INTERVIEW: Michael Cera Talks ‘Reckless’ Road Trips for New Movie Sacrament

Entertainment gossip and news from Newsweek’s network of contributors”I’ve been on a lot,” says Michael Cera of road trips. One of them ended in his car getting totalled.That’s not the subject of his new movie Sacramento, a warm buddy comedy-drama directed by and co-staring real-life friend Michael Angarano alongside Kristen Stewart, but it certainly provided some requisite travel experience.”Before we had kids we used to drive all over the country,” Cera tells Newsweek. “And I had a Corolla for 15 years until it got totalled one morning. I wasn’t in it. I was parked on the street and I went to go in it, and it had been ripped apart like a can of tuna. I think a garbage truck hit it. I got a good cheque for it. And then we got a Camry.”

Michael Cera is one of the stars of Sacramento
Michael Cera is one of the stars of Sacramento
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Angarano, who plays Cera’s long-time best friend Rickey, had an equally eye-opening road trip. Together with Sacramento co-writer Chris Smith, he drove from LA to Sacramento, and the experience provided some inspiration for the film.”I mean, actually a very key thing that we learned on that trip was that there is a real MMA community in Sacramento. And so that whole little side quest that they go on when they meet these women in Sacramento and they show them their gym, that was born out of that that trip that we actually took. We met people in a bar that told us there was this huge MMA and fighting community in Sacramento.”What is Sacramento About?In Sacramento, the arrival of Rickey (Michael Angarano) kicks off an impromptu road trip for he and best friend Glenn (Michael Cera). Meanwhile his wife Rosie (Kristen Stewart) is preparing their lives for the imminent arrival of a baby.The movie stays true to the Sacramento setting. In fact, many scenes were shot on-location, in public, with the town’s actual residents appearing in the background. This, at times, proved challenging.”Friday night at a bar in public, we’re in there making a movie and hoping they don’t look at us and look at the camera. We’re just trying to be in character, and that was our last day of shooting too. That was sort of like, ‘well, let’s see what we get here.'”

Michael Angarano stars in Sacramento
Michael Angarano stars in Sacramento
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Speaking of challenges, Cera’s cough was another. It was so persistent, it threatened to derail the entire shoot.”So in terms of challenge, I mean, just making movies in general is stressful and I couldn’t eat for the first two weeks, just because I was stressed out and I had such a bad cough,” says Cera. “It was hard to speak at times.”He refused to believe that he had a serious cough,” added Angarano.Cera’s next film is The Running Man, a remake of the 1988 Arnold Schwarzenegger classic action caper. It couldn’t be more different to Sacramento. “I’m only in it a little bit,” Cera says, “but I was shown some of it, and it’s going to be really fun.””It’s kind of just one big action sequence after another, and it’s just pure fun.”

The Multiverse Trend Finally Got The Horror Movie It So Desperately Needs

Mothership Motion Pictures

The phrase “breaking the cycle” typically signifies putting an end to a repetitive pattern of damaging behaviors — whether it be cycles of abuse, addiction, oppression, trauma, or grief. As destructive as the cycle may be, it’s difficult to break out of for reasons that go beyond the systemic forces keeping people trapped within. After all, there’s also an odd sense of familiarity that often paralyzes us from wanting to try something different. Even if it’s bad for us, at least we can predict the outcome and prepare for what it brings. In Kevin and Matthew McManus’ “Redux Redux,” a mother named Irene Kelly (Michaela McManus) has invested in a machine sold on the black market that gives her the ability to jump between parallel universes of our world. Multiverse stories are having a huge moment, but Irene isn’t transporting herself for curiosity’s sake or to defeat an interdimensional villain; she’s looking for a timeline where her murdered daughter is still alive.
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Irene’s daughter was kidnapped and killed by a serial killer named Neville (the always great Jeremy Holm), who usually works as a fry cook but sometimes has other jobs, depending on which multiverse she arrives in. Unfortunately, for the countless times she’s jumped, the result has remained the same: Her daughter is dead, Neville is the one who killed her, and Irene is going to process her grief by enacting her own, cold-blooded revenge on her daughter’s perpetrator. By the time we meet Irene, she’s killed Neville so many times she’s lost count. Her cycle of grief has evolved into a cycle of violence, one she’s unsure she’ll ever be able to break.
The McManus Brothers have mainstream credibility, having produced and written episodes of both “American Vandal” and “Cobra Kai,” but their feature filmography is a fascinating array of styles. Their debut feature “Funeral Kings” is a scrappy, coming-of-age comedy about altar boys who get into hijinks after working at funerals, while “The Block Island Sound” is an aquatic sci-fi thriller that Kalyn Corrigan described in her review for /Film as “a fever dream of a movie.” Now, they’ve delivered their strongest film yet, one that quickly became one of the most talked about flicks at the Overlook Film Festival.
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Redux Redux shows you can’t kill your way through anguish

