Donald Trump will be sworn in January 20 as the only U.S. president with felony convictions, and this week saw a flurry of activity over the court cases still open against him. On Friday, a New York judge is to sentence Trump in one case. VOA Senior Washington Correspondent Carolyn Presutti reports.This post was originally…
The groundbreaking initiative by the UK Biobank has been unveiled, aiming to conduct an expansive investigation into the intricate world of proteins found in human blood. This extensive study, heralded as the most significant protein research effort to date, seeks to provide key insights into how protein levels fluctuate throughout an individual’s mid-to-late life and how these variations are tied to the emergence and progression of various diseases. The scale at which this ambitious endeavor operates is unprecedented, with plans to analyze over 5,400 distinct proteins across 600,000 blood samples, making it a formidable undertaking in the realm of population proteomics.
The initial phase of this monumental project intends to investigate the first 300,000 samples, which encompass contributions from about 250,000 UK Biobank participants along with follow-up samples from 50,000 individuals collected up to 15 years later. By correlating the wealth of proteomic data with clinical information collected over such an extensive time frame, researchers hope to create a novel database that can shed light on the evolution of protein levels linked to various health outcomes. The implications of this research are vast, potentially leading to revolutionary advancements in disease diagnostics and therapeutic strategies.
Proteomics, the study of proteins and their functions, plays a pivotal role in understanding biological processes, particularly in revealing the connections between genetic predispositions and health outcomes. The UK Biobank’s previous pilot study, which provided data on approximately 3,000 circulating proteins, highlighted key associations between genetic variants and altered protein levels, the majority of which had not been documented before. This prior research laid a robust groundwork for the current initiative, demonstrating the power of proteomic analysis to expand our understanding of diseases ranging from cancer to neurodegenerative disorders.
As the range of diseases studied expands with the inclusion of the comprehensive proteomic dataset, researchers anticipate breakthroughs in identifying biomarkers that could herald early diagnosis. The project is not merely an academic pursuit, but rather an essential quest that has the potential to enhance preventive strategies and pinpoint therapeutic targets through the examination of how protein levels transform over time. The correlation between protein dynamics and age-related diseases, such as cardiovascular complications, diabetes, and neurodegeneration, exemplifies the importance of integrating proteomic studies into contemporary medical research.
The efforts to coordinate such an extensive dataset have attracted the attention of a consortium of fourteen leading biopharmaceutical companies, all of which are collaborating under the UK Biobank Pharma Proteomics Project. The funding provided by this coalition enables the undertaking of large-scale sample analysis with high-throughput technologies, which enhances the feasibility of such massive studies. Integration of resources from diverse sectors of the scientific community exemplifies a modern approach to tackling some of healthcare’s most pressing challenges through collaboration and shared knowledge.
A particularly exciting aspect of this proteomics study is the ability to cross-reference proteomic data with imaging findings. Nearly 100,000 participants in the UK Biobank have undergone detailed magnetic resonance imaging (MRI) scans of critical organs such as the brain and heart, enabling healthcare researchers to investigate the intersection of functional imaging with proteomic analytics. This multifaceted analysis will allow scientists to construct robust models that could elucidate the mechanisms underlying disease processes, leading to enhanced approaches to health monitoring and disease management.
Furthermore, the deployment of machine learning and artificial intelligence algorithms in parsing the extensive datasets being generated holds promise for significant advancements in the predictive capabilities of healthcare interventions. Utilizing AI to analyze the proteomic data in conjunction with genetic and imaging information could allow for the early identification of disease subtypes, ultimately paving the way for tailored treatments that integrate individual health variables. The potential for early disease detection represents a paradigm shift in how healthcare can be approached, moving from reactive to proactive management.
The research community’s enthusiasm for this project is palpable. Leading figures, including Professor Sir Rory Collins and Professor Naomi Allen, have expressed optimism regarding the transformative capabilities of proteomic data for enhancing public health. Insights gained from the longitudinal study of protein levels and their intricate interactions within biological pathways represent a leap forward in comprehending the triggers of chronic diseases and the biological underpinnings of aging.
Anticipation mounts as the first wave of results from the proteomics study will be accessible to approved researchers starting in 2026, with the entirety of the dataset expected to be fully operational by 2027. This staggered release schedule allows for a thorough examination of findings and the application of insights into clinical scenarios. Such careful management of data access embodies the principles of responsible research while fostering an environment conducive to innovation.
