U.S. House of Representatives Minority Leader Hakeem Jeffries, D-N.Y., repeated the unsubstantiated argument that the Defending Women and Girls in Sports Act would have “unleashed” sexual predators on girls in the U.S. Jeffries first made this argument the day the House voted on the bill Jan. 14, joining other prominent Democratic representatives, including Alexandria Ocasio-Cortez,…
Cancer affects millions of individuals and their loved ones each year. Both hematologic or blood cancers, and solid tumors can have fatal outcomes. Fortunately, the advancement of medicine and technology has helped generate robust and effective therapies against many different types of cancers. While many primary sites of cancer have been well controlled through cancer therapies, cancer recurrence is still a pressing issue for physicians to treat. Additionally, when cancers recur, the disease is in a different tissue. The growth of tumor in areas of the body different from the primary cancer location is known as metastasis.
Metastatic burden is a major obstacle to effective and curative treatment. Unfortunately, once tumors have progressed to a later stage, metastasis is almost always present. In many cases, metastasis is the driving factor that predicts therapeutic outcome and patient survival. Currently, physicians and scientists are working to understand how metastases develop and better improve patient care.
Many scientists have worked to understand how to prevent cancer. One of the obvious ways to reduce cancer risk is by living a healthy, well-balanced lifes. However, in the last decade aspirin was found to help reduce risk for cancer. While low doses of daily aspirin can have deleterious side effects, scientists are still working on understanding the role aspirin has in cancer prevention and control.
A recent article in Nature, by Dr. Rahul Roychoudhuri and others, demonstrated that aspirin can prevent metastasis in cancer. Roychoudhuri is Professor of Cancer Immunology and Immunotherapy at the University of Cambridge, Department of Pathology. He is also the Director of the CRUK Cambridge Center Training Program and Director of Studies in Pathology at St. Catherine’s College. His work focuses on the immune response to cancer and how to better develop therapies. More specifically, Roychoudhuri works to understand the interaction of immune cells known as T cells and their ability to recognize and target cancer. He is internationally known for his work and has uncovered molecular mechanisms that are necessary for anti-tumor immune response.
Roychoudhuri and his team screened over 800 genes in mice and found only 15 were associated with cancer metastasis. Specifically, they discovered that mice lacking a gene, that has the information to create a protein known as ARHGEF1, had less metastatic burden. After further investigation, researchers found that ARHGEF1 protein suppresses T cells that normally recognize and target metastatic cancer cells. Scientists revealed that ARHGEF1 is switched on in T cells after being exposed to a clotting factor known as thromboxane A2 (TXA2). Interestingly, TXA2 is produced by platelets and helps in the process of wound-healing. Aspirin works to reduce TXA2 and thin the blood. Therefore, aspirin reduces TXA2 in T cells and enhances their ability to function and target cancer cells. Researchers found that reducing TXA2, turns ARHGEF1 “off” and allows the T cells to properly function.
This foundational work provides the mechanism by which aspirin prevents the establishment of cancer. Additionally, this discovery supports current clinical trials investigating how aspirin prevents the susceptibility to specific cancers. Overall, this work further advances our understanding of aspirin and how it can enhance therapeutic efficacy and improve patient outcomes.
Article, Nature, Rahul Roychoudhuri, University of Cambridge, CRUK Cambridge Center, St. Catherine’s College
1. Types of Business Entities –
The main business entities in Greece are the following: i) the Société Anonyme (S.A.); ii) the Private Company (P.C.); iii) the Limited Liability Company (Ltd); iv) the General Partnership and the Limited Partnership and v) the Branch. There are also several types of business entities that are used for specific purposes such as the very popular branches/offices of foreign shipping companies of art. 25 of law 27/1975 and the branches and companies of law 89/1967 (for the purposes of the present presentation, the branch and the business entities of laws 27/1975 and 89/1967 are presented only briefly).
Please see full publication below for more information.
