Scientists Discover Key Protein That Could Reverse Vascular Aging

Nup93 is crucial for endothelial cell health and vascular aging prevention. Research shows restoring Nup93 reverses damage and offers potential therapies for cardiovascular diseases.
Over the past several decades, research has demonstrated that endothelial cells (ECs) serve as a dynamic interface essential for vascular protection.
A recent study published in the journal Aging by Julia Michalkiewicz, Tung D. Nguyen, and Monica Y. Lee from the University of Illinois at Chicago College of Medicine underscores the essential role of the protein Nucleoporin93 (Nup93) in preserving blood vessel health during aging. The authors discuss emerging research that identifies Nup93 as a potential therapeutic target for preventing or mitigating aging-related conditions such as heart disease and stroke.
Cardiovascular diseases remain the leading causes of death worldwide, with aging identified as a major risk factor. Vascular health declines as endothelial cells (EC)—the protective lining of blood vessels—lose their functionality with age. This deterioration leads to inflammation, arterial stiffening, and reduced blood flow, significantly increasing the risk of life-threatening diseases. The authors underscore the urgent need to uncover the molecular mechanisms driving these changes.
Nup93: A Crucial Protector of Endothelial Cells
Nup93 plays an essential role within nuclear pore complexes (NPCs)—gateways that regulate molecular exchanges between the cell nucleus and cytoplasm. Age-related loss of Nup93 disrupts this delicate system, weakening endothelial cells function and accelerating vascular aging. Researchers identified Nup93 as a crucial protector of endothelial health, preventing harmful protein build-ups such as Yes-associated protein (Yap), a known driver of inflammation and cellular aging.
Excitingly, scientists have discovered that restoring Nup93 levels in damaged endothelial cells can reverse some of these harmful effects. They also found that blocking Yap can prevent issues caused by low Nup93 levels. These findings highlight the potential for new medicines or therapies to protect blood vessels as people age.
The authors propose that future treatments could involve delivering Nup93 directly to damaged blood vessels to restore their health and prevent cardiovascular diseases. They emphasize the importance of further research to uncover why Nup93 levels decrease with age and how restoring it might improve blood vessel function.
“These latest discoveries provide a fresh and innovative perspective of EC biology, highlighting NPCs as major regulators of EC health that may underlie mechanisms of vascular aging and disease progression.”
In conclusion, the editorial encourages scientists to focus on understanding how endothelial cells stay strong and the role of NPCs in keeping blood vessels healthy. This research could lead to important breakthroughs in slowing down aging and improving people’s quality of life.
Reference: “The silent protector: Nucleoporin93’s role in vascular health” by Julia Michalkiewicz, Tung D. Nguyen and Monica Y. Lee, 21 August 2024, Aging.DOI: 10.18632/aging.206097

Students’ engagement in science & tech to make Indian global leader: ISRO chief at IISF in Guwahati