Mothership Motion Pictures

Unlike all those multiverse stories that display parallel universes as fantastically different (like the one where Loki is an alligator), “Redux Redux” never takes its feet off the ground despite its inherently sci-fi premise. Each new universe is nearly identical to the one visited before, so much so that Irene is able to stockpile keys for getaway trucks, rent vacant hotel rooms, and anticipate Neville’s daily routine. In some universes, he doesn’t get the day off as usual and Irene is forced to kill him in broad daylight at the diner where he works, but these are minor inconveniences compared to the agonizing pain she endures every day as a grieving mother.
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The science behind “Redux Redux” isn’t overcomplicated and requires some serious suspension of disbelief, but the how behind Irene’s journey isn’t nearly as interesting as the why. Take, for example, Irene’s habit of catching an occasional cocktail with the chatty Jonathan (Jim Cummings), a man who is also experiencing grief in every universe but is unaware whenever he meets Irene that this isn’t the first time they’ve crossed paths. Rage is no way to cure yourself of sorrow, but she’s willing to keep trying, even if it kills her.
Irene’s new cycle is only interrupted when she crosses paths in one universe with a young woman named Mia (Stella Marcus in a fantastic debut), a would-be fellow victim of Neville who managed to escape his grasp. She’s feisty and sharp-tongued, providing a needed light-hearted salve from Irene’s painful seriousness. Her intrusion into Irene’s adventure not only prevents “Redux Redux” from feeling, well, repetitive, but her presence also allows us to see a new side of Irene — the woman she was before Neville ruined her life.
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Redux Redux is a refreshing adventure in lo-fi sci-fi horror

Mothership Motion Pictures

There are countless movies about grieving mothers, but we seldom get to see the loving, motherly side of their personalities before tragedy transformed them into Sarah Connor-archetypes. It’s quite touching to see how quickly “mom mode” comes flooding back to Irene, reflexively interjecting conversations with reminders of what Mia should do to take better care of herself. It’s also jarring considering we’ve seen Irene graphically obliterate Neville in countless ways, a reminder that many of our own mothers would slice, dice, stab, shoot, and set on fire anyone who would take us from them.
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By keeping the film in a lo-fi setting, “Redux Redux” feels like a film that would be right at home with the work of Rustic Films, especially last year’s fellow Overlook Film Festival standout, “Things Will Be Different.” In an era when studios are inflating already-obscene budgets in the hopes of building CGI multiverses only for their tentpoles to underperform at the box office (inspiring executives to shrug their shoulders and act as if there was no way to predict that the movie wouldn’t be a hit), “Redux Redux” is a phenomenal reminder that money will never be a match for a great story brought to life with incredible actors. These are the kinds of stories that we should be investing in and the type of creative voices we should be fostering.
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At least we can take solace in knowing that in another parallel universe, we are.

China Will Play Fewer Hollywood Movies Due To Trump Tariffs – And The Box Office Will Suffer

20th Century Studios

What has already been a rough year at the box office (make that a rough handful of years) is about to get even more rough. As we recently reported, U.S. President Donald Trump’s tariffs led China to consider a pause on allowing any Hollywood films to play in the country. Recently, Trump put a 90-day hold on his tariffs throughout much of the world, with the exclusion of China. Instead, he raised the tariffs once again on the country, escalating the trade war between two of the world’s biggest economies. Now, that trade war is officially coming for Hollywood.
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According to a new report from Bloomberg, Chinese regulators are officially going to reduce the number of U.S. films allowed in the country in response to the tariffs imposed by Trump. Just how severe the reduction will be remains to be seen, but China has already been favoring homegrown titles of late, including this year’s “Ne Zha 2” (which made more than $2 billion from Chinese ticket sales alone). The China Film Administration had this to say about it in a statement:

“The wrong action of the US government to abuse tariffs on China will inevitably further reduce the domestic audience’s favorability towards American films. We will follow the market rules, respect the audience’s choice, and moderately reduce the number of American films imported. China is the world’s second-largest film market. We have always adhered to a high level of opening up to the outside world and will introduce more excellent films from the world to meet market demand.”