The technical execution of this proteomics analysis is being led by industry giants, with significant involvement from Regeneron Genetics Center and technological support from Thermo Fisher Scientific and Ultima Genomics, each bringing state-of-the-art methodologies to the table. As sample processing progresses, the integration of advanced sequencing platforms with high throughput methodologies is anticipated to yield substantial data that can illuminate new avenues for exploration within medical research.
In summary, the UK Biobank’s initiative epitomizes the vision of a future where personalized medicine could become a prevalent endeavor, guided by detailed insights from proteomic analyses. This monumental effort not only enhances the capacity for scientific exploration but stands to usher in a new era of health understanding, where the intricate relationships between proteins, genetic makeup, and disease progression are unraveled and utilized to improve patient outcomes across the globe.
Subject of Research: Proteomics and its impact on disease understanding and treatmentArticle Title: The Pioneering UK Biobank Proteomics Study: A New Dawn in Disease ResearchNews Publication Date: January 10, 2025Web References: UK Biobank Official WebsiteReferences: Nature, UK Biobank ArchivesImage Credits: UK Biobank Resources
Keywords: Proteomics, Disease Research, Public Health, Biomarkers, AI in Healthcare, Protein Analysis, Chronic Disease, Personalized Medicine, Machine Learning, Health Monitoring, Aging, Biopharmaceutical Collaboration
A robot developed by Chinese robotics company Unitree shakes hands with an attendee at the Consumer Electronics Show in Las Vegas in the United States on Wednesday. The world’s premier tech show opened on Tuesday and will run through Friday. ABBIE PARR/AP
Chinese technology companies are in the spotlight at the 2025 Consumer Electronics Show, the world’s premier tech show, in Las Vegas in the United States, as they showcase their latest technological achievements and innovative products, including semiconductor displays, smart homes, wearable devices and robots.
Nearly 1,500 Chinese enterprises are participating in the event, which runs from Tuesday to Friday, accounting for more than 30 percent of the total registered exhibitors.
Experts said that this robust participation highlights Chinese companies’ growing strengths and independent innovation capabilities in cutting-edge technologies and emerging fields.
They added that the presence of Chinese companies at CES demonstrates that they are not only playing an increasingly vital role in spearheading the revolution in the global consumer electronics industry, but are also striving to expand their presence in overseas markets despite the US crackdown and sanctions on China’s high-tech sector.
Artificial intelligence-powered terminal devices have attracted attention during this year’s event.
Chinese display panel manufacturer BOE Technology Group launched an array of new technologies and products, including a 31.6-inch slidable organic light-emitting diode display, a vehicle-mounted screen with foldable and curved functions, and an AI-powered smart cockpit.
Liu Zhiqiang, senior vice-president and chief technology officer of BOE, said the application of AI technology in display products will make the devices more intelligent and suitable to more usage scenarios, adding that the company will continue to invest in AI.
Chinese consumer electronics maker TCL showcased a diverse range of innovative gadgets, such as QD-Mini LED TVs, mobile phones, tablets, smart projectors and augmented reality glasses, as well as AI-enabled companion robots.
“The true value of AI lies in its application,” said Li Dongsheng, founder and chairman of TCL Technology Group, emphasizing that the company will focus on building core AI capacities, making technological breakthroughs and expanding its global footprint.
He estimated that the company’s revenue in North America will see 30 percent year-on-year growth in 2025.
A China-made “Land Aircraft Carrier” has attracted lots of attention. The vehicle, from Chinese electric vehicle maker Xpeng Motors’ flying car unit Xpeng Aeroht, made its international debut at CES 2025.
With over 3,000 orders secured, the flying car is positioned to become the world’s first mass-produced vehicle of its kind, with deliveries slated for 2026.
Zhu Keli, founding director of the China Institute of New Economy, said the strong participation of Chinese enterprises at CES 2025 is a testament to China’s increasing technological prowess and competitiveness on the global stage.
“As the world’s biggest consumer electronics show, CES provides a valuable platform for Chinese enterprises to showcase their latest breakthroughs in world-leading technologies and make forays into the international market,” Zhu said.
Zhu added that through participation in the exhibition, these companies can learn about the latest industry trends and market demand, enhance brand awareness and influence, better integrate into global industrial and supply chains, and take part in global governance in the tech domain.