Guwahati, Dec. 3: Indian Space Research Organisation (ISRO) chairman Dr S Somanath on Monday called upon the student community to grasp the innovations and advancements taking place in the fields of science and technology. Dr Somanath attended the ongoing India International Science Festival (IISF) 2024 at the Indian Institute of Technology (IIT) Guwahati campus in Guwahati on Monday. Dr Somanath participated in the ‘Student Science Interactive Programme – Face to Face with New Frontiers in S&T’ where he interacted with school students and encouraged them to explore career in science and technology and pursue innovations in the field of space research. “As students, you are the torchbearers of the future in science and technology. It is essential for you to grasp the remarkable innovations and advancements taking place in these fields today. By recognizing their potential and the opportunities they present, you can draw inspiration to pursue similar paths and contribute to building a brighter tomorrow. Reflecting on our current scientific and technological endeavours, your enthusiastic engagement is pivotal in realizing the vision of making India a global leader,” the ISRO chairman said. IISF 2024 has witnessed industry-academia collaboration, knowledge sharing technical sessions, and initiatives to inspire students and teachers on creative and knowledge-based learning. The event has brought policymakers and scientific leaders together under one roof to discuss sustainable practices across science, agriculture, manufacturing, and healthcare. A key highlight of IISF 2024 was the lab to life initiative, where CSIR signed three technology transfer Memorandums of Understanding (MoUs) on Sunday, the second day of the event, to promote sustainability and technological advancements. “Specifically focused on sustainable management, these MoUs underscore CSIR’s commitment to leveraging science and technology for environmental preservation, enhancing industry competitiveness, and driving socio-economic development through innovative and practical solutions. CSIR-NIIST’s biodegradable cutlery technology was transferred to Devaki Engineering Enterprises, Bengaluru, featuring a Rotary Bio-Degradable Manufacturing Machine (MU-SUROTO) that enhances agricultural sustainability,” said a press release. In addition, CSIR-Central Road Research Institute (CRRI) and Rajasthan Technical University entered into a partnership to advance road infrastructure R&D. CSIR-Institute of Himalayan Bioresource Technology’s (IHBT) Lilium Bulb Processing technology was transferred to Shansha Cut Flower Cluster, Lahaul and Spiti, to boost the floriculture sector. Speaking about the technology transfer, Dr C Anandharamakrishnan, Director of CSIR- NIIST, Thiruvananthapuram, said that students are the torchbearers of the future in science and technology. “Young innovators like you (students) have already begun building rockets and satellites in colleges, efforts that are nearing commercial success. Today, India is actively developing and launching satellites, showcasing the immense potential of this field. By understanding these advancements and the opportunities in the field of space, science, and technology, you can be inspired to pursue similar paths and shape a brighter future. Your active engagement is essential to making India a global leader in science and technology,” Dr. Anandharamakrishnan said.

SIXGEN Acquires Kyrus Tech

Cybersecurity company SIXGEN has acquired software development firm Kyrus Tech to expand its capability to deliver advanced platforms and services designed to meet the complex needs of national security customers across multiple aspects of the digital domain.
SIXGEN said Monday it will add to its talent pool approximately 80 engineers and subject matter experts from Kyrus.
Kyrus CEO Dan Hall will join SIXGEN as a board director and as an executive vice president.
“Kyrus brings highly specialized capabilities that align with SIXGEN’s vision of building a formidable ecosystem of solutions for the modern digital warrior,” said SIXGEN CEO Jack Wilmer.
Delivering Cyber Platforms to Federal Clients
Kyrus provides mission-critical cyber platforms for defense, intelligence and federal agencies.
The Sterling, Virginia-based company specializes in reverse engineering, software and hardware development and data science to help customers advance national defense and ensure critical infrastructure security.
Boldend & Secure EE Acquisitions
The latest transaction marks the third acquisition for SIXGEN, which was acquired by private investment firm Washington Harbour Partners in November 2023.
In July, SIXGEN purchased cybersecurity firm Secure Enterprise Engineering as part of a push to broaden its software offerings, client relationships and technical talent. 
The following month, the Washington Harbour portfolio company moved to buy Boldend to integrate into its portfolio the latter’s cyber automation tools, software and electronic warfare platforms and add engineering and technical talent to accelerate the development and delivery of capabilities to digital warfighters and support U.S. defense and national security missions. 
“Grounded in the thoughtful integration of the expertise of Kyrus, Boldend, and Secure EE, SIXGEN is ushering in a new era of technology in key areas, unifying Full-spectrum Cyber, Electronic Warfare, Secure Radio Frequency Communications, and other multi-domain digital operations. This consolidated strength enables us to double down in our support of the nation’s most critical, mission-oriented agencies and accelerate our priorities,” Wilmer stated.
According to SIXGEN, the latest acquisition reflects Washington Harbour’s efforts to advance strategic investments in full-spectrum cyber as part of its commitment to advancing national defense and critical infrastructure security.
Holland & Knight and PwC served as Washington Harbour’s legal counsel and financial adviser, respectively, in the transaction. Morse Law advised Kyrus Tech on the deal’s legal aspects.

[embedded content]

Hickory novelist Marissa Eller: Representation in books is important

Billy Chapman

Young adult novelist and Hickory native Marissa Eller said she thinks it is important to highlight the stories of people frequently underrepresented in books.“Everyone deserves to see themselves in books in any kind of way,” Eller said.Eller said the young adult books she read as a young woman often featured characters with illnesses. What was missing was a happy ending. She said it was common for one of the characters to die.“I wanted to write about that (chronic illness) from my own experience where it can be joyful and happy and no one dies,” Eller said.Eller’s first book, “Joined at the Joints,” is a young adult romance novel about two teens, Ivy and Grant, who meet at a chronic illness support group.Ivy, who struggles with social anxiety, does not expect to enjoy the group. However, she meets charming Grant, who understands her.