Breadcrumb Trail LinksNewsLocal NewsIf marketing and bureaucratic hurdles can be cleared, Travel Alberta says northern lights, outdoor and Indigenous cultural experiences, and sports gives the region potential for developing a thriving tourism industry.Published Mar 06, 2025 • 4 minute readA dancer in regalia at the Athabasca Tribal Council’s cultural festival at Snye Point Park on September 16, 2023. Vincent McDermott/Fort McMurray Today/Postmedia NetworkArticle contentThis is Part 2 in the Fort McMurray Today’s contribution to Postmedia’s national series “How Canada Wins.” We’ll chronicle our community’s place in the country, the promise of greater prosperity and the blueprint to get there. See last week’s article here.Advertisement 2Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentArticle contentRecommended VideosArticle contentThe Alberta government sees “significant potential” for a tourism industry in the Fort McMurray Wood Buffalo region, according to a report from Travel Alberta. The report also found Fort McMurray Wood Buffalo ranks last for preparedness out of 10 other Alberta regions outside Edmonton and Calgary.But by 2035, Travel Alberta sees Fort McMurray Wood Buffalo as “the land of the Northern Lights, where visitors from across the globe enjoy viewing dark skies from some of the most unique accommodations in Alberta.”“Whether learning about Indigenous ways of life, flying out to a remote lodge, exploring the incredible backcountry, attending (or competing in) a world-class sports event, enjoying local flavours, or learning more about the zone’s peoples, heritage and industry, travellers to this zone are treated to a true northern experience,” reads a section of the report describing Travel Alberta’s vision for 2035.Advertisement 3Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentGetting there will be a difficult job that will require support from different levels of government and industry, says Lisa Sweet, interim CEO of Fort McMurray Wood Buffalo Economic Development and Tourism (FMWBEDT). The organization’s board chair, Terrence Cooper, says it’s a good sign that the Alberta government wants a stronger tourism industry outside of Edmonton, Calgary and the Rocky Mountains.“They’ve identified our region as being one of the prime areas for substantial growth,” Cooper said in an interview. “We want to be able to promote tourism and also continue to promote the businesses within our community to develop skills that will allow them to ramp up and grow.”The report mentions Fort McMurray has advantages for creating a tourism industry. The report and FMWBEDT’s leadership have also noted the northern lights can be a huge tourism draw. Travel Alberta also sees opportunities in outdoor activities, particularly in hunting and fishing. Wood Buffalo National Park is also a UNESCO World Heritage Site and the region has easy access to an extensive river system.Advertisement 4Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentThe Fort McMurray International Airport is new and can handle international flights, while facilities such as MacDonald Island Park are ready for large events.Encouraging local sports tourism has been named a priority by the municipality and Fort McMurray’s athletic community. In the last 10 years, the region has hosted the Arctic Winter Games, Alberta Winter Games, Western Canada Summer Games and dozens of sporting events at the youth and college levels. Fort McMurray Wood Buffalo is scheduled to host the 2026 Alberta 55-Plus Provincial Games.The region is also culturally diverse, the report notes, and can lean into Indigenous cultural experiences. There are also opportunities for historical tourism connected to the oilsands and the fur trade.Advertisement 5Story continues belowThis advertisement has not loaded yet, but your article continues below.Article content The northern lights shine above the boreal forest outside Fort McMurray on October 10, 2024. Vincent McDermott/Fort McMurray Today/Postmedia NetworkSignificant hurdles preventing tourism in Fort McMurrayBut the report also found hurdles. The biggest challenges comes from residents and Albertans, as Travel Alberta found mixed attitudes towards developing tourism from residents and little interest as a destination by Albertans.“Pride of place is very strong among residents, but, when asked if they would consider their region to be a tourism destination, most said no,” the report found.Stereotypes about the oilsands and Fort McMurray makes it difficult to promote the region. Out of 10 regions outside Edmonton and Calgary, Travel Alberta found Fort McMurray Wood Buffalo is last in familiarity and overall impression among Albertans. The region ranked second last when Albertans were asked how likely they were to visit, beating the Northeast Lakelands region that includes Cold Lake and Lac La Biche.Advertisement 6Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentOther issues raised in the report were hotels are lacking compared to what tourists expect, few places to stay in rural areas, and few businesses capable of catering to tourists. Labour shortages were found to be common. Leases and permits on Crown land can be tricky because of oilsands developments. There are also plenty of places across Canada and around the world successfully bringing in tourists to gawk at the northern lights.Not counting the commuter workforce, the visitors that do come to Fort McMurray do no stay long. The latest data from 2019 shows about 44 per cent of those people are repeat visitors, but their average stay was 55 hours. Boats in the Clearwater River near Fort McMurray, Alta. on June 20, 2013. Ryan Jackson/Postmedia Network“What is lacking is a large-scale anchor product that will draw high-value visitation to the area and help to differentiate this zone as a unique, must-see attraction for both domestic and international travellers,” the report argues.Advertisement 7Story continues belowThis advertisement has not loaded yet, but your article continues below.Article content“Additional supporting products and amenities, such as accommodations and restaurants, are required in the more remote areas of the zone where tourism development opportunities have been identified. Filling gaps in product types will be a priority as we work to develop this zone into a desirable tourist destination.”Dianna De Sousa, executive director of the Fort McMurray Chamber of Commerce, says tourism is worth pursuing but not as a primary industry for the region.“A short-term opportunity is sports term because we have the facilities for sports and athletics,” she said. “If we had the opportunity to build a tourism product that didn’t exist anywhere else in a mature form, that would be easier and quicker. I do think the opportunity for us is industry attraction… new businesses and economic diversification is where there are opportunities.”Advertisement 8Story continues belowThis advertisement has not loaded yet, but your article continues below.Article contentStill, the province has high hopes for tourism in the region. The Alberta government has a goal of generating $25 billion annually in tourism dollars by 2035, more than double tourism spending in 2022. Tourism and Sport Minister Joseph Schow said in an April 2024 interview this will require tourists going to places outside Banff, Jasper, Edmonton and Calgary.“Having been there a few times now and seeing it first-hand, I definitely understand the allure of the region and now we just want to get more people there from around the world,” he said.Get the news and events of Fort McMurray Wood Buffalo in your inbox every Friday morning by signing up for our [email protected] contentShare this article in your social networkComments Join the Conversation Featured Local Savings
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Kailey Mitchell constantly has her finger on the pulse of what is happening in Cochrane.