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While Hollywood movies have been making far less in China since the pandemic, it remains the second-biggest moviegoing market in the world. Plus, certain movies still perform very well there. “Avatar: The Way of Water” made $2.3 billion globally, with a whopping $246 million of that total coming from China. With Disney due to release James Cameron’s “Avatar: Fire and Ash” in December, this newfound policy’s potential impact is coming into focus.

The box office will suffer in the short term, but what about the long term impact?

Paramount Pictures

In total, U.S. imports made around $950 million in China in the 2023 calendar year. That is but a small fraction of the country’s overall market now, but Hollywood needs every dollar it can get. “The Way of Water” still would have been a $2 billion movie even without China. But something like 2021’s “Godzilla vs. Kong” made $188.7 million of its $467.8 million global total in China. That movie was straight-up saved by those ticket sales.
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Granted, in most cases, theaters keep around half of the money from the box office, whereas studios only see about 25% of that money from China (due to international taxes and other factors). Nevertheless, 25% of $188 million is still a lot of money, while 25% of $950 million is a whole lot of money. That’s the larger point here. A lot of money studios could really use right now is going to evaporate.
The other issue, as the CFA pointed out, is that Chinese moviegoers may not be as inclined to support American movies right now, given the ongoing trade war. So, even if a movie like “Mission: Impossible — The Final Reckoning” can secure a theatrical release in China, it may be even tougher sledding than it has been of late.
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For years now, mind you, Hollywood hasn’t been able to depend on China’s box office like it used to. That’s to say, major studios couldn’t depend on robust grosses from the country even before this mess. But there’s a big difference between not being able to depend on it and wiping that money off the board entirely. That’s what we’re looking at now, and at a time when the box office is more volatile than it’s ever been, the industry at large can ill-afford such setbacks. And yet, here we are. One can only hope that this is merely a short term issue and that there aren’t long term ramifications for the relationship between Hollywood and China, though that does seem like a distinct possibility.

Sinners Review: Ryan Coogler’s Bloody Vampire Masterclass Is 2025’s Movie To Beat

“Sinners” is several things at once — a monster movie, a blood-soaked action film, a sexy and sensual thriller, and a one-location horror flick as intense and paranoia-driven as anything from the original “Assault on Precinct 13” or Quentin Tarantino’s filmography – but its greatest strength comes from how well Coogler blends every big idea on his mind. Music plays an enormously important role in the narrative, emphasized by the world-building details of how these vampires get involved in the first place. According to legend, preternaturally gifted musicians can sometimes have their music act as a mystical conduit between life and death. Throughout the film, we see how it wears its love for the artform on its sleeve. Music can be an expression of cultural traditions, of dreams for the future, of community, of outright defiance … and, on the flip side, of temptation and greed.
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It’s no coincidence that the vampires of “Sinners” aren’t only after the blood of their victims. Remmick and his ever-growing followers also have a legitimate worldview, one that’s defined by doing away with cultural divisions in favor of a “heaven on Earth” and a world ruled by pithy truisms about being kind and polite and “one people” who are “together forever” — a darkly hilarious sentiment coming from undead vampires with razor-sharp fangs and blood-red eyes. Importantly, Coogler’s script positions these villains as genuinely talented musicians in their own right, even earning a respectful nod from the trigger-happy Stack as they perform a catchy folk song in an attempt to enter the premises of their juke joint. But as Remmick menacingly growls to Sammie at one point, “I want your stories; I want your songs.” These are culture vultures in every sense of the phrase, and that added dose of real-world horror only makes them all the more terrifying.
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Everything comes to a head in a barn-burning sequence drenched in hazy lights and shadows, shot largely in a single take during Sammie’s performance and making full use of the IMAX screen and its dramatic aspect ratio changes. Almost certainly destined to end up among the best and most memorable scenes in all of 2025, this transports viewers across a dreamlike tableau of Black characters in true communion with ancestors and descendants alike — a moment of actual movie magic that needs to be seen to be believed. Director of photography Autumn Durald Arkapaw (reuniting with Coogler after “Black Panther: Wakanda Forever”), editor Michael P. Shawver, and the entire sound department deserve no end of kudos here, as does Caton’s breathtaking musical performance and composer Ludwig Göransson’s essential bluesy score. And, somehow, “Sinners” only ramps up even higher from there in a chaotic final act that I dare not spoil.
If the ending drags on somewhat indulgently (including both a mid- and post-credits scene, amazingly), well, Coogler more than earns the right. This is a one-of-a-kind experience that simply doesn’t come around very often. Hyperbole or not, I’m willing to bet we’ll be talking about “Sinners” for a long time to come.
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/Film Rating: 9 out of 10
“Sinners” opens in theaters on April 18, 2025.

