Monthly Archives: January 2025

Scientists Uncover Key Step in How Diazotrophs “Fix” Nitrogen

Article Content

Nitrogen is an essential component in the production of amino acids and nucleic acids — both necessary for cell growth and function. Although the atmosphere is composed of nearly 80% nitrogen, this nitrogen is in the form of dinitrogen (N2), which cannot be processed by most organisms. Atmospheric nitrogen must first be converted, or “fixed,” into a form that can be used by plants, often as ammonia.

There are only two ways of fixing nitrogen, one industrial and one biological. To better understand a key component of the biological process, University of California San Diego Professor of Chemistry and Biochemistry Akif Tezcan and Assistant Professor of Chemistry and Biochemistry Mark Herzik took a multi-pronged approach. Their work appears in Nature.

Thriving in a hostile environment

The industrial method is through the Haber-Bosch process, the advent of which in the early 20th century enabled the large-scale production of synthetic fertilizers, increased agricultural yields and helped the world population skyrocket. However, this process is energy-intensive, operating at very high temperatures and pressures. It also requires vast amounts of hydrogen, generated by burning fossil fuels, and is responsible for immense amounts of greenhouse gas emissions.

The biological route to fixing nitrogen is done by diazotrophs, nitrogen-fixing bacteria that contain an enzyme called nitrogenase. In contrast to the Haber-Bosch process, nitrogenase can be catalyzed at ambient pressures and temperatures and does not cause greenhouse gas emissions.

However, nitrogenase also requires large amounts of biochemical fuel, in the form of energy-producing adenosine triphosphate (ATP). Most diazotrophs make large amounts of ATP through cellular respiration by “burning” oxygen — even though nitrogenase is extremely sensitive to oxygen. Scientists have long wondered how a diazotroph, which needs to produce ATP by burning oxygen, also protects nitrogenase from being damaged by oxygen.

Diazotrophs have safety mechanisms in place; however, even with these protections in place, some oxygen penetration into the nitrogen-fixing cell is unavoidable. When this occurs, some diazotrophs employ a “method of last resort” to protect nitrogenase from destruction, called the conformational protection mechanism.

Here an iron-sulfur protein named FeSII senses increasing amounts of oxygen in the cell and binds to the nitrogenase enzyme complex, protecting it from damage and halting ammonia production. When the oxygen levels in the cell decrease, FeSII senses this again, disengages from the nitrogenase, and the ammonia production resumes.

Although scientists have long-known of the FeSII protein, the mechanism by which it protected nitrogenase from oxygen damage was not understood. To answer these questions, the researchers employed several techniques, which together provided detailed insight into how this mechanism worked.

 

The science behind chronic pain: a new receptor could revolutionise treatments

Chronic pain is a condition that affects millions of people worldwide, and its management has been a significant challenge for medicine. As research progresses, important discoveries have been made that could change the way we understand and treat this complex condition. One of these recent advances is the identification of a new receptor that could revolutionize treatments for chronic pain.
The new receiver: a promising breakthroughMolly Qerim unveils her stunning transformation and the secret behind itRecently, researchers have identified a new receptor called neurotensin receptor 1 (NTS1), which appears to play a crucial role in pain modulation. This receptor is found in sensory neurons and is involved in the transmission of pain signals to the brain. Some of the implications it would have are:Pain modulation: Activation of NTS1 could help regulate the intensity of pain signals. This means that if a drug can be developed to act on this receptor, it could offer a new way to relieve chronic pain.Fewer side effects: Many current treatments for chronic pain, such as opioids, have significant side effects and potential for abuse. An NTS1-based approach could provide safer and more effective options.Personalization of treatment: Understanding how this receptor works could also allow for more personalized treatments for different types of chronic pain.Future implicationsThe identification of NTS1 opens new avenues for drug research and development. Scientists are working to create compounds that can activate or block this receptor in order to find effective ways to treat pain without the risks associated with traditional treatments.Moreover, this discovery underscores the importance of continuing to investigate the biological mechanisms behind pain. Each advance brings us closer to a better understanding of how our bodies work and how we can effectively intervene when something goes wrong.

From pineapples to AI: BT Young Scientist projects wow on first day of competition