Chinese home appliance manufacturer Hisense unveiled a 116-inch Mini LED TV equipped with its self-developed AI image chips, which will achieve mass production in March.
Augmented reality goggles and robots have gained a strong foothold during the show. Chinese AR company Xreal displayed its latest AR-powered glasses with enhanced entertainment and gaming AR capabilities, while Dreame Technology presented its robotic vacuum cleaners and window-cleaning robots.
Robotics technology company Segway-Ninebot showcased more than 20 products including smart robotic mowers, electric scooters and e-bikes. The company said it hopes to gain insights from global users and expand its presence in the global market via CES.
Chinese companies are diversifying their overseas strategies, with product portfolios expanding from traditional PCs, smartphones and tablets to emerging AI-powered intelligent terminal devices, such as AR glasses, robot vacuum cleaners and smart home equipment, which will become a new growth driver for the consumer electronics industry, said Wang Jiping, vice-president of market research company IDC China.
Wang noted that domestic enterprises are constantly upgrading their products and technologies in an attempt to satisfy the increasingly diversified needs of global consumers and gain a bigger slice of the midrange to high-end overseas market.
Hong Yong, an associate researcher at the Chinese Academy of International Trade and Economic Cooperation, said Chinese companies are at the global forefront of technological innovation, and have made remarkable progress in tech frontiers, such as AI, AR and robotics. The move will be conducive to driving the transformation from “Made in China” to “Created in China”, he added.
NORTH PLATTE, Neb. (KNOP) – The North Platte Public Schools Foundation and Fat Dogs’ Reaching One Classroom at a Time REACH Grant was awarded to an entire elementary school on Monday.Kim Flanders, principal of McDonald Elementary in North Platte, said this year, the book is called “The One and Only Ivan” by Katherine Applegate.“We are super excited to partner, once again, with the North Platte Public Schools Foundation and Fat Dogs. Because of their generosity, we are able to fund a One School, One Book program and we’re going to get books in the hands of all of our McDonald families,” Flanders said.Flanders is using the grant to take part in the One School, One Book program for a second year.“The One school, One Book program is a nationwide program and it encourages schools to select books that appeal to a wide variety of ages and we felt like this book does just that. It kind of helps instill that love for reading and helps families forma a good home to school connection,” Flanders said.McDonald Elementary chose this year’s book based on the kinds of characters it features.“This year we decided to do a different style of book, something with animals. We always know that students love animals,” Flanders said.Click here to subscribe to our KNOP News 2 daily digest and breaking news alerts delivered straight to your email inbox.Copyright 2025 KNOP. All rights reserved.
WASHINGTON — President Joe Biden said wildfires ravaging Los Angeles show climate change is real, days before President-elect Donald Trump is to take office. Trump has threatened to pull back on U.S. efforts to combat global warming. “Climate change is real. … There is global warming, it’s real,” Biden told a crisis meeting at the…
The Lewes Public Library and Browseabout Books will host author Meryl Gordon for a discussion and signing of her new biography, “The Woman Who Knew Everyone: The Power of Perle Mesta, Washington’s Most Famous Hostess,” at 5 p.m., Tuesday, Jan. 21, at the library, 111 Adams Ave., Lewes. The event also will stream live online via Zoom.In her heyday, socialite, political hostess, activist and United States envoy to Luxembourg Perle Mesta was one of the most famous women in America, garnering as much media attention as Eleanor Roosevelt. Gordon’s deeply researched biography chronicles Mesta’s lavish life and society adventures along the East Coast as a wealthy, globe-trotting widow, as well as her important, but nearly forgotten, contributions to American politics and the feminist movement.
The event is free, and registration is required. To sign up, go to tinyurl.com/LPLAuthorEvents or call 302-645-2733. At registration, participants will be asked to select in-person or online attendance.
Gordon is the author of “Mrs. Astor Regrets: The Hidden Betrayals of a Family Beyond Reproach,” “Bunny Mellon: The Life of an American Style Legend,” and “The Phantom of Fifth Avenue.” An award-winning journalist, she is a tenured journalism professor at New York University. Her work has appeared in Vanity Fair, New York Magazine and The New York Times.