5 things to do: SA Book Festival returns, Kevin Hart brings the laughs and more spring festivities this weekend

The end of Final Four in San Antonio means Fiesta and Easter-themed festivities are getting closer. Here’s the events to look out for this weekend.

SAN ANTONIO — The fun doesn’t stop in April. Just as we wrap up the Final Four in San Antonio, Fiesta and Easter are creeping up around the corner. And while the upcoming weekend will certainly be much calmer than last, there’s still plenty of free festivities lined up that you won’t want to miss.

Here’s what’s happening.

SA Book Festival

Book-lovers can look forward to the return of the San Antonio Book Festival on Saturday.

This free day-long event unites readers and writers alike. Hear from authors, purchase new reads, get your books signed, engage in lively conversations with fellow bookworms and participate in activities for the whole family. 

Explore the festival grounds and choose from food trucks offering a variety of eats.

When:  Saturday, April 12 from 9 a.m. – 5 p.m.

Where: Central Library (600 Soledad Street) and UTSA Southwest Campus (300 Augusta Street)

Cost: Free

Kevin Hart

Hollywood’s box office powerhouse and comedian Kevin Hart brings his “Acting My Age Tour” to the Frost Bank Center this Saturday.

The Emmy and Grammy-nominated entertainer, touring nationally with his 9th standup special, will bring the laughs to the Alamo City. 

Tickets are going fast so get them before their gone!

When: Saturday, April 12 at 7:30 p.m.

Where: Frost Bank Center (1 Frost Bank Center Drive)

Cost: Tickets on sale now on Ticketmaster.

Jazz in the Garden

Enjoy the soothing sounds of jazz surrounded by the peaceful atmosphere of nature Friday evening at the Japanese Tea Garden.

The Noah Peterson Quartet performs, setting the mood for a relaxing night in the garden.

Guests are invited to bring a chair or blanket for seating.

When: Friday, April 11 from 6:30 p.m. – 9 p.m.

Where: Japanese Tea Garden (3853 N St. Mary’s Street)

Cost: Free

Paw-Changa

Adopt, shop and get an early start to Fiesta and find your new four-legged friend. San Antonio Animal Care Services’ Paw-Changa 2025 will be bigger and better than ever.

With over 200+ adoptable pets, live music, 40+ artisan vendors and a foster pet parade – this free family friendly event is sure to be a “paw-some” time.

Indulge in your favorite Fiesta favorites like chicken-on-a-stick, aguas frescas and more. You can also get a chance to score the official 2025 San Antonio Animal Care Fiesta medal.

When: Saturday, April 12 from 10 a.m. – 6 p.m.

Where: City of San Antonio Animal Care Services (4710 TX-151)

Cost: Free

Easter Eggstravaganza

Bring the family out to Traders Village this Saturday for its 19th Annual Easter Eggstravaganza.

There will be thousands of free Easter eggs filled with goodies, door prizes for kids of all ages, photo ops with the Easter bunny, character appearances and more.

When: Saturday, April 12  at 10 a.m.

Where: Traders Village (9333 SW Loop 410)

Cost: Free

Plus…

This Friday, celebrate Mother Nature with Gardopia Gardens and enjoy live entertainment, free food samples, vendors and giveaways for its Earth Month Farmers Market.