Opening the 60th BT Young Scientist and Technology Exhibition at the RDS, President Michael D Higgins emphasised the importance of using science for good and not for the development of technology such as weapons
Ryan Foley (14), from De la Salle College in Dublin, explained that his project “Dyslexia Learning AI” uses artificial intelligence to support classroom learning and aids students with preparation for exams.The second-year student said: “I wanted to make an AI app that could help kids with dyslexia by utilising their learning styles. People with dyslexia learn in different ways. So, for example, different colours can impact how they read things, or the use of text-to-speech can help them understand concepts better.”Several of Ryan’s friends have already used the program to study for in-class exams. It allows users to play around with the background colour of inputted text to help find which one works the best for them.A text-to-speech facility uses human voices to read out text inputted into the program. The most popular features are the “rephrase” and “simplify” options to alter text.Ryan’s maths teacher Ms Kelly said these facilities could be of great support to the dyslexic students she teaches.“It can break large portions of text to help them better understand questions making learning much more accessible,” she said.Ryan was quick to emphasise that he did not want the program to simply do the work for students.“I wanted to create something that helps you understand the problem rather than just solving it. It will walk you through how to answer the question rather than handing it to you,” he said.Klara Piechocka (16), from St Columba’s Comprehensive School in Donegal, showcased her project, called Harnessing Donegal’s Coastal Wealth.As part of the project, Klara harvested seaweed on beaches in her locality and explored methods of oil extraction from the seaweed for the production of biodiesel.“I have always visited beaches at home with my friends or family,” she said.“Each time I go I see the mounds and mounds of seaweed that build up and eventually rot on the shore. It is a completely under-utilised resource and I wanted to see if I could make a change through this project.”The transition-year student researched the increase in biodiesel production using various crops in Brazil before experimenting with seaweed.“Soya beans and other crops need arable land or freshwater to grow, in comparison to seaweed – it grows in the ocean and is easy to harvest,” Klara said.The student used steam and hexane distillation to extract oils from the seaweed. To produce biofuel, she added methanol and a catalyst to the oil extracted from the seaweed.“Donegal is a key area due to its extensive coastline and favourable conditions for seaweed growth,” she said.“It hosts 60pc of Ireland’s seaweed growth in comparison to 10pc of growth in Kerry and 20pc in Galway.”Michaela Gillooly’s project, Own your Cycle, Own Your Game, investigated the negative stigma around females speaking about their periods and the impact their menstrual cycle has on their athletic performance. The 18-year-old student got the inspiration for the project because she is a rugby player with Craig RFC in Galway.While tracking her period on the Flo app, she noticed that on the days she had her period she underperformed during a match or training.Michaela is also an under-age rugby coach and saw first-hand how embarrassed the girls she coaches were when talking about their periods.“They would approach me and tell me they were feeling unwell and would ask could I let other coaches know rather than them letting the coaches know themselves,” Michaela said.For her study, she organised two sets of fitness tests. Her first test was on female students in her school and her conclusion was periods were having a negative impact on their performance. Her second test was on a ladies’ Gaelic football (LGFA) team, which returned similar results.“I sent the results back to the LGFA team and it was clear some of the players weren’t as strong on their periods,” she said.“They could then make dietary changes such as including more calcium and iron in their diet before a match.”The initial project won the best project award at the SciFest regional competition in TUS Athlone.For her project, Starry Nights or Missed Delights?, Michelle Hughes (17) of Our Lady’s Bower, Athlone, produced two illustrated books targeting young children to foster an interest in astronomy. “There is a lack of knowledge and interest in viewing astronomical events. Targeting younger kids can help this,” Michelle said.Cathal Fitzgerald (16) and Donnacha Hartnett (15), from Mercy Secondary School Mounthawk in Tralee, Co Kerry, investigated how to use “Pineapple Power” to assist in accelerated burn recovery.“We saw online that the properties of pineapples had great potential and it went from there,” Cathal said.“We are hoping to work on this project into the future and see where it goes.”Opening the exhibition at the RDS yesterday, President Michael D Higgins emphasised the importance of using science for good and not for the development of weapons.“It is both an exciting and a morally challenging time to be a young scientist. Young scientists and technologists have a great responsibility and opportunities to be conscientious and conscious as to where their work will be applied,” he said.“What encourages me to hope is that I see gathered here not only brilliant young scientists, technologists, full of innovative ideas and creativity, but also enthusiastic global citizens, all of which bodes well for their giving support and leadership in the achieving of a sustainable and cohesive future on our island and a harmonious existence on this, our vulnerable planet.“May I encourage you all to help each other with patience and kindness in your work, and to co-operate in advancing the truly emancipatory potential of science for society and for all of life. May your participation in the BT Young Scientist & Technology Exhibition further drive your interest and determination to continue to play a role in science, its application, and its delivery for the betterment of all across the world.”BT Ireland has sponsored the exhibition for 25 years, and its managing director, Shay Walsh, said: “Ireland has generated some of the world’s most exceptional Stem talent in the last 60 decades, with many exhibition alumni going on to change the world for the better. We are immensely proud to have played a role in this during in the last 25 years and look forward to seeing many of this year’s finalists continue to blaze a trail in the sector in years to come.”

What are macros? An exercise and nutrition scientist explains

“I’m tracking my macros.”

“I’ll pass on that, it doesn’t fit in my macros.”

“I’m on the Macro Diet.”

Macros seem to come up often in the corners of the internet and social media devoted to people trying to lose weight, improve their health, look better, and feel better about themselves. But what the heck is a macro?

With more information than ever available at your fingertips, and more diets out there than you have fingers and toes to count on, it’s no wonder you might be confused. As an exercise science specialist interested in physical health and nutrition, I’ve got you covered.

“Macros” is just a shorthand term for macronutrients: protein, carbohydrates, and fats. They’re the nutritional building blocks that all foods are made up of in various ratios.

Nutrition labels let consumers know about the macros and other nutrients in packaged foods. Jaidan899/Wikimedia Commons, CC BY-SA

If you look at a nutrition label, you’ll see that macros are measured in grams. But it’s important to understand that the calories per gram for each macro aren’t the same. Protein and carbohydrates each have 4 calories per gram, while fat has 9 calories per gram. In other words, fat provides more than twice the amount of energy per gram compared with protein and carbohydrates.

People rarely eat proteins, carbohydrates, or fats in isolation. For example, while chicken is widely considered a source of protein, it also contains fat. Almost every food contains more than one macronutrient.

What macros do and where to find them

Beyond its job building muscle, protein also plays other critical roles in the body: as a component of enzymes, transporting nutrients, and producing hormones. Sources of protein include animal meats, eggs, fish and seafood, and dairy. While animal sources have the highest protein content, plant food sources, such as whole grains, legumes such as beans, and nuts, and seeds also contain protein. You don’t need to consume animal products to get adequate protein in your diet.

The 2020-2025 federal dietary guidelines for Americans recommend at least 46 grams of protein for adult females and at least 56 grams for adult males, although this may be too low for older adults, pregnant and lactating women, and people with high levels of physical activity.

Carbohydrates are the body’s preferred energy source. They’re found in bread, rice, pasta, fruits, dairy products, legumes and starchy vegetables. Simple sugars also fit into the carbohydrate category, and those are the ones to limit.

As for fats, there are different types: polyunsaturated, monounsaturated, saturated, and trans fat. Polyunsaturated and monounsaturated have the greatest health benefits and are found in things such as nuts and seeds and fish. Omega-3s are essential fatty acids that can reduce the risk of cardiovascular disease and are found in fatty fish such as salmon and nuts such as walnuts.

Artificial trans fats are created by an industrial process. You’ll see them listed as partially hydrogenated oils on nutrition labels for fried and baked goods. They increase the risk of heart disease and death.

Do calories matter?

In a word, yes, calories matter. But calories from different sources do affect the body differently.

