100 minus your age is how many pages to give a book” before deciding it isn’t for you. “If I’m not feeling it, I feel free to put it down.” Maybe you’ll revisit it later or maybe you’re too busy for this particular book or you’re not in the right headspace, he says, adding: “Your mood and circumstance have to fit the book sometimes and when those don’t match, it’s OK to put the book down.”AdvertisementAdvertisementAnd if you feel guilty about it, remember this: You’ve already supported the author by buying or checking out the book.Schedule in reading timePut time on your calendar to read each day, suggests Odunayo. “It can be just five to 10 minutes, but have it there and stick to it,” she says. “Work your way up to a focused hour of reading each day.”If an hour isn’t realistic for you, find an amount of time that works. For Atomic Habits author James Clear, it’s reading 20 pages first thing in the morning every day. Anderberg, who reads more than 100 books a year, also has a reading routine. “I wake up before the kids, make a cup of coffee and read for 30 to 45 minutes,” he says. “And at night, I read for 30 minutes before lights out. It’s an hour a day every day.”AdvertisementAdvertisementHe recommends aiming to carve out 30 minutes to read daily, whether it’s over a lunch break or sometime in the middle of the evening or if that’s not possible, binge reading over the weekend. “You can even set a timer on your phone or watch for 30 minutes and say, ‘It’s OK for me to not pay attention to my phone or computer for the next 30 minutes, and I’m not going to stop until the timer is up,” he says. “It’s going to be very hard at first, but as you practice it gets easier and easier.”Take your book to goAssume the identity of a reader, suggests Odunayo. “When you go out, always have a book or e-reader on you,” she says. That will help you take advantage of the surprising number of daily, hidden opportunities to squeeze in some reading time, whether it’s cracking open a book while waiting in line at the post office or while on eternal hold with your cable company. Having your book with you means you can easily fit in a mini-reading session while making the time pass by faster.Or create an easy-to-follow rule around reading: “I have a rule right now where whenever I’m commuting or on the subway or on a bus, I say to myself, ‘You cannot use your phone. You have to read,’” says Odunayo.Read with othersJust as you’re more likely to show up at the gym or yoga class if a friend is meeting you there, you’re more likely to crack open a book if people are counting on you to read it. “Starting a book club with family, friends or neighbors is another great way to ensure that you are reading a whole book,” says Starke. “Then you are rewarded with the opportunity to gather socially and share — book-themed décor and snacks are always encouraged.”Set goals and challenge yourselfThere’s nothing quite like a challenge to fire up that motivation. “A fun way to motivate yourself to read is the Goodreads Reading Challenge,” Skyvara says. “You set your own goal — most people aim for 11 to 25 books a year, or about one to two per month. It’s so satisfying to mark books as read and watch your progress bar move closer to your goal. And don’t worry; if life gets crazy, you can always adjust your goal so you maintain your motivation.”AdvertisementAdvertisementOr simply set a stretch goal: Whether it’s reading a few extra sentences or five more pages than you normally would or striving to complete a chapter, setting goals that allow you to stretch yourself can help improve reading stamina. Choosing a book series is another effective way to keep reading and rereading, says Starke, “thus building the stamina to read more and more lengthier books.”Model being a readerIf you’re a parent, one of the best ways to encourage your kids to read more — along with choosing books, including comics and graphic novels, that align with their interests and passions — is to read more yourself. “They’re not seeing the adults in their lives reading,” says Anderberg. “There’s something very powerful when a kid sees you make a choice to sit down with a book instead of doing busywork or pulling out your phone.”

Pakistan dismisses US official’s warning over missile program

KARACHI, PAKISTAN —  Pakistan’s Foreign Ministry on Saturday dismissed as unfounded and “devoid of rationality” assertions by a senior U.S. official that its missile program could eventually pose a threat to the United States. Earlier this week, Deputy National Security Adviser Jon Finer said Pakistan’s development of long-range ballistic missiles made it an “emerging threat.”…

Armenian woman named Female Business Leader of the Year

Amalya Yeghoyan, Executive Director of the Gyumri Information Technologies Center (GITC), has been named the Female Business Leader of the Year (53 per cent jury vote, 24 per cent public vote) at the Emerging Europe Awards 2024 for her transformative efforts in empowering women through technology education.