On Saturday, SA Local Market hosts Second Saturday at Main Plaza. Attendees can shop from local vendors, enjoy live music and treat themselves to delicious eats and refreshing drinks.

Finally, catch a movie under the stars at the Base of the Tower of the Americas on Saturday. Grab a blanket and enjoy an outdoor screening of “Miss Congeniality as the sun sets over downtown San Antonio.

Who is Arthur Petrov? Man Accused of Stealing US Tech Returned to Russia

Arthur Petrov, a dual German-Russian citizen accused of stealing U.S. tech, was released to Russia as part of a prisoner swap between Moscow and Washington conducted in Abu Dhabi early Thursday.Petrov was detained in 2023 in Cyprus at the request of the U.S. for allegedly procuring large quantities of sensitive microelectronics for a Russian company that supplies the Russian military, the Department of Justice (DOJ) said.В обмен на Ксению Карелину США передали РФ гражданина России и Германии Артура Петрова — WSJ33-летний Артур Петров был задержан на Кипре и экстрадирован в США в 2023 году. Его обвиняли в контрабанде микроэлектроники военного назначения от американских дистрибьюторов для… pic.twitter.com/TZHTgGvM5M— SOTA (@Sota_Vision) April 10, 2025
He was swapped for Ksenia Karelina, a dual U.S.-Russian citizen who had been sentenced to 12 years in a Russian penal colony on charges of treason after donating approximately $52 to a U.S.-based charity supporting Ukraine.The prisoner exchange was arranged by CIA Director John Ratcliffe and a senior Russian intelligence official. This marks the second prisoner swap since President Donald Trump began his second term in January, signaling a slight improvement in bilateral relations during ongoing negotiations aimed at ending the war in Ukraine.Russia’s Federal Security Service (FSB) confirmed Petrov’s return to Russia in a statement released on Thursday.”With the mediation of the UAE, Russian citizen Arthur Petrov was returned to his homeland. The Russian was detained at the request of American law enforcement agencies in 2023 in the Republic of Cyprus and in 2024 extradited to the United States, where Petrov was accused of violating the export control law. In the United States, he faced up to 20 years in prison,” the intelligence service said.According to the DOJ, Petrov worked for LLC Electrocom VPK, a supplier based in Russia providing electronic components to manufacturers supporting Russia’s military efforts. He allegedly worked with two Russian nationals to operate an illicit procurement network in Russia and elsewhere overseas.The technology that Petrov and his coconspirators allegedly stole had “significant military applications” and included “various types of electronics components of the sort that have been recovered in Russian military hardware on the battlefield in Ukraine, such as Russian guided missiles, drones and electronic warfare and communications devices,” the DOJ said.He was accused of procuring more than $225,000 worth of controlled electronics components with military applications from U.S. distributors and shipping them to Russia.The Wall Street Journal reported Thursday that Moscow and Washington are discussing the fate of several other Americans or dual U.S.-Russian citizens imprisoned in Russia.”Today, President Trump brought home another wrongfully detained American from Russia,” Ratcliffe told the newspaper. “I’m proud of the CIA officers who worked tirelessly to support this effort, and we appreciate the Government of U.A.E. for enabling the exchange.”In recent years, Moscow has exchanged crypto kingpin Alexander Vinnik for American teacher Marc Fogel; arms dealer Viktor Bout for American basketball player Brittney Griner; and convicted Russian assassin and intelligence agent Vadim Krasikov for Wall Street Journal reporter Evan Gershkovich, Marine veteran Paul Whelan and Russian-American journalist Alsu Kurmasheva.

Russian President Vladimir Putin (L) looks at U.S. President Donald Trump during the welcoming ceremony prior to the G20 Summit’s Plenary Meeting on November 30, 2018 in Buenos Aires, Argentina.
Russian President Vladimir Putin (L) looks at U.S. President Donald Trump during the welcoming ceremony prior to the G20 Summit’s Plenary Meeting on November 30, 2018 in Buenos Aires, Argentina.
Mikhail Svetlov/Getty Images