For example, 2,000 calories of junk food and soda are not going to help with appetite control the same way that 2,000 calories of fruits and vegetables, whole grains, healthy fats and lean proteins will. Fiber, for example, is found in fruits, vegetables and whole grains and has been found to be a potent appetite regulator.

The good news is that the most important thing for weight management is caloric balance and consistency. In fact, evidence suggests that there is no “optimal” diet that can be applied to everyone, and that various weight loss strategies – different macronutrient distributions, intermittent fasting and so on – all balance out over the long run.

If you’re attracted to a dietary approach that relies on tracking your macros, focus on getting a healthy balance of protein, carbs and fat. – Rappler.com

Most whole foods contain more than one kind of macro.
carlosgaw/E+ via Getty Images

Tyler Garner, University of Texas at Arlington

“I’m tracking my macros.”

“I’ll pass on that, it doesn’t fit in my macros.”

“I’m on the Macro Diet.”

Macros seem to come up often in the corners of the internet and social media devoted to people trying to lose weight, improve their health, look better and feel better about themselves. But what the heck is a macro?

With more information than ever available at your fingertips, and more diets out there than you have fingers and toes to count on, it’s no wonder you might be confused. As an exercise science specialist interested in physical health and nutrition, I’ve got you covered.

“Macros” is just a shorthand term for macronutrients: protein, carbohydrates and fats. They’re the nutritional building blocks that all foods are made up of in various ratios.

Nutrition labels let consumers know about the macros and other nutrients in packaged foods.
Jaidan899/Wikimedia Commons, CC BY-SA

If you look at a nutrition label, you’ll see that macros are measured in grams. But it’s important to understand that the calories per gram for each macro aren’t the same. Protein and carbohydrates each have 4 calories per gram, while fat has 9 calories per gram. In other words, fat provides more than twice the amount of energy per gram compared with protein and carbohydrates.

People rarely eat proteins, carbohydrates or fats in isolation. For example, while chicken is widely considered a source of protein, it also contains fat. Almost every food contains more than one macronutrient.

What macros do and where to find them

Beyond its job building muscle, protein also plays other critical roles in the body: as a component of enzymes, transporting nutrients and producing hormones. Sources of protein include animal meats, eggs, fish and seafood, and dairy. While animal sources have the highest protein content, plant food sources, such as whole grains, legumes such as beans, and nuts and seeds also contain protein. You don’t need to consume animal products to get adequate protein in your diet.

The 2020-2025 federal dietary guidelines for Americans recommend at least 46 grams of protein for adult females and at least 56 grams for adult males, although this may be too low for older adults, pregnant and lactating women, and people with high levels of physical activity.

Carbohydrates are the body’s preferred energy source. They’re found in bread, rice, pasta, fruits, dairy products, legumes and starchy vegetables. Simple sugars also fit into the carbohydrate category, and those are the ones to limit.

As for fats, there are different types: polyunsaturated, monounsaturated, saturated and trans fat. Polyunsaturated and monounsaturated have the greatest health benefits and are found in things such as nuts and seeds and fish. Omega-3s are essential fatty acids that can reduce the risk of cardiovascular disease and are found in fatty fish such as salmon and nuts such as walnuts.

Artificial trans fats are created by an industrial process. You’ll see them listed as partially hydrogenated oils on nutrition labels for fried and baked goods. They increase the risk of heart disease and death.

Modern nutrition advice focuses on balance.
miodrag ignjatovic/E+ via Getty Images

Do calories matter?

In a word, yes, calories matter. But calories from different sources do affect the body differently.

For example, 2,000 calories of junk food and soda are not going to help with appetite control the same way that 2,000 calories of fruits and vegetables, whole grains, healthy fats and lean proteins will. Fiber, for example, is found in fruits, vegetables and whole grains and has been found to be a potent appetite regulator.

The good news is that the most important thing for weight management is caloric balance and consistency. In fact, evidence suggests that there is no “optimal” diet that can be applied to everyone, and that various weight loss strategies – different macronutrient distributions, intermittent fasting and so on – all balance out over the long run.

If you’re attracted to a dietary approach that relies on tracking your macros, focus on getting a healthy balance of protein, carbs and fat.

Tyler Garner, Clinical Assistant Professor of Kinesiology, University of Texas at Arlington

This article is republished from The Conversation under a Creative Commons license. Read the original article.

King Faisal Prize Laureates in Medicine & Science Receive $400,000 For their Breakthrough Discoveries in Cellular Engineering and Nanotechnology