People are also reading…

“She doesn’t tell anyone about her chronic pain, so she’s just keeping this super heavy secret, and no one’s able to connect with her because she won’t let them,” Eller said.

Marissa Eller stands with her books at the Bookmarks Festival in Winston-Salem.

Courtesy of Marissa Eller

The story follows their relationship, and Ivy’s struggles with juvenile rheumatoid arthritis.The book was released in July. On goodreads.com, “Joined at the Joints” has a score of 4.18 out of 5 from 233 ratings. Out of 61 reviews, about 95% are positive.Eller was diagnosed with rheumatoid arthritis at the age of 21. Now 27, Eller said she has found ways to deal with the pain by finding the right treatments and adjusting her lifestyle.Eller’s second book is set for release in early 2026. It will be a young adult book set in Hickory and based on Eller’s experiences at Challenger High School.When not writing, Eller works as a consultant for students trying to get into medical schools.This interview was edited for clarity and length.How do you create stories?It always starts somewhere from my own experience. There’s aspects of me in each character. I always start with a character first, learn who they are and figure out their stories from there.I don’t write these super-high concept fantasies that you explain to people what the world is. I just write super quiet stories, and I explain who the character is. And usually it’s some part of me, more than one, but using some aspect of myself is where I start from.How did you get into writing?I went to Challenger High and as part of that you take college classes. In one of my writing classes we were challenged to write for National Novel Writing month, which is in November. The concept of National Novel Writing month is to write 50,000 words in a month. I wrote maybe 10,000 words. At 16, I was not going to do a whole novel.I tried. I can’t remember what that first book was, but that was the first time I tried writing fiction. I remember the feeling of peace from it and that’s why I still write. It’s my therapy.Now, I can write about 2,000 words a day when I’m drafting something.

Eller’s first novel, “Joined at the Joints,” can be found online through Amazon, Barnes & Noble, bookshop.org and other retailers.

Courtesy photos of Marissa Eller

What was life like growing up?Pretty normal, pretty typical. I was just pretty nerdy. I’ve always been pretty nerdy. As a kid, I read like crazy. I went to Clyde Campbell Elementary and Arndt Middle before Challenger. It was me, my parents and my little brother. We moved in with my grandparents to take care of them when I was about 15. My parents still live with my grandmother.I used to volunteer at Trinity Village on Springs Road. My mother (Catawba County Chamber of Commerce Events Coordinator Melissa Eller) worked there for 17 years. Every summer, I would volunteer there. My sister did, too. That was fundamental for me, kind of growing up there. She did activities there, and I was all over the building, meeting all kinds of people. She worked on the memory care unit for a long time, so from a young age I’ve been able to understand what that means. When we moved in with my grandparents, it wasn’t difficult to shift to a caregiver role, having been around adults in a caregiver capacity for so long.What are your hobbies?I love to bake. My sister and brother-in-law are involved in community theater a lot, so I love to go and see what they’re working on.I also collect Betsey Johnson stuff — clothes and décor. Decorating my house is a hobby. She’s pretty out there with bright patterns and colors and prints. Even though, nine times out of 10, I’m wearing all black, if you go in my house its an explosion of color.What motivates you?Helping people. That’s why I wanted to publish my book. I wrote at first for myself but I wanted to publish it because there are so many teens not seeing themselves in books in a positive way. We’ve come a long way, though. I have so many friends that are publishing similar books.I’ve gotten a bunch of messages from readers all over the world telling me how much the book meant to them. That’s been wild. Getting those messages is a big accomplishment. To know I can somehow help someone even though I don’t know them and they don’t know me, it means a lot that my work has touched them somehow.Education is extremely important to me. I’m a first-generation college student, and I enjoy helping people get into medical school, especially people who are underrepresented. And getting books in the hands of kids is a mission.When are you happiest?Either when I’m with my family or when I’m writing. I just love my family so much. I dedicated the books to them. I dedicated this first book to my mom, dad and brother. I dedicated the next book to my sister and my best friend. Those are just my people.Writing is my peace. It’s always on the back burner in my brain. When I sit down at the computer, it comes to the forefront. It’s the only time I’m focused on doing one thing at a time.What’s the biggest challenge you’ve had to overcome?In life and in writing, there’s a lot of ableism. The publishing process has been difficult. A lot of agents and editors questioned whether there was room in the market for this quiet story about chronic illness and people being happy. It took a really long time to get the book published. I felt like it was a me problem at first, but in speaking with other disabled authors who write similar books I learned you have to keep trying to find the right people to get your book out there.
Billy Chapman is a reporter with the Hickory Daily Record.