By leading programmes that equip women, including displaced and marginalised individuals, with vital coding, business, and entrepreneurial skills, she has enabled many to achieve financial independence and stability, Emerging Europe reported.

Her unwavering advocacy for the role of technology in addressing poverty and inequality has inspired women across Armenia to pursue careers in high-tech fields, creating lasting social and economic change in the region.

Sasha Bezuhanova and Michaela Bakala, both also inspiring leaders, were second and third.

Unlock the Science of Deep Sleep and Memory Formation

Neurons in the neocortex: Slow-wave sleep strengthens the connections between them, supporting memory formation. Credit: © Charité, Sabine Grosser
Slow-wave sleep plays a crucial role in strengthening memory by enhancing synaptic connections in the brain, with new findings suggesting potential methods for boosting memory through targeted stimulation.
For nearly two decades, scientists have known that slow, synchronized electrical waves in the brain during deep sleep play a key role in forming memories. However, the underlying reason remained unclear — until now. In a new study published in Nature Communications, researchers from Charité – Universitätsmedizin Berlin propose an explanation. They found that these slow waves make the neocortex, the brain’s long-term memory center, especially receptive to new information. This discovery could pave the way for more effective memory-enhancing treatments in the future.
How Memories Form During Sleep
How do lasting memories form? Scientists believe that while we sleep, the brain replays events from the day, transferring information from the hippocampus, where short-term memories are stored, to the neocortex, where long-term memories reside. A key player in this process is “slow waves” — synchronized electrical oscillations in the cortex that occur during deep sleep. These waves, which can be measured with an electroencephalogram (EEG), happen when the electrical activity in large groups of neurons rises and falls together about once per second.
“We’ve known for many years that these voltage fluctuations contribute to the formation of memory,” explains Prof. Jörg Geiger, director of the Institute of Neurophysiology at Charité and the head of the newly published study. “When slow-wave sleep is artificially augmented from outside, memory improves. But what we didn’t know until now was what exactly is happening inside the brain when this occurs, because it is extremely difficult to study the flows of information inside the human brain.”
Slow waves, or slow oscillations, are a type of electrical wave arising in the brain during deep sleep. “Delta” waves comprise a certain frequency range that shows up in an EEG. These are slow brain waves that can arise outside sleep as well, as part of a disease or disorder. This broader term is sometimes used synonymously with the term “slow waves.”
Slow Waves Strengthen Synapses
He and his team have now used intact human brain tissue, which is extremely rare, to clarify the processes that are very likely to underlie the formation of memory during deep sleep. According to their findings, the slow electrical waves influence the strength of synaptic connections between the neurons in the neocortex – and thus their receptivity.
For their study, the team of researchers studied intact neocortical tissue samples taken from 45 patients who had undergone neurosurgery to treat epilepsy or a brain tumor at Charité, the Evangelisches Klinikum Bethel (EvKB) hospital, or the University Medical Center Hamburg-Eppendorf (UKE). The researchers simulated the voltage fluctuations typical of slow brain waves during deep sleep in the tissue and then measured the nerve cells’ response. To achieve this, they used glass micropipettes positioned precisely down to the nanometer. To “listen in” on the communications among multiple nerve cells connected through the tissue, they used up to ten “pipette feelers” at once – an extra large number for this method, which is known as the multipatch technique.