This section is Partnership Content suppliedThe content in this section is supplied by GlobeNewswire for the purposes of distributing press releases on behalf of its clients. Postmedia has not reviewed the content. by GlobeNewswire Breadcrumb Trail LinksGlobeNewswireAuthor of the article:GlobeNewswirePublished Jan 08, 2025  •  7 minute readKing Faisal Prize for Medicine Laurent for 2025 GNWArticle contentProfessor Michel Sadelain and Professor Sumio Iijima, among other eminent figures, were selected to win the 47th session of the PrizeArticle contentArticle contentSaudi Arabia, Riyadh, Jan. 08, 2025 (GLOBE NEWSWIRE) — January 8, 2025On Wednesday, January 8th, Professor Michel Sadelain, of Canadian origins, was announced the 2025 laureate for King Faisal Prize in Medicine for his groundbreaking contributions to Chimeric Antigen Receptor (CAR) T-cell therapy, a revolutionary cancer treatment that has transformed immunotherapy and inspired advancements in regenerative medicine. Professor Sumio Iijima, from Japan, was named the 2025 laureate for King Faisal Prize in Science in the field of physics for his pioneering discovery of carbon nanotubes, which has redefined nanotechnology and enabled innovations across materials science, electronics, and medicine. In addition, the 2025 King Faisal Prize honored remarkable individuals in the field of Islamic Studies. These laureates were celebrated for their exceptional scholarly contributions, innovative research, and enduring impact on enriching cultural and intellectual heritage, further advancing humanity’s understanding and appreciation of these fields.Advertisement 2Story continues belowThis advertisement has not loaded yet, but your article continues below.THIS CONTENT IS RESERVED FOR SUBSCRIBERS ONLYSubscribe now to read the latest news in your city and across Canada.Exclusive articles from Barbara Shecter, Joe O’Connor, Gabriel Friedman, and others.Daily content from Financial Times, the world’s leading global business publication.Unlimited online access to read articles from Financial Post, National Post and 15 news sites across Canada with one account.National Post ePaper, an electronic replica of the print edition to view on any device, share and comment on.Daily puzzles, including the New York Times Crossword.SUBSCRIBE TO UNLOCK MORE ARTICLESSubscribe now to read the latest news in your city and across Canada.Exclusive articles from Barbara Shecter, Joe O’Connor, Gabriel Friedman and others.Daily content from Financial Times, the world’s leading global business publication.Unlimited online access to read articles from Financial Post, National Post and 15 news sites across Canada with one account.National Post ePaper, an electronic replica of the print edition to view on any device, share and comment on.Daily puzzles, including the New York Times Crossword.REGISTER / SIGN IN TO UNLOCK MORE ARTICLESCreate an account or sign in to continue with your reading experience.Access articles from across Canada with one account.Share your thoughts and join the conversation in the comments.Enjoy additional articles per month.Get email updates from your favourite authors.THIS ARTICLE IS FREE TO READ REGISTER TO UNLOCK.Create an account or sign in to continue with your reading experience.Access articles from across Canada with one accountShare your thoughts and join the conversation in the commentsEnjoy additional articles per monthGet email updates from your favourite authorsSign In or Create an AccountorArticle contentMedicine Prize in “Cellular Therapy” and the Early Research and Development of CAR T-Cell Therapy by Professor Michel SadelainProfessor Sadelain’s research into CAR T-cell therapy began in the early 1990s, driven by his vision to engineer the immune system to precisely target cancer cells. CAR T cell therapy is a type of cellular immunotherapy that aims to transform T cells, which are immune system cells that have a role in the body’s fight against diseases, to enable them to particularly recognize and attack cancer cells in patients with cancer. By 1992, his foundational work introduced the concept of genetically modifying T lymphocytes to express Chimeric Antigen Receptors (CARs). Building on early theories, Professor Sadelain’s team created the first functional CAR T cells in 2002. These cells, capable of recognizing and attacking cancer-specific antigens, became a cornerstone of immuno-oncology. The innovation concluded in the second-generation CARs, which incorporated costimulatory domains like CD28 and 4-1BB. These enhancements not only amplified T-cell activation and persistence but also improved their efficacy in eradicating tumor cells. By 2003, these landmark studies provided conclusive evidence that CAR T cells could eliminate CD19-positive leukemias and lymphomas in animal models, demonstrating the potential of this therapy to achieve complete remission in hematologic cancers and offering curative possibilities for patients with refractory malignancies.Advertisement 3Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentThis discovery translated into the clinical application of CAR T-cell therapy. The U.S. Food and Drug Administration approved the therapy in 2017 for treating Acute Lymphoblastic Leukemia (ALL) and Diffuse Large B-cell Lymphoma (DLBCL). This marked a breakthrough in cancer therapy.Leadership and RecognitionAs the founding director of the Center for Cell Engineering at Memorial Sloan Kettering Cancer Center, Professor Sadelain has fostered a dynamic and collaborative environment that seamlessly integrates science and medicine. His leadership has been instrumental in bridging the gap between fundamental research and clinical application, driving innovations that directly improve patient care. In 2024, Prof. Sadelain was appointed the inaugural director of the Columbia Initiative for Cell Engineering and Therapy, further solidifying his position as a trailblazer in the field. In this role, he continues to lead groundbreaking research aimed at advancing cellular therapies and translating them into life-saving treatments.With over 280 peer-reviewed papers, Prof. Sadelain’s pioneering research has also resulted in the creation of more than 60 patents, underscoring his significant contributions to the field of gene and cell therapy. His influence extended beyond research, having served on the NIH Recombinant DNA Advisory Committee and as President of the American Society for Gene and Cell Therapy. He is also an elected Fellow of the American Association of Cancer Research, a testament to his enduring impact on oncology and immunology.Top StoriesGet the latest headlines, breaking news and columns.By signing up you consent to receive the above newsletter from Postmedia Network Inc.Thanks for signing up!A welcome email is on its way. If you don’t see it, please check your junk folder.The next issue of Top Stories will soon be in your inbox.We encountered an issue signing you up. Please try againArticle contentAdvertisement 4Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentProfessor Sadelain’s groundbreaking work has earned him numerous prestigious honors, including the Cancer Research Institute’s Coley Award for Distinguished Research in Tumor Immunology, the Sultan Bin Khalifa International Award for Innovative Medical Research on Thalassemia, and the NYIPLA Inventor of the Year award. Among his many honors are the Passano Award, the Pasteur-Weizmann Award, the Gabbay Award, the INSERM International Prize Laureate, and the ARC Foundation Léopold Griffuel Award. Additionally, he has been recognized with the Outstanding Achievement Award from the American Society for Gene and Cell Therapy and the Clarivate Citation Laureate in Physiology or Medicine. In 2024, Dr. Sadelain was awarded the prestigious Breakthrough Prize in Life Sciences and the Canada Gairdner Award, further cementing his legacy as a transformative figure in cellular therapy and medicine.Science Prize in the field of “Physics” and The Discovery of Carbon Nanotubes by Professor Sumio IijimaProf. Sumio Iijima revolutionized materials science and nanotechnology with his discovery of carbon nanotubes (CNTs) in 1991. These cylindrical structures, composed of graphene—a single layer of carbon atoms arranged in a hexagonal lattice—exhibit extraordinary mechanical, electrical, and thermal properties, making them one of the most studied nanomaterials in modern science. Prof. Ijima’s seminal work, published in Nature, detailed the observation of multi-walled carbon nanotubes (MWCNTs) using high-resolution transmission electron microscopy (HRTEM). These tubular structures, consisting of concentric graphene cylinders, possess diameters ranging from a few nanometers to tens of nanometers. Two years later, Iijima and his collaborators identified single-walled carbon nanotubes (SWCNTs), which consist of a single graphene cylinder with a diameter as small as one nanometer. This marked a significant breakthrough, as SWCNTs exhibit unique quantum mechanical properties due to their reduced dimensionality.Advertisement 5Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentThe discovery of CNTs has catalyzed advancements in numerous fields. In the realm of energy, CNTs are being developed for high-capacity lithium-ion batteries, supercapacitors, and hydrogen storage systems due to their large surface area and conductive properties. In medicine, CNTs are studied for their potential in targeted drug delivery and bioimaging, where their nanoscale dimensions enable precision targeting of diseased cells. In environmental science, CNT-based membranes are being used for water purification and desalination, offering an efficient and scalable solution to global water shortages. Their ability to adsorb pollutants while maintaining high flow rates exemplifies their potential in addressing critical sustainability challenges.Legacy and RecognitionProf. Iijima is an honorary fellow of the National Institute of Advanced Industrial Science and Technology (AIST) and a member of prestigious academies worldwide, including the U.S. National Academy of Sciences and the Chinese Academy of Sciences. His seminal paper on carbon nanotubes has garnered over 58,000 citations, underlining its monumental influence in scientific literature.Advertisement 6Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentHe gained global recognition and invitations to prestigious international conferences, including the 2014 KAUST-NSF Conference, where his work was celebrated as foundational to nanotechnology research. His contributions were honored with numerous prestigious awards, such as the Franklin Medal in Physics (2001), the Agilent Europhysics Award, the APS McGroddy Prize, the Imperial Prize, and the Japan Academy Prize. In 2009, he received Japan’s Order of Culture Merits, reflecting the national significance of his work.Internationally, his impact was acknowledged with the Aminoff Prize from Sweden and the Balzan Prize from Italy in 2007, and the European Inventor Award in 2015. His influence extends beyond academia into global scientific communities; he was elected as a member of the Japan Academy and honored as a foreign member of the Norwegian Academy of Science and Letters, the U.S. National Academy of Sciences, and the Chinese Academy of Sciences.Honoring Pioneers in Archaeology and Cultural Heritage in  King Faisal PrizeIn addition to Medicine and Science, King Faisal Prize recognized this year the achievements of an outstanding thinker and scholar in the field of Islamic Studies. Professor Said Al-Said and Professor Saad Al-Rashed have been jointly awarded the King Faisal Prize in Islamic Studies for 2025 for their exceptional contributions to archaeology and the preservation of cultural heritage in Saudi Arabia.Advertisement 7Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentProfessor Al-Said, a distinguished Saudi professor at King Saud University, has significantly advanced the understanding of the Arabian Peninsula’s archaeological history. His extensive research includes the publication of 91 scientific papers in multiple languages, focusing on the region’s rich archaeological heritage. Notably, he co-chaired the Saudi-German excavation project in Tayma, uncovering insights into ancient civilizations. Professor Al-Rashed, a pioneering Saudi archaeologist, has dedicated over five decades to unearthing and preserving the hidden treasures of Arabia’s heritage. His groundbreaking studies on Islamic pilgrimage routes, particularly the Darb Zubayda, and early Islamic cities have provided invaluable insights into the region’s historical and civilizational evolution. His work at Al-Rabadha has been pivotal in understanding early Islamic urban planning and culture. King Faisal Prize for Arabic Language & Literature for 2025 on the topic of “Studies of Identity in Arabic Literature” was withheld due to nominated works not elevating to the criteria of the prize.Advertisement 8Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentKing Faisal Prize laureates’ names for 2025 were announced today in Riyadh, Saudi Arabia, by HH Prince Bandar Bin Saud Bin Khalid and the Prize’s Secretary General Dr. Abdulaziz Alsebail. About King Faisal PrizeSince 1979, King Faisal Prize in its 5 different categories has awarded 299 laureates who have made distinguished contributions to different sciences and causes. Each prize laureate is endowed with USD 200 thousand; a 24-carat gold medal weighing 200 grams, and a Certificate inscribed with the Laureate’s name and a summary of their work which qualified them for the prize.AttachmentsMichel Sadelain Sumio IijimaArticle contentShare this article in your social networkComments Join the Conversation Featured Local Savings