Watch as leering Putin gets into bizarre row with female scientist about SPERM after she lands subtle dig at his regime

THIS is the moment Putin had a bizarre argument with a female Russian scientist about sperm’s swimming ability.The dictator, 72, defended spunking Russia’s budget on his crackpot war in Ukraine after the scientist made a dig at his reckless spending.Vladimir Putin got into a bizarre row with a scientist about spermCredit: East2West News Professor Maria Vedunova, 43, was feeling brave when she challenged the dictator about spermCredit: East2West News Putin has been obsessed with making Russians have more babies in recent monthsCredit: AFPThe father-of-five, faced off with Professor Maria Vedunova, Director of Biology at Lobachevsky University, over whether sperm can “swim where they need to”.The ballsy biologist told Putin: “Vladimir Vladimirovich [Putin], if I may, there is a problem here,” at a meeting with Russia’s top young scientists.“There is a misconception that everyone believes that sperm know where to swim.”This is not true.”READ MORE ON PUTIN’S PLANSClearly taken aback, Putin said: “I’m sorry, I didn’t hear you. Tell me again.”Not backing down, Vedunova, 43, a prominent nerve specialist, said: “Sperm know where to swim.“Everyone thinks so.“It’s not true, they don’t know.Most read in The Sun“And even of those that swim in the right direction, not the first one fertilises, somewhere around a hundredth.”Putin fired back: “Whether they know or not, they swim where they need to go.“This is the most important thing.”Ministry of SEX being considered in Russia to boost plummeting birth ratesBut she corrected him: “These are only the ones we will learn about.”She used the example of sperm not where they are swimming to his regime for failing science.She told him: “It’s the same in science.“Exploratory research – we don’t know where to swim.“And a lot of people swim in the other direction.”Vlad looked embarrassed as others in the room chuckled at her clever dig at his regime.Putin has drained funding from science research in Russia to pour into his ridiculous war with Ukraine, which has seen hundreds of thousands of Russians killed and maimed.Going on the defensive, he said: “I understand [certain] issues are definitely linked to financing.“We have a goal set and we will implement it.“Two per cent of the GDP should go to science by 2030.”He also said that Russia must educate one million engineers in the next three years, with 1.8 million by 2030.In Russia’s new budget, an eyewatering 39 per cent is funneled into defence, his security services and law enforcement.Science will get less than one per cent.Putin made it clear he disagreed with the scientistCredit: East2West News Onlookers were clearly amused by the bizarre spatCredit: East2West News This is not the only time vulgar Vlad has been obsessed by sperm and birthrates.Putin has given a lot of thought to baby making lately as he struggles to maintain a steady population to supply his meat-grinder front line.In September the Kremlin announced a sex-at-work policy to make Russians have more babies.The plan will apparently solve the problem of citizens complaining they don’t have enough time or energy for late-night romps.It will see staff allowed to get it on during their lunch and coffee breaks in peace.Bosses have even been told to encourage all midday rendezvous.Vlad is even dreaming up a “Ministry of Sex” in a desperate attempt to remedy the country’s plummeting libido and birth rates.A number of insane plans are being proposed for the new department.One unbelievable proposal is to turn off the Internet – and even the lights – between 10pm and 2am to encourage couples to have sex.Another bizarre idea is for the state to pay stay-at-home women raising children for doing housework – and include this in their pension calculations.READ MORE SUN STORIESThe Ministry of Sex also has a notion that the state should pay for first dates – up to the value of a whopping £40.Vlad seems not to have twigged that the main issue is sending droves of soldiers to fight on the front line – resulting in the deaths of over 100,000 Russian soldiers.Putin clings onto a child as he thinks about how to up Russia’s birth rateThe Ministry of Sex is one of Vlad’s stranger ideas