Ten “feelers” to track deep sleep: This friendly-looking microscope was instrumental in decoding the effects of the slow waves typical of sleep. Equipped with ten glass pipettes that can be controlled precisely down to the nanometer using robot arms, it can stimulate and read the electrical activity of just as many nerve cells in the connected tissue. Credit: © Charité, Franz Xaver Mittermaier
Perfect Timing Contributes to Memory Formation
The team of researchers discovered that the synaptic connections between neurons in the neocortex are maximally enhanced at a very specific point in time during the voltage fluctuations.
“The synapses work most efficiently immediately after the voltage rises from low to high,” explains Franz Xaver Mittermaier, a researcher at the Institute of Neurophysiology at Charité and the first author of the study. “During that brief time window, the cortex can be thought of as having been placed in a state of elevated readiness. If the brain plays back a memory at exactly this time, it is transferred to long-term memory especially effectively. So, slow-wave sleep evidently supports memory formation by making the neocortex particularly receptive for many short periods of time.”
Ten “pipette feelers” in use. Credit: © Charité, Yangfan Peng
Potential for Memory Improvement
This knowledge could be used to improve memory, for example in mild cognitive impairment in the elderly. Research groups around the world are working on methods of using subtle electrical impulses – transcranial electrostimulation – or acoustic signals to influence slow waves during sleep.
“Right now, though, these stimulation approaches are being optimized through trial and error, which is a laborious and time-consuming process,” Geiger says. “Our findings about the perfect timing could help with this. Now, for the first time, they allow for targeted development of methods of stimulation to boost memory formation.”
Reference: “Membrane potential states gate synaptic consolidation in human neocortical tissue” by Franz X. Mittermaier, Thilo Kalbhenn, Ran Xu, Julia Onken, Katharina Faust, Thomas Sauvigny, Ulrich W. Thomale, Angela M. Kaindl, Martin Holtkamp, Sabine Grosser, Pawel Fidzinski, Matthias Simon, Henrik Alle and Jörg R. P. Geiger, 12 December 2024, Nature Communications.DOI: 10.1038/s41467-024-53901-2
*Mittermaier F. X. et al. Membrane potential states gate synaptic consolidation in human neocortical tissue. Nat Commun 2024 Dec 12. doi: 10.1038/s41467-024-53901-2
About the Study
During surgeries for drug-resistant epilepsy or brain tumors, small fragments of the neocortex sometimes need to be removed for medical reasons. These resected tissue samples can remain viable for up to two days outside the body when preserved in an artificial nutrient solution. For this study, explicit patient consent was required to examine these valuable samples, and the research team expressed profound gratitude to the patients who participated.
The study was a collaborative effort, uniting basic research and clinical expertise. It involved Charité – Universitätsmedizin Berlin, the University Clinic for Neurosurgery at Evangelisches Klinikum Bethel (EvKB) in Bielefeld, and the Department of Neurosurgery at the University Medical Center Hamburg-Eppendorf (UKE). Led by the Institute of Neurophysiology, Charité’s contributions included the Department of Neurosurgery, the Department of Neurology with Experimental Neurology, the Institute of Integrative Neuroanatomy, the Neuroscience Research Center, the NeuroCure Cluster of Excellence, the Division of Pediatric Neurosurgery, and the Department of Pediatric Neurology.