China Raises Costs for US Tourists After Trump Tariffs: ‘104%

Footage has surfaced of businesses in China advertising a steep surcharge for American customers in response to President Donald Trump’s dramatic tariff hike on Chinese imports.Newsweek reached out to the Chinese Foreign Ministry by email with a request for comment outside of office hours.Why It MattersTrump, who launched a trade war with Beijing during his first term, escalated tensions again this month—imposing an 84-percent blanket tariff on Chinese goods. That came on top of a 20-percent hike enacted in March, which he said was due to China’s role in supplying chemicals used to make fentanyl.The tariffs took effect April 9 after Beijing refused to withdraw a 34-percent retaliatory duty. Trump then raised the duty again to 125 percent, accusing China of a “lack of respect” for global trade norms. He also announced a temporary 90-day pause on reciprocal duties, although the baseline 10-percent rate for most other countries stays in effect.

People walk on a street in a shopping district on April 3, 2025, in Shenzhen, China.
People walk on a street in a shopping district on April 3, 2025, in Shenzhen, China.
Getty Images
What To KnowVideos uploaded to Chinese social media show businesses advertising a service charge for American customers—at the same rate as Trump’s earlier tariff before it was raised again.A post, shared on social media platform Weibo, showed a jewelry store in Taiyuan, Shanxi Province, announcing the surcharge.Another image circulated from a hotel in Wuhan, Hubei Province.A pool hall in an unidentified city displayed a similar notice, accompanied by the English translation: “Starting from today, our store will charge a 104-percent service fee to American customers. If you have any questions, please consult the U.S. Embassy.”Many of the reactions online were skeptical of the effects. “Is there even any American consumption?” one Weibo user asked. “Not many Americans were coming to China to buy things in the first place.” Another accused the owner of leaning into nationalism for profit.What People Are SayingLin Jian, a spokesperson for the Chinese Foreign Ministry, told reporters Thursday: “Tariff and trade wars have no winner. China does not want to fight these wars, but is not scared of them.”We will not sit idly by when the Chinese people’s legitimate rights and interests are denied…If the U.S. is determined to fight a tariff and trade war, China’s response will continue to the end.”What’s Next?Neither Washington nor Beijing appears likely to back down anytime soon, keeping tensions high across a range of issues—from the technology race to China’s pressure on Taiwan and its actions in the South China Sea.

China Raises Costs for US Tourists After Trump Tariffs: ‘104%

Footage has surfaced of businesses in China advertising a steep surcharge for American customers in response to President Donald Trump’s dramatic tariff hike on Chinese imports.Newsweek reached out to the Chinese Foreign Ministry by email with a request for comment outside of office hours.Why It MattersTrump, who launched a trade war with Beijing during his first term, escalated tensions again this month—imposing an 84-percent blanket tariff on Chinese goods. That came on top of a 20-percent hike enacted in March, which he said was due to China’s role in supplying chemicals used to make fentanyl.The tariffs took effect April 9 after Beijing refused to withdraw a 34-percent retaliatory duty. Trump then raised the duty again to 125 percent, accusing China of a “lack of respect” for global trade norms. He also announced a temporary 90-day pause on reciprocal duties, although the baseline 10-percent rate for most other countries stays in effect.

People walk on a street in a shopping district on April 3, 2025, in Shenzhen, China.
People walk on a street in a shopping district on April 3, 2025, in Shenzhen, China.
Getty Images
What To KnowVideos uploaded to Chinese social media show businesses advertising a service charge for American customers—at the same rate as Trump’s earlier tariff before it was raised again.A post, shared on social media platform Weibo, showed a jewelry store in Taiyuan, Shanxi Province, announcing the surcharge.Another image circulated from a hotel in Wuhan, Hubei Province.A pool hall in an unidentified city displayed a similar notice, accompanied by the English translation: “Starting from today, our store will charge a 104-percent service fee to American customers. If you have any questions, please consult the U.S. Embassy.”Many of the reactions online were skeptical of the effects. “Is there even any American consumption?” one Weibo user asked. “Not many Americans were coming to China to buy things in the first place.” Another accused the owner of leaning into nationalism for profit.What People Are SayingLin Jian, a spokesperson for the Chinese Foreign Ministry, told reporters Thursday: “Tariff and trade wars have no winner. China does not want to fight these wars, but is not scared of them.”We will not sit idly by when the Chinese people’s legitimate rights and interests are denied…If the U.S. is determined to fight a tariff and trade war, China’s response will continue to the end.”What’s Next?Neither Washington nor Beijing appears likely to back down anytime soon, keeping tensions high across a range of issues—from the technology race to China’s pressure on Taiwan and its actions in the South China Sea.