China bans exports of key high-tech materials, hitting back at US chip sanctions

BANGKOK — China announced Tuesday it is banning exports to the United States of gallium, germanium, antimony and other key high-tech materials with potential military applications. The Chinese Commerce Ministry announced the move after the Washington expanded its list of Chinese companies subject to export controls on computer chip-making equipment, software and high-bandwidth memory chips. Such chips are needed for advanced applications. The ratcheting up of trade restrictions comes at a time when President-elect Donald Trump has been threatening to sharply raise tariffs on imports from China and other countries, potentially adding to simmering tensions over trade and technology. China said in July 2023 it would require exporters to apply for licenses to send to the U.S. the strategically important materials such as gallium and germanium. In August, the Chinese Commerce Ministry said it would restrict exports of antimony, which is used in a wide range of products from batteries to weapons.China is the biggest global source of gallium and germanium, which are produced in small amounts but are needed to make computer chips for mobile phones, cars and other products, as well as solar panels and military technology.China’s Commerce Ministry protested and said it would act to protect China’s “rights and interests” after the U.S. side announced it was adding 140 companies to a so-called “entity list” subject to strict export controls. Nearly all are based in China, though some are Chinese-owned businesses in Japan, South Korea and Singapore. Both governments said their respective export controls were needed for “national security.” In hitting back at the latest move by Washington to slow China’s progress in developing advanced technology with potential military applications, China is tightening controls announced in July 2023. China’s government has been frustrated by U.S. curbs on access to advanced processor chips and other technology on security grounds but was cautious in retaliating, possibly to avoid disrupting China’s fledgling developers of chips, artificial intelligence and other technology.The U.S. gets about half its supply of both gallium and germanium metals directly from China, according to the U.S. Geological Survey. China exported about 23 metric tons (25 tons) of gallium last year and produces about 600 metric tons (660 tons) of germanium per year.

MK Lit Fest hosts the city’s first free Indie Book Fair – meet your new favourite authors!

Watch more of our videos on ShotsTV.com and on Freeview 262 or Freely 565Visit Shots! nowNew books galore from the wealth of writers in and around Milton Keynes who have made their work available with small, indie presses or by self-publishing.With free entry, MK Lit Fest is thrilled to hold Milton Keynes’ first Indie Book Fair on 7 December in MK Central Library, and to have the opportunity to present over 30 writers to you – their newest readers. Go to www.mklitfest.org for more!You’ll be spoilt for choice across a whole spectrum of genres: our authors have published volumes of crime, mystery, fantasy, Young Adult, children’s books, poetry, self-help, memoir, sci-fi, humour, essays, travel and more. There truly is something for everyone!And what’s more, you’ll have the chance to talk to them all in person, hear them read from their work – there will be readings by the writers through the day – and, of course, to buy loads of wonderful Christmas presents for yourself and all of your book-loving friends. MK Indie Book FairIndie Book Fair takes place on Saturday 7 December in MK Central Library, 555 Silbury Boulevard, CMK. The doors will open at 11am, and the fair will continue till 4pm. Best of all, entry is absolutely free!And that’s not all…Mk Lit Fest – a fabulous festival of books, writers, words and ideas – organises events and opportunities for writers and readers throughout the year. Their final event of 2024 takes place online on 18 December, as the winning writers of submitted season flash fiction read their stories in Lit Fest’s year-closing Never Mind the Baubles event.Local writers also have until 19 January to submit their writing for the MinK2025 Creative Writing Competition on the theme of ‘Home’, with prizes for winning entries and publication in the fifth volume of the Festival’s wonderful #MinK anthologies. This will be launched at the Spring Festival, taking place between 9 and 12 April: full details will be announced shortly.For more info – including upcoming in-person and online events in the opening months of 2025 – visit the Festival website at www.mklitfest.org (where you can sign up for their newsletter) or follow @MKLitFest on Facebook, X, Instagram, BlueSky or Threads.Continue Reading

Technology provider on track for £7m-turnover

A technology provider which has a major office in Romsey is on track to more than double its turnover from £2.5m to £7m, three years on since the company’s inception. Workspace Audio Visual specialises in digital office transformation technologies and provides video conferencing tools, digital signage and office/employee management systems,which are designed to facilitate creativity…