Mitchell recently shared her thoughts on the excitement of operating a small business in Cochrane, and using her business as a way to empower other local women and entrepreneurs in the community.
From opening the doors of The Social Spot on 222 First St. West to operating Quirk Social in the same building, Mitchell wears several hats.
“Quirk Social is the business office where we do event management,” Mitchell explained. “We plan a lot of the bug events in Cochrane like the Bow Valley Bootstomp, Cochrane Food Festival, Pet Expo, and other smaller events we bring to the community.
“Downstairs, is the Social Spot Marketplace which is a retail store full of all Alberta-based vendors and makers.”
Between her two operations, Mitchell said it has been fun and challenging to bring her passion to the community that she grew up in.
“To work with people in the community, with Alberta vendors with the store and helping support the local economy in Cochrane, as well as Alberta, all of that just makes my heart so happy,” she said. “It’s been really great to watch that grow over the last few years and all the connections we’ve made in the community, between both businesses.”
With an all-female staff, Mitchell said she is surrounded by a team who are passionate about their work.
“I think it really important to be able to give jobs to everyone who lives locally in the community,” she said.
Last year, Mitchell and her team brought the Bow Valley Bootstomp, Cochrane’s very own country music festival, to the community. Looking back, she said it was nothing short of a good time for everyone involved.
“It was a really fun event,” she said. “I think it’s an important event to continue to support Alberta-based musicians, but also something different for the community. I like the small-town feel, and it’s just an incredible experience and tons of fun.
“That’s the kind of thing that I wanted to bring to Cochrane.”
Michell said that there is a large group of female entrepreneurs in Cochrane, adding that all support one another.
“I think that’s really cool to see and it’s super important for our community and the growth of our local business,” she said. “Businesses in town support locals, the people that work here, and keep the local economy going. There’s so many people who travel to the city for work and don’t spend a lot of time in the community, and there’s a lot of awesome people to support.”
With several events planned in the future, Mitchell said residents can find out more about what’s coming to Cochrane by visiting www.quirksocial.ca.
(WXYZ) — A 32-year-old man with disabilities has been returning bottles and cans for people all across metro Detroit for more than a decade — and now, he’s on a mission to help others find success.All you have to do is make an appointment online, put out your cans and bottles, and Tyler Laviolette will be there to pick them up. It’s a business that’s become so successful for Tyler, he’s teaching others with disabilities to do the same thing.
Running his own bottle return service for more than a decade, Tyler says he loves what he does. “I’m my own boss, I basically set my own hours, it’s awesome,” said Tyler.
And his mother, Rhonda Gelstein, loves watching her son excel.”At first it was very rewarding, because people were using his service, because he was an individual with autism, it was like ‘oh we’re going to help this young guy out’ and now almost 12 years later, it’s very much a viable business,” said Rhonda.
Tyler’s returning bottles and splitting the profit 50/50 with all kinds of customers who gave him the bottles, including homeowners, large corporations, small businesses, and even a local beach association.”He picks up the bottles and then once a month they send our association a check,” said Kathi Moore, president of Randgate Beach Association in Waterford.Kathi says they’ve been using Tyler’s Bottle Service for about a year. We met Kathi at during our first “Let’s Talk” event that we kicked off in Waterford on Wednesday — and she thought Tyler should be highlighted for all of the work that he does. Related Video: 7 News Detroit holds “Let’s Talk” event in Waterford
7 News Detroit’s ‘Let’s Talk’ is in Waterford and we’d love to see you there!
“People just put them in garbage bags and bring them down and the Tyler takes them all,” said Kathi. We actually spoke with Tyler back in 2015 when his business was just starting up. “I just want other people to work, that’s more important,” said Tyler in 2015. Watch the piece from 2015:
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Now, 10 years later, he’s putting his words into action, mentoring more than 20 people with disabilities, who started their own bottle return business.”You can do it, there’s nothing really stopping you,” said Tyler.
Rhonda says, “The more people that are out helping the community that have disabilities, the more widely accepted it is.”To learn more about Tyler’s Bottle Service, click here.He says he looks forward to serving more customers and mentoring more people who want to return bottles just like him.”So what if I’m autistic? So what if I have cerebral palsy? I’m out here making a living — that’s what matters,” said Tyler. Where Your Voice MattersContact our newsroom
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By JONATHAN CHADWICK FOR MAILONLINE Published: 14:00 EST, 6 March 2025 | Updated: 14:00 EST, 6 March 2025
When Yellowjackets is airing, all I can think about is Yellowjackets, which tracks given my weekly 5,000+ word recaps of every episode. There are plenty of Yellowjackets-themed book lists out there, but none of them are specifically and categorically queer — until now! Behold: a list of books across genres that in some way evoke Yellowjackets in theme, content, structure, or…
Among the many crimes Russia is accused of committing in Ukraine, few are as shocking as the mass abduction and ideological indoctrination of Ukrainian children. Ukraine has identified around 20,000 children subjected to forced deportations since the full-scale invasion began three years ago, but officials believe the true number of victims may be far higher.…