A mouse watched YouTube. Then scientists mapped its brain.

Scientists say the map of a speck of a mouse’s brain could be as transformative as the Human Genome Project. Here’s what to know.Show Caption

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Dire wolves extinct for 13,000 years recreated from ancient DNAColossal, a Texas-based biotech company, revealed that it successfully recreated extinct dire wolves.Scientists created the largest functional map of a brain to date using a piece of a mouse’s brain.The map details the wiring that connects neurons, offering insight into brain function and organization.Researchers believe this work could eventually lead to treatments for brain disorders like Alzheimer’s, Parkinson’s and schizophrenia.Scientists have achieved a feat once believed impossible, constructing the largest functional map of a brain to date, which they believe could eventually lead to the discovery of medications for hard-to-treat brain disorders like Alzheimer’s and Parkinson’s disease.  Using a piece of a mouse’s brain no larger than a grain of sand, scientists from across three institutions created a detailed diagram of the wiring that connects neurons as they send messages through the brain.  The project, called Machine Intelligence from Cortical Networks (MICrONS), offers unprecedented insight into the brain’s function and organization that could help unlock the secrets of intelligence.  David Markowitz, a scientist who helped coordinate the project, said the data, published April 9 in the journal Nature marks “a watershed moment for neuroscience, comparable to the Human Genome Project in their transformative potential.” If you give a mouse YouTube In the study, scientists looked at a small piece of the mouse’s brain called the neocortex, which receives and processes visual information. It’s the newest part of the brain in terms of evolution, and differentiates the brains of mammals from other animals, according to researchers.  A team of researchers at Baylor College of Medicine in Houston started by recording brain activity in a portion of the mouse’s visual cortex roughly the size of a grain of salt while it watched a series of YouTube clips and movies.  Scientists at the Allen Institute, a research center in Seattle, then sliced that piece of the mouse’s brain into more than 25,000 layers, each a tiny fraction of the width of a human hair, and took high resolution photos of the slices through microscopes. The material was sent to a team at Princeton University, in New Jersey, which used artificial intelligence to reconstruct the pieces in 3D. Other scientists compared their approach to understanding a car’s combustion engine.  “Just as an engine is composed of pistons, cylinders and a fuel system, the brain consists of neurons and synapses – the tiny, specialized connections at which neurons communicate,” two Harvard researchers wrote in a companion piece to the Nature article.  The data set from the research contains 84,000 neurons, 500 million synapses and neuronal wiring that could extend the length of New York’s Central Park nearly one and a half times, molecular biologists Mariela Petkova and Gregor Schuhknecht wrote.Findings from the studies have led to discoveries of new cell types, characteristics and ways to classify cells, researchers said. The achievement also puts scientists closer to their larger goal of mapping the wiring of the entire brain of a mouse. “Inside that tiny speck is an entire architecture like an exquisite forest,” Clay Reid, a senior investigator who helped pioneer this area of study, said in a statement. “It has all sorts of rules of connections that we knew from various parts of neuroscience, and within the reconstruction itself, we can test the old theories and hope to find new things that no one has ever seen before.” Why it matters  Researchers view wiring diagrams as a foundational step that scientists can build on and, eventually, potentially use to find treatments for brain conditions like Alzheimer’s, Parkinson’s and schizophrenia.  They compare the studies to the Human Genome Project, which created the first complete map of the DNA in every human cell. The Human Genome Project has led to profound advances in drug discovery, treatments and disease screenings and helped pave the way for revolutionary gene therapies to treat certain diseases, including some cancers.With a functional map of the brain, researchers say they now have the ability to understand the brain’s form and function and have opened up new pathways to study intelligence.  Nuno da Costa, an associate investigator at the Allen Institute, described the data they collected as a “kind of Google map” of the piece of the visual cortex.  “If you have a broken radio and you have the circuit diagram, you’ll be in a better position to fix it,” he said in a statement. “In the future, we can use this to compare the brain wiring in a healthy mouse to the brain wiring in a model of disease.”