Unlock the Science of Deep Sleep and Memory Formation

Neurons in the neocortex: Slow-wave sleep strengthens the connections between them, supporting memory formation. Credit: © Charité, Sabine Grosser
Slow-wave sleep plays a crucial role in strengthening memory by enhancing synaptic connections in the brain, with new findings suggesting potential methods for boosting memory through targeted stimulation.
For nearly two decades, scientists have known that slow, synchronized electrical waves in the brain during deep sleep play a key role in forming memories. However, the underlying reason remained unclear — until now. In a new study published in Nature Communications, researchers from Charité – Universitätsmedizin Berlin propose an explanation. They found that these slow waves make the neocortex, the brain’s long-term memory center, especially receptive to new information. This discovery could pave the way for more effective memory-enhancing treatments in the future.
How Memories Form During Sleep
How do lasting memories form? Scientists believe that while we sleep, the brain replays events from the day, transferring information from the hippocampus, where short-term memories are stored, to the neocortex, where long-term memories reside. A key player in this process is “slow waves” — synchronized electrical oscillations in the cortex that occur during deep sleep. These waves, which can be measured with an electroencephalogram (EEG), happen when the electrical activity in large groups of neurons rises and falls together about once per second.
“We’ve known for many years that these voltage fluctuations contribute to the formation of memory,” explains Prof. Jörg Geiger, director of the Institute of Neurophysiology at Charité and the head of the newly published study. “When slow-wave sleep is artificially augmented from outside, memory improves. But what we didn’t know until now was what exactly is happening inside the brain when this occurs, because it is extremely difficult to study the flows of information inside the human brain.”
Slow waves, or slow oscillations, are a type of electrical wave arising in the brain during deep sleep. “Delta” waves comprise a certain frequency range that shows up in an EEG. These are slow brain waves that can arise outside sleep as well, as part of a disease or disorder. This broader term is sometimes used synonymously with the term “slow waves.”
Slow Waves Strengthen Synapses
He and his team have now used intact human brain tissue, which is extremely rare, to clarify the processes that are very likely to underlie the formation of memory during deep sleep. According to their findings, the slow electrical waves influence the strength of synaptic connections between the neurons in the neocortex – and thus their receptivity.
For their study, the team of researchers studied intact neocortical tissue samples taken from 45 patients who had undergone neurosurgery to treat epilepsy or a brain tumor at Charité, the Evangelisches Klinikum Bethel (EvKB) hospital, or the University Medical Center Hamburg-Eppendorf (UKE). The researchers simulated the voltage fluctuations typical of slow brain waves during deep sleep in the tissue and then measured the nerve cells’ response. To achieve this, they used glass micropipettes positioned precisely down to the nanometer. To “listen in” on the communications among multiple nerve cells connected through the tissue, they used up to ten “pipette feelers” at once – an extra large number for this method, which is known as the multipatch technique.
Ten “feelers” to track deep sleep: This friendly-looking microscope was instrumental in decoding the effects of the slow waves typical of sleep. Equipped with ten glass pipettes that can be controlled precisely down to the nanometer using robot arms, it can stimulate and read the electrical activity of just as many nerve cells in the connected tissue. Credit: © Charité, Franz Xaver Mittermaier
Perfect Timing Contributes to Memory Formation
The team of researchers discovered that the synaptic connections between neurons in the neocortex are maximally enhanced at a very specific point in time during the voltage fluctuations.
“The synapses work most efficiently immediately after the voltage rises from low to high,” explains Franz Xaver Mittermaier, a researcher at the Institute of Neurophysiology at Charité and the first author of the study. “During that brief time window, the cortex can be thought of as having been placed in a state of elevated readiness. If the brain plays back a memory at exactly this time, it is transferred to long-term memory especially effectively. So, slow-wave sleep evidently supports memory formation by making the neocortex particularly receptive for many short periods of time.”
Ten “pipette feelers” in use. Credit: © Charité, Yangfan Peng
Potential for Memory Improvement
This knowledge could be used to improve memory, for example in mild cognitive impairment in the elderly. Research groups around the world are working on methods of using subtle electrical impulses – transcranial electrostimulation – or acoustic signals to influence slow waves during sleep.
“Right now, though, these stimulation approaches are being optimized through trial and error, which is a laborious and time-consuming process,” Geiger says. “Our findings about the perfect timing could help with this. Now, for the first time, they allow for targeted development of methods of stimulation to boost memory formation.”
Reference: “Membrane potential states gate synaptic consolidation in human neocortical tissue” by Franz X. Mittermaier, Thilo Kalbhenn, Ran Xu, Julia Onken, Katharina Faust, Thomas Sauvigny, Ulrich W. Thomale, Angela M. Kaindl, Martin Holtkamp, Sabine Grosser, Pawel Fidzinski, Matthias Simon, Henrik Alle and Jörg R. P. Geiger, 12 December 2024, Nature Communications.DOI: 10.1038/s41467-024-53901-2
*Mittermaier F. X. et al. Membrane potential states gate synaptic consolidation in human neocortical tissue. Nat Commun 2024 Dec 12. doi: 10.1038/s41467-024-53901-2
About the Study
During surgeries for drug-resistant epilepsy or brain tumors, small fragments of the neocortex sometimes need to be removed for medical reasons. These resected tissue samples can remain viable for up to two days outside the body when preserved in an artificial nutrient solution. For this study, explicit patient consent was required to examine these valuable samples, and the research team expressed profound gratitude to the patients who participated.
The study was a collaborative effort, uniting basic research and clinical expertise. It involved Charité – Universitätsmedizin Berlin, the University Clinic for Neurosurgery at Evangelisches Klinikum Bethel (EvKB) in Bielefeld, and the Department of Neurosurgery at the University Medical Center Hamburg-Eppendorf (UKE). Led by the Institute of Neurophysiology, Charité’s contributions included the Department of Neurosurgery, the Department of Neurology with Experimental Neurology, the Institute of Integrative Neuroanatomy, the Neuroscience Research Center, the NeuroCure Cluster of Excellence, the Division of Pediatric Neurosurgery, and the Department of Pediatric Neurology.