Explosive docs reveal finals days of scientist who mysteriously died during CIA mind control program MKUltra

By STACY LIBERATORE FOR DAILYMAIL.COM Published: 12:46 EST, 8 January 2025 | Updated: 13:57 EST, 8 January 2025

Telommer Boost Capsules of Youth Exposed: Are the Claims Backed by Science?

In an age where the quest for longevity and vitality is more prominent than ever, Telommer Boost Capsules of Youth emerge as a beacon of hope for those seeking to enhance their health and well-being. This innovative dietary supplement is designed to combat the effects of aging at a cellular level, harnessing advanced scientific research to support your body in its natural fight against the passage of time. By focusing on boosting cellular health, these capsules aim to prolong life and improve the quality of life, allowing you to enjoy every moment more fully.
Telommer Boost is formulated with potent ingredients that target various aspects of cellular aging, including energy production, cognitive function, and overall vitality. The product is ideal for individuals who are proactive about their health and are looking for effective ways to support their body’s natural processes. Whether you are an athlete seeking faster recovery times, a busy professional aiming for improved mental clarity, or someone who wishes to maintain their youthful energy as they age, Telommer Boost could be the solution you’ve been searching for.
With a commitment to quality and safety, Telommer Boost Capsules are non-GMO, vegan-friendly, and free from common allergens like soy, gluten, and dairy. The capsules are crafted using vegetable cellulose, making them suitable for those with dietary restrictions. By investing in your health with Telommer Boost, you are not just purchasing a supplement but embracing a lifestyle that prioritizes longevity, vitality, and overall well-being. Discover how these capsules can transform your health journey and lead you to a more vibrant life.
What is Telommer Boost Capsules of Youth?