A Prayer Book of Days: Praying with the Saints through the Ages by Gregory K. Cameron (Canterbury Press, £12.99 (£11.69); 978-1-78622-595-5).
“Popular author and illustrator Gregory Cameron offers 31 daily prayers from the treasury of Christian spirituality through the centuries. The prayers included some from some giants of the faith — St Augustine, Patrick, St Benedict, Julian of Norwich, Francis of Assisi, Clare — and also lesser known figures right up to recent times who nevertheless left a legacy of prayer that continues to nourish faith and practice today.” Queering the Pulpit: A sexegetical approach to preaching an inclusive word by Karyn L. Wiseman (Cascade Books, £15 (£13.50); 978-1-6667-8198-4).
“Queering the Pulpit addresses the huge gap between the Queer community and the church by looking at the historical, cultural, theological, and biblical issues that too often marginalize the Queer community.” Psalms in an Age of Distraction: Experiencing the restorative power of Biblical poetry by Ethan C. Jones (Baker, £19.99 (£17.99); 978-1-5409-6764-0).
“This book argues that the psalms are poetry for the soul, poetry that shapes us. Beyond highlighting the poetry of the Psalter, the book attends to the theological freight of these poems. As such, we learn to read Scripture more attentively and love God and the world well.”
Selected by Frank Nugent, of the Church House Bookshop, which operates the Church Times Bookshop.
THE book Conversations in Global Anglican Theology joins Anglican Theology: Postcolonial perspectives, edited by Stephen Burns and James Tengatenga (SCM Press, 2024) (Books, 8 November 2024), and has very similar strengths, quirks, and tensions.
To start with strengths: this collection, too, has a well-established editor, who includes articles from a rich mixture of largely non-Western Anglicans. The American Professor Michael Battle has already written several books on Archbishop Tutu’s theology, including Desmond Tutu: A spiritual biography of South Africa’s confessor (WJK, 2021).
The Bishop of Dover, Rose Hudson-Wilkin, and the Archbishop of Cape Town, Thabo Makgoba, both contribute, as do Stephen Spencer, Simon Ro Chul Lai, Thandi Gamedze, Thokozile J. Mbaya, and, most fascinating of all, Wilhelm Verwoerd, a repentant grandson of the architect of apartheid. Rowan Williams’s foreword recognises frankly “the destructive legacy of a Western-dominated pattern of mission activity” — its collusion with the slave trade, its “unexamined power”, and its disastrous indigenous residential schools.
He also observes, shrewdly, that “countless non-European communities [also] found in Christian faith a vision of the world that equipped them to challenge not only the problematic aspects of their own heritage but the evils of colonial power itself.” This, at best, is what these articles seek to do.
Tensions and quirks, however, soon become evident. The usually eirenic Battle admits that Hudson-Wilkin’s article is “sermonic”. Makgoba is somewhat less so and does emphasise the need for a “black theology”, albeit viewed chiefly through the already familiar and influential concept of ubuntu. Perhaps both bishops might be better depicted as significant religious activists rather than theologians — especially since other articles show ubuntu to be a concept not unique, or always germane, to “black theology”.
Lai points out that mutual interdependence can be found readily in the late Orthodox Bishop John Zizioulas’s concept of “being in communion”. Mbaya argues that ubuntu was not in evidence in Makgoba’s traditionalist stance on same-sex marriage, which marginalised Tutu’s ordained daughter. In contrast, Verwoerd, with regard to his own late grandfather, praises Tutu’s pastoral ubuntu, which the former Archbishop championed and embodied when too many others did not.
Spencer does not resolve these tensions in his scholarly historical account of how bishops since the first Lambeth Conference have attempted to reconcile their obvious differences on social or ethical issues. Worryingly, though, Gamedze’s article, based on her research on South African Pentecostal churches, insists at the outset that “race cannot be ignored,” despite acknowledging that “race” is a social construct. Generalising about “White institutional space”, she even shortens this to the pejorative acronym “WIS” and fails to see that this mirrors apartheid ideology.
Quirks apart, this is the first volume of what promises to be (with greater rigorous analysis, please) a worthwhile and timely series.Canon Robin Gill is Emeritus Professor of Applied Theology at the University of Kent and Editor of Theology.
Conversations in Global Anglican TheologyMichael Battle, editorSeabury £21.99(978-1-64065-742-7)Church Times Bookshop £19.79