Telommer Boost Capsules of Youth is a dietary supplement designed to support cellular health and combat the effects of aging. The formulation combines well-researched ingredients that synergize to increase energy levels, enhance cognitive function, and promote overall wellness. The capsules serve as a daily ally in your health regime, addressing the underlying cellular processes contributing to aging.
The science behind Telommer Boost revolves around telomeres—protective caps at the ends of chromosomes that shorten as we age. When telomeres become too short, cells can no longer divide, leading to aging and cellular dysfunction. By incorporating ingredients that support telomere health and boost cellular energy, this product aims to slow down the biological clock and enhance your body’s resilience against age-related decline.
Telommer Boost suits anyone looking to improve their health and maintain vitality as they age. Regular use can help mitigate the effects of stress, improve recovery times, and support mental clarity, making it an excellent addition to the routines of active individuals, busy professionals, and anyone committed to a healthier lifestyle.
Ready For Similar Top Anti-Aging Supplements? Click Here!
Does Telommer Boost Work?

The efficacy of Telommer Boost Capsules of Youth lies in its carefully selected ingredients, each backed by scientific research. Users have reported noticeable improvements in energy levels, cognitive function, and overall well-being after consistently using the product. The formulation’s unique blend of compounds works on multiple fronts—supporting mitochondrial function, enhancing antioxidant defenses, and promoting better cellular communication.
Clinical studies have demonstrated the benefits of its key ingredients in improving health markers associated with aging. For instance, Nicotinamide Mononucleotide (NMN) has been shown to elevate NAD+ levels in the body, a critical coenzyme involved in energy metabolism and DNA repair. This increase in NAD+ can enhance cellular function and improve physical performance.
Moreover, ingredients like Ergothioneine and Resveratrol are recognized for their antioxidant properties, helping to combat oxidative stress that accelerates aging. By protecting cells from damage, these compounds support longevity and promote healthier aging.
While users’ experiences may vary, the consensus is that Telommer Boost provides a meaningful boost to health when integrated into a balanced diet and lifestyle. Its ingredients’ combined power and commitment to quality and purity suggests that Telommer Boost is a viable option for those looking to improve their health and slow the aging process.
What are the ingredients in Telommer Boost Capsules of Youth?
450 mg Nicotinamide Mononucleotide (NMN)

Nicotinamide Mononucleotide (NMN) is a naturally occurring compound that plays a vital role in producing Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme essential for cellular metabolism and energy production. As we age, NAD+ levels decline, leading to reduced cellular function and vitality. By supplementing with NMN, individuals can effectively boost their NAD+ levels, which has been linked to improved energy, enhanced cognitive function, and better overall health. Research indicates that NMN supplementation can support mitochondrial function, promote healthy aging, and even improve physical performance. This powerful ingredient is at the forefront of aging research, making it a cornerstone of Telommer Boost.
2 mg Ergothioneine

Ergothioneine is a unique amino acid with potent antioxidant properties, often called the “longevity vitamin.” Found in high concentrations in mushrooms and certain other foods, Ergothioneine helps protect cells from oxidative stress and inflammation, which are key contributors to aging. Its ability to accumulate in various tissues makes it particularly effective in safeguarding cellular health. Studies suggest that Ergothioneine can enhance cognitive function, support cardiovascular health, and improve overall well-being. Telommer Boost provides an extra layer of protection against age-related decline by including Ergothioneine in its formulation.
Shop Top Sellers! Click For Similar Anti-Aging Supplements
50 mg Trans Resveratrol

Trans Resveratrol is a naturally occurring polyphenol found in grapes, berries, and red wine, renowned for its potential anti-aging effects. This powerful antioxidant has been extensively studied for its ability to activate sirtuins, proteins that play a crucial role in regulating cellular health and longevity. Resveratrol has been shown to support cardiovascular health, enhance insulin sensitivity, and protect against age-related diseases. Its inclusion in Telommer Boost not only helps combat oxidative stress but also promotes healthy aging by supporting cellular repair mechanisms and improving metabolic function.
25 mg Olive Fruit Extract (40% Hydroxytyrosol)

Olive fruit extract, particularly the hydroxytyrosol component, is one of the most potent antioxidants. Hydroxytyrosol supports cardiovascular health, reduces inflammation, and protects against oxidative stress, which can lead to chronic diseases and accelerated aging. The extract is also thought to enhance cellular communication and promote healthier cellular function. By incorporating this ingredient into Telommer Boost, the formulation benefits from its profound antioxidant properties, further supporting overall health and longevity.
10 mcg Vitamin D3 (Cholecalciferol)

Vitamin D3, or cholecalciferol, is an essential nutrient critical in bone health, immune function, and overall well-being. The body synthesizes it upon exposure to sunlight, but many people do not receive adequate amounts due to lifestyle and environmental factors. Supplementing with Vitamin D3 can help maintain optimal levels, support various bodily functions and promote healthy aging. Research has linked sufficient Vitamin D levels to improved mood, cognitive function, and reduced risk of chronic diseases. Telommer Boost provides a significant dose of Vitamin D3 to help ensure that users effectively support their overall health.
Find Similar Best Anti-Aging Supplements Today! Click Now
Telommer Boost Benefits
Enhanced Cellular Energy and Metabolism

One of the primary benefits of Telommer Boost Capsules of Youth is the enhancement of cellular energy and metabolism. The combination of NMN and Vitamin D3 plays a critical role in mitochondrial function, which produces energy within cells. As we age, mitochondrial efficiency declines, leading to fatigue and decreased physical performance. By supplementing with Telommer Boost, users can effectively increase NAD+ levels, which in turn fuels the mitochondria and revitalizes energy production.
Increased energy levels can profoundly impact daily life, enabling individuals to engage more actively in physical activities, improve exercise performance, and recover more quickly after strenuous workouts. This boost in energy enhances physical health and supports mental clarity and focus, making it easier to tackle daily tasks and responsibilities.
Furthermore, a well-functioning metabolism is crucial for maintaining a healthy weight and preventing metabolic diseases. By improving metabolic efficiency, Telommer Boost helps support weight management efforts and promotes overall health and vitality.
Improved Cognitive Function

Cognitive decline is a common concern as we age, but Telommer Boost Capsules of Youth can help combat this issue with its potent blend of ingredients designed to support brain health. Ergothioneine and Resveratrol are recognized for their neuroprotective properties, helping shield the brain from oxidative stress and inflammation that contribute to cognitive decline.
Research has demonstrated that increasing NAD+ levels through NMN supplementation can enhance synaptic plasticity, vital for learning and memory. Users of Telommer Boost often report improved mental clarity, sharper focus, and enhanced cognitive performance. By supporting brain health, Telommer Boost improves the quality of life and empowers individuals to stay mentally agile and engaged, regardless of age.
Get Similar Best Anti-Aging Supplements Today! Click Now
Support for Healthy Aging

Telommer Boost Capsules of Youth focuses on supporting healthy aging by targeting the underlying processes that lead to age-related decline. The antioxidants present in the formulation, including Ergothioneine and Hydroxytyrosol, help combat oxidative stress, a significant contributor to the aging process. By protecting cells from damage, these antioxidants promote better cellular health and longevity.
Moreover, the product’s ability to support telomere health through its unique blend of ingredients can play a vital role in slowing down the aging process. Telomeres naturally shorten with each cell division, and cellular aging accelerates when they become too short. By nourishing the body with Telommer Boost, users can support their cells’ ability to maintain telomere length and functionality, ultimately promoting a healthier, more vibrant life.
Immune System Support

A robust immune system is essential for overall health, especially as we age. Telommer Boost Capsules of Youth contribute to immune system support through the inclusion of Vitamin D3, which is known to play a crucial role in immune function. Adequate Vitamin D levels are essential for the proper functioning of immune cells, helping the body defend against infections and diseases.
The antioxidant properties of the ingredients also help bolster the immune system by reducing inflammation and oxidative stress, which can weaken immune responses. Regular use of Telommer Boost can help ensure that your immune system remains strong and resilient, allowing you to enjoy a healthier, more active lifestyle as you age.
Long-Term Health Benefits

Investing in your health with Telommer Boost Capsules of Youth goes beyond immediate benefits; it lays the foundation for long-term wellness. The synergistic effects of NMN, Resveratrol, Ergothioneine, and other ingredients can contribute to a lower risk of age-related diseases, including cardiovascular disease, neurodegenerative disorders, and metabolic issues.
By supporting cellular health, boosting energy levels, and promoting cognitive function, Telommer Boost not only enhances quality of life today but also helps ensure a healthier future. The proactive approach to aging that Telommer Boost promotes is essential for anyone looking to live life to the fullest, regardless of age.
Click For Other Top Anti-Aging Supplements Picks!
What is the price of Telommer Boost?

The pricing for Telommer Boost Capsules of Youth has been structured to offer great value for those seeking to invest in their health. Here is a breakdown of the pricing options available:

Subscribe & Save: $73 per bottle, saving you $15 off the regular price.
One-Time Purchase: $88 per bottle.

The subscription model provides a discount and ensures that you never run out of your essential supplement. This convenient option allows you to receive automatic shipments every month, making it easier to maintain your health regimen without any interruptions.
By choosing Telommer Boost, you’re making a wise investment in your longevity and well-being. With the combination of high-quality ingredients and a commitment to safety and efficacy, this product stands out in a crowded market, making it worth the price for those dedicated to enhancing their health.
Are there side effects to Telommer Boost?

As with any dietary supplement, it’s essential to consider potential side effects. Fortunately, Telommer Boost Capsules of Youth are formulated with high-quality, natural ingredients and are generally well-tolerated by most users. The product is free from common allergens such as soy, gluten, dairy, and fish, making it suitable for various dietary preferences.
Some users may experience mild digestive discomfort when first starting the supplement, which is common with many new dietary products. This can include symptoms such as bloating or gas, but these effects typically subside as the body adjusts to the new ingredients.
It is important to note that individuals with specific health conditions or those taking medications should consult with their healthcare provider before starting any new supplement regimen, including Telommer Boost. This is particularly relevant for pregnant or nursing women, as safety during these periods has not been established.
Overall, Telommer Boost is designed with safety in mind, using non-GMO, vegan-friendly ingredients that prioritize your health. With proper use and consideration, most individuals can enjoy the benefits of this supplement without significant side effects.
Shop Top Sellers! Click For Similar Anti-Aging Supplements
Who makes Telommer Boost?

Telommer Boost Capsules of Youth are produced by a reputable company that prioritizes quality, transparency, and scientific research in their supplement formulations. The brand is committed to providing effective health solutions that are grounded in the latest scientific discoveries related to aging and cellular health.
The team behind Telommer Boost includes scientists and health professionals who work diligently to source high-quality ingredients and ensure the product meets rigorous safety and efficacy standards. Each batch undergoes thorough testing to guarantee purity and potency, allowing consumers to trust that they are getting a premium product.
The company also emphasizes sustainability and ethical practices in its operations. By choosing non-GMO and vegan-friendly ingredients, they align their products with the values of health-conscious consumers who are looking for supplements that reflect their lifestyle choices.
By investing in Telommer Boost, you are supporting a brand that genuinely cares about the health and well-being of its customers, making it a reliable choice in the quest for enhanced longevity and vitality.
Does Telommer Boost Really Work?

The effectiveness of Telommer Boost Capsules of Youth is closely tied to how supplements work in conjunction with diet and exercise. While the powerful ingredients in Telommer Boost can provide significant health benefits, it is essential to recognize that supplements are most effective when used as part of a holistic approach to health.
A balanced diet rich in whole foods, fruits, vegetables, healthy fats, and lean proteins provides the essential nutrients your body needs to function optimally. When combined with the ingredients in Telommer Boost, which are designed to enhance cellular energy and protect against oxidative stress, users can experience even greater benefits.
Regular physical activity is also crucial for maintaining a healthy metabolism, improving cardiovascular health, and supporting mental well-being. Engaging in exercise can amplify the effects of Telommer Boost, helping to enhance endurance, strength, and overall fitness levels.
Furthermore, lifestyle factors such as stress management, adequate sleep, and hydration play vital roles in your overall health. By addressing these areas while taking Telommer Boost, individuals can create a comprehensive wellness plan that maximizes the supplement’s benefits.
In conclusion, Telommer Boost is not a magic solution, but rather a valuable tool that, when combined with a healthy lifestyle, can lead to significant improvements in vitality, energy levels, and overall well-being. The key to success lies in the commitment to a balanced approach that includes proper nutrition, exercise, and self-care.
Explore More Best Anti-Aging Supplements. Click To Shop!
Is Telommer Boost a Scam?

No, Telommer Boost Capsules of Youth are not a scam. This product is backed by scientific research and formulated with high-quality ingredients that have been shown to support cellular health and combat the effects of aging. The company behind Telommer Boost is transparent about its sourcing, manufacturing processes, and ingredient efficacy, allowing consumers to make informed decisions about their health.
Additionally, numerous positive user reviews and testimonials highlight the effectiveness of Telommer Boost in enhancing energy levels, cognitive function, and overall well-being. While individual results may vary, the consensus among users is that the product delivers on its promises, making it a legitimate option for those interested in promoting healthy aging.
Consumers should always do their due diligence when choosing supplements, ensuring they purchase from reputable sources and consult with healthcare professionals if needed. Telommer Boost is available exclusively through its official website, where customers can trust that they are receiving a genuine product that meets the highest standards of quality and safety.
Is Telommer Boost FDA Approved?

While Telommer Boost Capsules of Youth are manufactured in facilities that adhere to Good Manufacturing Practices (GMP), it is essential to understand that dietary supplements do not require FDA approval before being marketed. The FDA does not evaluate the safety or effectiveness of dietary supplements in the same way it does for prescription medications.
However, the company behind Telommer Boost is committed to transparency and quality. The ingredients used in the formulation are backed by scientific research, and the product undergoes rigorous testing to ensure purity and potency. This commitment to quality and safety is crucial for consumers looking for effective health solutions.
It is also important to note that the FDA does have guidelines and regulations in place to ensure that dietary supplements are produced safely and labeled accurately. By adhering to these standards, Telommer Boost provides consumers with a trustworthy product that prioritizes health and well-being.
Discover Similar Top Anti-Aging Supplements Now! Click Here
Where to buy Telommer Boost?

Telommer Boost Capsules of Youth can be purchased exclusively from the official website. This ensures that customers receive the genuine product while benefiting from the company’s commitment to quality and customer service. Buying directly from the source also means you can take advantage of any special offers or discounts available, making it a smart choice for those looking to invest in their health.
The official website provides detailed information about the product, including its ingredients, benefits, and pricing. Additionally, customers can access helpful resources and FAQs to answer any questions they may have. By choosing to buy from the official site, you can rest assured that you are receiving a safe and effective supplement that supports your health and wellness journey.
Is Telommer Boost Really on Amazon, eBay, and Walmart?
Telommer Boost on Amazon

Telommer Boost is not available on Amazon or through any Amazon partners. This decision by the company ensures that the product is handled and stored correctly before reaching consumers. By avoiding third-party platforms, the integrity and safety of Telommer Boost can be guaranteed. For purchase, the only authorized source is the official website, with no plans to offer the product via Amazon.
Telommer Boost on eBay

Telommer Boost is also unavailable for sale on eBay or any affiliated eBay stores. This approach allows the company to maintain complete control over product quality and prevent the risk of contaminated or tampered goods. To ensure safety, it is recommended to purchase Telommer Boost directly from the official website. The company does not endorse or allow sales on eBay.
Telommer Boost on Walmart

You will not find Telommer Boost on Walmart’s shelves or website. While Walmart may carry various natural products, Telommer Boost requires specific storage and handling to preserve its purity and effectiveness. By selling directly, the company minimizes risks to consumers and guarantees the best product quality. Telommer Boost is only available through the official website.
Ready For More Top Anti-Aging Supplements? Click Here!
Conclusion for Telommer Boost

In summary, Telommer Boost Capsules of Youth offer a promising solution for individuals seeking to enhance their health and counteract the effects of aging. With a carefully curated blend of scientifically-backed ingredients, this supplement aims to support cellular energy, cognitive function, and overall well-being. The commitment to quality, safety, and transparency further reinforces the product’s credibility, making it a reliable option for health-conscious consumers.
By integrating Telommer Boost into your daily routine, you can take a proactive approach to your health, investing in your longevity and vitality. The benefits of this supplement extend beyond immediate effects, laying the groundwork for a healthier future and a more vibrant life.
Ultimately, investing in Telommer Boost is not just about purchasing a product but about embracing a lifestyle that prioritizes well-being, resilience, and the joy of living fully. For those ready to embark on this journey towards enhanced health and longevity, Telommer Boost stands as a worthy companion.
Telommer Boost FAQs
What is Telommer Boost?

Telommer Boost is a dietary supplement designed to support cellular health and combat aging through a blend of potent ingredients.
How does Telommer Boost work?

The supplement works by boosting NAD+ levels, enhancing mitochondrial function, and providing antioxidant protection to promote overall health.
What are the key ingredients in Telommer Boost?

Key ingredients include Nicotinamide Mononucleotide (NMN), Ergothioneine, Trans Resveratrol, Olive Fruit Extract, and Vitamin D3.
Find Similar Best Anti-Aging Supplements Today! Click Now
Are there any side effects?

Most users tolerate Telommer Boost well, but some may experience mild digestive discomfort initially.
Where can I buy Telommer Boost?

Telommer Boost is available exclusively through the official website.
Is Telommer Boost FDA approved?

Dietary supplements do not require FDA approval, but Telommer Boost is manufactured in compliance with safety standards.
Does Telommer Boost really work?

Many users report positive effects on energy levels and cognitive function, especially when combined with a healthy lifestyle.
Can I take Telommer Boost with other medications?

It’s best to consult with a healthcare provider before combining any supplements with medications.
Is Telommer Boost available on Amazon or eBay?

No, Telommer Boost is not sold on Amazon or eBay to ensure product integrity and quality.
How much does Telommer Boost cost?

The price is $73 for a subscription (saving $15) or $88 for a one-time purchase.
Get Similar Best Anti-Aging Supplements Today! Click Now